Results 31 to 40 of about 4,774 (193)

Multimodal MRI and multiomics reveal high‐risk neurophenotype in brain‐gut circuits as therapeutic target for Crohn's disease

Interdisciplinary Medicine, EarlyView.
Through a translational framework combining prospective dual‐center clinical cohorts with dextran sulfate sodium‐induced colitis models, this work integrated advanced neuroimaging, multi‐omics and neuromodulation interventions to redefine the high‐risk neurophenotype as a sustained pathogenic driver rather than a mere phenomenon, proposing brain‐gut ...
Xuehua Li, Ruonan Zhang, Xiaodi Shen, Shaochun Lin, Chuhuai Wang, Weikai Zheng, Weimiao Kong, Zihao Lin, Rongchang Li, Caiguang Liu, Xin Cao, Li Huang, Weitao He, Jinjiang Lin, Haijie Wang, Zhoulei Li, Marietta Iacucci, Subrata Ghosh, Zhenpeng Peng, Canhui Sun, Minhu Chen, Guang Yang, Yejun Wang, Ren Mao, Shi‐Ting Feng   +24 more
wiley   +1 more source

Synthesis, characterization, and antimicrobial activities of palladium Schiff base complexes derived from aminosalicylic acids

, 2017
The final publication is available at Springer via http://dx.doi.org/10.1007/s11243-017-0130-3Six Schiff base compounds have been prepared from the condensation of o-vanillin, 2,3-dihydroxybenzaldehyde and 2,3,4-trihydroxybenzaldehyde with 4 ...
Alex J. Veinot, Gormley, Patrick T., Muyang Zhou, Vogels, Christopher M., Masuda, Jason D., Baerlocher, Felix J., Westcott, Stephen A., Jason D. Masuda, Taylor M. Brooks, Jennifer A. Klaus, Veinot, Alex J., Warman, Alexander M., Adam Palayew, Christopher M. Vogels, Felix J. Baerlocher, Zhou, Muyang, Palayew, Adam, Alexander M. Warman, Patrick T. Gormley, B. Ninh Khuong, Ninh Khuong, B., Klaus, Jennifer A., Stephen A. Westcott, Brooks, Taylor M.   +23 more
core   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, EarlyView.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source

Antitubercular potential and pH‐driven mode of action of salicylic acid derivatives

FEBS Open Bio
In the search for new antituberculosis drugs with novel mechanisms of action, we evaluated the antimycobacterial activity of a panel of eight phenolic acids against four pathogenic mycobacterial model species, including Mycobacterium tuberculosis.
Janïs Laudouze, Thomas Francis, Emma Forest, Frédérique Mies, Jean‐Michel Bolla, Céline Crauste, Stéphane Canaan, Vadim Shlyonsky, Pierre Santucci, Jean‐François Cavalier   +9 more
doaj   +1 more source

Epidemiology and Clinical Outcomes of Inflammatory Bowel Disease: A Hospital-Based Study in Central Taiwan

Gastroenterology Research and Practice, 2019
The incidence and prevalence of inflammatory bowel disease (IBD) are low but increasing in Taiwan. We aimed to investigate the epidemiology and clinical outcomes of IBD in central Taiwan.
Jen-Wei Chou, Hsiang-Chun Lai, Chia-Hsi Chang, Ken-Sheng Cheng, Chun-Lung Feng, Tsung-Wei Chen   +5 more
doaj   +1 more source

Impact of 5‐ASA discontinuation in children with ulcerative colitis on biologic therapy: A propensity score‐matched study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives 5‐Aminosalicylic acid (5‐ASA) is recommended as a first‐line medication in mild to moderate ulcerative colitis (UC), but indications regarding its use in children with moderate to severe disease treated with biologics are lacking.
Giulia D'Arcangelo, Luca Scarallo, Giulia Mancuso, Mara Corpino, Claudio Romano, Lorenzo Norsa, Serena Arrigo, Matteo Bramuzzo, Maria Teresa Fioretti, Giovanna Zuin, Maria Teresa Illiceto, Paolo Lionetti, Marina Aloi   +12 more
wiley   +1 more source

Pouchitis – What’s new in etiology and management

Canadian Journal of Gastroenterology, 1995
Pouchitis requires a clear clinicopathological definition. There are many conflicting data concerning etiology. It is linked to an initial diagnosis of ulcerative colitis by clinical association and occurrence of extra-alimentary manifestations ...
R John Nicholls
doaj   +1 more source

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

THE INHIBITION OF SULPHANILAMIDE ACETYLATION BY AROMATIC AND HETEROCYCLIC CARBOXAMIDES AND CARBOXHYDRAZIDES

, 1955
The acetylation of sulphanilamide by pigeon liver extracts was found to be markedly inhibited by amides of salicylic, 5-bromosalicylic, 5-methylsalicylic, and 6-aminonicotinic acids, and by hydrazides of benzoic, salicylic, 4-aminosalicylic, nicotinic ...
Willard J. Johnson
core   +1 more source

Ulcerative colitis: molecular insights and intervention therapy

Molecular Biomedicine
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, diarrhea, rectal bleeding, and weight loss. The pathogenesis and treatment of UC remain key areas of research interest.
Yuqing Liang, Yang Li, Chehao Lee, Ziwei Yu, Chongli Chen, Chao Liang   +5 more
doaj   +1 more source