Results 121 to 130 of about 150,350 (378)

The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]

, 2017
The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro, Castellani, Angela, Giacomello, Marta, Lim, Dmitry, Mario, Agnese De, Massimino, Maria Lina, Peggion, Caterina, Sorgato, Maria Catia, Viviani, Francesca   +8 more
core   +1 more source

Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3

Proceedings of the National Academy of Sciences of the United States of America, 2016
Significance In Alzheimer’s disease, soluble clusters of amyloid-β (Aβ) are believed to degrade synapses and impair memory formation. The removal of AMPA receptors from synapses was previously shown to be a critical step in Aβ-driven synapse loss.
N. Reinders, Yvonne Pao, María C. Renner, Carla M. Da Silva-Matos, Tessa R. Lodder, R. Malinow, H. Kessels   +6 more
semanticscholar   +1 more source

Recent Findings on AMPA Receptor Recycling [PDF]

Frontiers in Cellular Neuroscience, 2018
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs) are tetrameric protein complexes that mediate most of the fast-excitatory transmission in response to the neurotransmitter glutamate in neurons. The abundance of AMPA-Rs at the surface of excitatory synapses establishes the strength of the response to glutamate. It is thus evident
Moretto Edoardo, Passafaro Maria
openaire   +6 more sources

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro [PDF]

Proc. Int. Works. Comp. Syst. Biol. TICSP series 8 (2011) 181-184, 2018
In this work we study the excitatory AMPA, and NMDA, and inhibitory GABAA receptor mediated dynamical changes in neuronal networks of neonatal rat cortex in vitro. Extracellular network-wide activity was recorded with 59 planar electrodes simultaneously under different pharmacological conditions.
arxiv  

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses

Frontiers in Molecular Neuroscience, 2018
Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros, Gladys L. Caldeira, Ana Luísa Carvalho, Ana Luísa Carvalho   +3 more
doaj   +1 more source

Intracellular machinery for the transport of AMPA receptors [PDF]

British Journal of Pharmacology, 2008
AMPA‐type glutamate receptors are one of the most dynamic components of excitatory synapses. Their regulated addition and removal from synapses leads to long‐lasting forms of synaptic plasticity, known as long‐term potentiation (LTP) and long‐term depression (LTD).
openaire   +5 more sources

Role of Glutamate Excitotoxicity in Glioblastoma Growth and Its Implications in Treatment

Cell Biology International, EarlyView.
ABSTRACT Glioblastoma is a highly malignant and invasive type of primary brain tumor that originates from astrocytes. Glutamate, a neurotransmitter in the brain plays a crucial role in excitotoxic cell death. Excessive glutamate triggers a pathological process known as glutamate excitotoxicity, leading to neuronal damage.
Colin Moriarty, Natasha Gupta, Debanjan Bhattacharya   +2 more
wiley   +1 more source

Fate of the organophosphate herbicide glyphosate in arable soils and its relationship to soil phosphorus status [PDF]

, 2009
Glyphosate is one of the world's most widely used herbicides. This study was undertaken to unravel the factors affecting its movement, sorption, persistence and leachability in different Finnish soils to create a sound basis for risk assessment. Field
Laitinen, Pirkko
core  

Seizure control by decanoic acid through direct AMPA receptor inhibition

Brain : a journal of neurology, 2015
See Rogawski (doi:10.1093/awv369) for a scientific commentary on this article.  The MCT ketogenic diet, an established treatment for drug-resistant epilepsy, leads to an elevation of plasma decanoic acid and ketones. Chang et al. show that decanoic acid,
P. Chang, Katrin Augustin, Kim Boddum, Sophie Williams, Minghao Sun, J. Terschak, J. Hardege, Philip E. Chen, M. Walker, Robin S. B. Williams   +9 more
semanticscholar   +1 more source