Results 91 to 100 of about 89,264 (312)
Ecotoxicology and Environmental Safety, 2022 Glyphosate and its metabolite aminomethylphosphonic acid (AMPA) draw great concern due to their potential threat to aquatic ecosystems. The individual and combined effects of glyphosate and AMPA on aquatic plants in different ecological niches need to be
Mengjie Qu +5 more
doaj
Pregnenolone Reduces L‐Dopa‐Induced Dyskinesias in Female Parkinsonian Monkeys
Movement Disorders, EarlyView.Pregnenolone is the first neurosteroid synthesized from cholesterol in the brain. Ovariectomized female monkeys were tested as a model of women in menopause. They were lesioned with MPTP modeling Parkinson's disease and treated with levodopa (L‐dopa) to induce dyskinesias.
Mélanie Bourque +5 more
wiley +1 more source
Toxicity of AMPA to the earthworm Eisenia andrei Bouché, 1972 in tropical artificial soil
Scientific Reports, 2016 Aminomethylphosphonic acid (AMPA) - one of glyphosate’s main metabolites - has been classified as persistent in soils, raising concern regarding the widespread use of glyphosate in agriculture and forestry. Glyphosate may have negative or neutral effects
A. Domínguez +7 more
semanticscholar +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra +3 more
wiley +1 more source
Copine-6 is a Ca2+ sensor for activity-induced AMPA receptor exocytosis
Cell Reports, 2023 Summary: The recruitment of synaptic α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors underlies the strengthening of neuronal connectivity during learning and memory. This process is triggered by N-methyl-D-aspartate (NMDA) receptor-
Jing Zhi Anson Tan +10 more
doaj
PLoS ONE, 2017 S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced glutamate's action at AMPA receptors on human and rat receptors and was inactive at NMDA and ...
Sylvie Bretin +18 more
doaj +1 more source
A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury
Neuroprotection, EarlyView.This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley +1 more source
Elucidating the Three‐Dimensional Structure of Piracetam through Rotational Spectroscopy
ChemistryOpen, EarlyView.Neutral molecules of the nootropic drug piracetam are generated by laser ablation and structurally characterized by microwave spectroscopy. Two conformers differing in the exo/endo configuration of the pyrrolidine ring are detected, with exo being the predominant form.
S. Mato +4 more
wiley +1 more source
Differential vesicular sorting of AMPA and GABAA receptors
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance In neurons most fast excitatory neurotransmission is mediated by AMPA receptors, which cluster at excitatory synapses primarily on dendritic spines. Fast synaptic inhibition is largely mediated by GABAA receptors, which cluster at inhibitory
YiRen Gu +7 more
semanticscholar +1 more source
Pest Management Science, EarlyView.This update examines exposure information for glyphosate in applicators and the general population published since 2020. The overall conclusions from these studies are that margins of exposure for applicators have not decreased since 2020 and still present de minimis risk.
Keith R. Solomon
wiley +1 more source