Results 121 to 130 of about 66,736 (230)
Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton +12 more
wiley +1 more source
Excitotoxicity through Ca2+-permeable AMPA receptors requires Ca2+-dependent JNK activation
, 2010 Marta Vieira +7 more
openalex +2 more sources
Laminar and cellular distribution of AMPA, kainate, and NMDA receptor subunits in monkey sensory-motor cortex [PDF]
, 1999 A. Mu�oz, Tom M. Woods, E.G. Jones
openalex +1 more source
Pra Desain Pabrik Bio Pellet dari Ampas Tebu (Bagasse) dengan Proses Torrefaction
, 2023 Bagas Hardiatmoko +3 more
openalex +2 more sources
Brain and Behavior, Volume 16, Issue 2, February 2026.This study included elderly people aged 60 and above in the NHANES 2011–2014 cycle. The research indicated that increased dietary decanoic acid intake was associated with better cognitive function in the elderly, among which diabetes and hypertension were statistically associated with a partial mediating effect, although causality cannot be inferred ...
Huangxin Zhu +4 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Frailty is a prevalent syndrome in older adults and is associated with increased vulnerability to adverse health outcomes. Growth differentiation factor 15 (GDF‐15), a cytokine involved in mitochondrial dysfunction and inflammation, has been proposed as a potential biomarker for age‐related conditions.
Juan Luis Sánchez‐Sánchez +6 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity
Protein Science, Volume 35, Issue 2, February 2026.Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin +3 more
wiley +1 more source
Efficient and rapid isolation of native AMPA receptor complexes for cryo‐EM
Protein Science, Volume 35, Issue 2, February 2026.Abstract Isolating native ion channels for structural characterization is routinely achieved by extraction from membrane fractions of tissue with prolonged mild detergent treatment. AMPA receptors (AMPARs), glutamatergic receptors that mediate fast excitatory transmission and synaptic plasticity, are coassembled with diverse auxiliary subunits and ...
Jumi Park, Eric Gouaux
wiley +1 more source