Results 91 to 100 of about 166,305 (364)

AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia. [PDF]

PLoS ONE, 2012
Several lines of evidence indicate altered trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors in schizophrenia. Previous reports have shown potential changes in the trafficking of AMPA receptors based on subunit expression
John C Hammond, James H Meador-Woodruff, Vahram Haroutunian, Robert E McCullumsmith   +3 more
doaj   +1 more source

State based model of long-term potentiation and synaptic tagging and capture [PDF]

, 2009
Recent data indicate that plasticity protocols have not only synapse-specific but also more widespread effects. In particular, in synaptic tagging and capture (STC), tagged synapses can capture plasticity-related proteins, synthesized in response to ...
A Govindarajan, A Hayer, AB Barrett, Adam B. Barrett, AJ Heynen, AM Zhabotinsky, B Hille, CCH Petersen, CM O'Carroll, D Amit, DH O'Connor, EM Izhikevich, Guy O. Billings, H Okamoto, HK Lee, HZ Shouval, HZ Shouval, JE Lisman, JR Whitlock, JW Lin, KG Reymann, Lyle J. Graham, M Graupner, M Krug, Mark C. W. van Rossum, NH Woo, P Miller, P Smolen, R Fonseca, R Fonseca, R Fonseca, Richard G. M. Morris, S Li, S Sajikumar, S Sajikumar, S Sajikumar, S Sajikumar, S Sajikumar, SJ Martin, SM Dudek, T Dunwiddie, U Frey, U Frey, U Frey, U Frey, U Staubli, W Senn, WC Abraham, WC Abraham, WS Sossin, Y Yao   +50 more
core   +5 more sources

Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning

Advanced Science, EarlyView.
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao, Guiyuan Shi, Ruixue Qin, Yinghao Sun, Wenbo Guo, Ruixia Shi, Minxian Peng, Jingxuan Yang, Jianjian Zhao, Qiuhan Liu, Jun Xiao, Ke Zhang, Qiang Liu, Wenxing Yang, He Liu   +14 more
wiley   +1 more source

GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

Frontiers in Molecular Neuroscience, 2012
The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov, Rolf eSprengel, Peter H Seeburg   +2 more
doaj   +1 more source

Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations [PDF]

, 2003
Electrical coupling between pyramidal cell axons, and between interneuron dendrites, have both been described in the hippocampus. What are the functional roles of the two types of coupling?
Bibbig, A., Buhl, E.H., Hormuzdi, S.G., LeBeau, F.E.N., Monyer, H., Pais, I., Traub, R.D., Whittington, M.A.   +7 more
core   +2 more sources

AMPA receptor trafficking and learning [PDF]

European Journal of Neuroscience, 2010
AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
J, Keifer, Z, Zheng
openaire   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals

The Journal of Headache and Pain, 2020
Background Purine receptors play roles in peripheral and central sensitization and are associated with migraine headache. We investigated the possibility that ATP plays a permissive role in the activation of AMPA receptors thus inducing Glu release from ...
Diego Currò, Pierluigi Navarra, Irene Samengo, Maria Martire   +3 more
doaj   +1 more source

AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury. [PDF]

, 2015
Clinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms ...
Beattie, Michael S, Bresnahan, Jacqueline C, Ferguson, Adam R, Grau, James W, Huie, J Russell, Irvine, Karen-Amanda, Lee, Kuan H, Stuck, Ellen D   +7 more
core   +1 more source

Uncorking AMPA receptors [PDF]

Journal of General Physiology, 2017
New JGP study explains how auxiliary proteins relieve polyamine block of AMPARs.
openaire   +1 more source