Results 51 to 60 of about 159,111 (333)

Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex

Scientific Reports, 2018
The establishment and maintenance of social dominance are critical for social stability and the survival and health of individual animals. Stress lead to depression and a decrease in the social status of depressed persons is a risk factor for suicide ...
Minjung Park, Bo Am Seo, Boyoung Lee, Hee-Sup Shin, Myoung-Goo Kang   +4 more
semanticscholar   +1 more source

Contribution of Prostaglandin E2‐Induced Neuronal Excitation to Drug Resistance in Glioblastoma Countered by a Novel Blood–Brain Barrier Crossing Celecoxib Derivative

Advanced Science, EarlyView.
Glioblastoma (GBM) is an aggressive brain cancer that often recurs and resists chemotherapy. This study found that a chemical called PGE2 causes surrounding brain cells (neurons) to become over‐excited, which makes GBM cells resistant to treatment. Researchers developed a new drug, “Compound 11,” which can cross into the brain and effectively block ...
Chih‐Jie Shen, Hsien‐Chung Chen, Chien‐Liang Lin, Amandeep Thakur, Raphael Onuku, I‐Chung Chen, Hao‐Yi Li, Kwang‐Yu Chang, Jian‐Ying Chuang, Wen‐Bin Yang, Hong‐Yi Lin, Yi‐Ru Shen, Jing‐Ping Liou, Wen‐Chang Chang, Tsung‐I Hsu   +14 more
wiley   +1 more source

Degradation of pesticides by the ligninolytic enzyme Laccase : optimisation of in vitro conditions, immobilisation and screening for natural mediators [PDF]

, 2013
Pesticides are widely used in many industries but the majority reaches non-target organisms or locations through point or diffuse sources. Understanding conditions for their degradation is therefore important.
Farragher, Naomi
core   +1 more source

What causes aberrant salience in schizophrenia? A role for impaired short-term habituation and the GRIA1 (GluA1) AMPA receptor subunit. [PDF]

, 2014
The GRIA1 locus, encoding the GluA1 (also known as GluRA or GluR1) AMPA glutamate receptor subunit, shows genome-wide association to schizophrenia. As well as extending the evidence that glutamatergic abnormalities have a key role in the disorder, this ...
Bannerman, D.M., Barkus, C., Harrison, P.J., Rawlins, J.N.P., Sanderson, D.J., Walton, M.E.   +5 more
core   +1 more source

Mechanisms of AMPA Receptor Endosomal Sorting [PDF]

Frontiers in Molecular Neuroscience, 2018
The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes.
Parkinson, Gabrielle T., Hanley, Jonathan G.   +1 more
openaire   +6 more sources

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

Advanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu, Peiran Zhao, Zheng Chen, Tianlei Ying, Zhihong Nie, Wei Hua, Huiyan Li, Ying Mao, Wenbo Bu   +8 more
wiley   +1 more source

Heroin-piracetam mixture: suggested mechanisms of action and risks of misinterpretation for drug users [PDF]

, 2017
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders.
Cappelletti, Simone, Ciallella, Costantino, Lombardo, Francesco, Vallone, Giuseppe, Vitale, Pasquale   +4 more
core   +1 more source

Structure and function of AMPA receptors [PDF]

The Journal of Physiology, 2004
The application of X‐ray diffraction has allowed the structure of the ligand‐binding core of AMPA receptors to be determined. Here I review the insights that this has given into the molecular mechanisms of activation and desensitization of these receptors.
openaire   +3 more sources

Advanced Brain‐on‐a‐Chip for Wetware Computing: A Review

Advanced Science, EarlyView.
Exploring Low‐Power, Beyond‐Silicon‐Computing Bio‐Computing: Brain‐on‐a‐Chip Technology. This article reviews the applications of Brain‐on‐a‐Chip in Wetware Computing, including in vitro‐cultured brain organoids, microelectrode arrays, electrophysiological interfaces, and microfluidic platforms, as well as data processing methods. It also looks forward
Shangchen Li, Yaoyao Liu, Sihan Hua, Yu Wang, Shutong Sun, Longhui Jiang, Chengji Lu, Juntao Liu, Huaizhang Shi, Pei Wu, Xinxia Cai, Jinping Luo   +11 more
wiley   +1 more source

Fate of the organophosphate herbicide glyphosate in arable soils and its relationship to soil phosphorus status [PDF]

, 2009
Glyphosate is one of the world's most widely used herbicides. This study was undertaken to unravel the factors affecting its movement, sorption, persistence and leachability in different Finnish soils to create a sound basis for risk assessment. Field
Laitinen, Pirkko
core