Results 61 to 70 of about 66,736 (230)

Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy [PDF]

, 2023
Tsuyoshi Eiro, Tomoyuki Miyazaki, Mai Hatano, Waki Nakajima, Tetsu Arisawa, Yuuki Takada, Kimito Kimura, Akane Sano, Kotaro Nakano, Takahiro Mihara, Yutaro Takayama, Naoki Ikegaya, Masaki Iwasaki, Akitoyo Hishimoto, Yoshihiro Noda, Takahiro Miyazaki, Hiroyuki Uchida, Hideaki Tani, Nobuhiro Nagai, Teruki Koizumi, Shinichiro Nakajima, Masaru Mimura, Nozomu Matsuda, Kazuaki Kanai, Kazuhiro Takahashi, Hiroshi Ito, Yoji Hirano, Yuichi Kimura, Riki Matsumoto, Akio Ikeda, Takuya Takahashi   +30 more
openalex   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Environmental aminomethylphosphonic acid (AMPA) exposure increased the risk of spontaneous abortion through lactate-induced JunB lactylation in trophoblast

Ecotoxicology and Environmental Safety
The etiology of spontaneous abortion (SA) is complex, and the underlying mechanisms remain largely elusive. Environmental toxins have been implicated in the increased occurrence of SA.
Chengcai Kong, Rong Li, Xiaoying Wang, Lijuan Li, Nannan Kang, Xin Zhen, Yishan Dong, Guijun Yan   +7 more
doaj   +1 more source

AMPA Receptors in NG2 Glia Differently Affect Signal Transduction in the Hippocampus and Cerebellum. [PDF]

Glia
Stronger expression of Ca2+ permeable AMPA receptors in cerebellar versus hippocampal NG2 glia. Different expression patterns of glial AMPA receptors and auxiliary subunits in both regions. Higher efficacy of neuron‐NG2 glia synapses in the cerebellum.
Tascio D, Gebril N, Jabs R, Henneberger C, Steinhäuser C, Seifert G.   +5 more
europepmc   +2 more sources

AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval [PDF]

, 2021
Magdalena Pereyra, Jorge H. Medina
openalex   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Atmospheric implications of aminomethylphosphonic acid promoted binary nucleation of water molecules

Chemical Thermodynamics and Thermal Analysis
Aminomethylphosphonic acid (AMPA) is the main metabolite of glyphosate and phosphonate, the major constituents of herbicides and insecticides used nowadays in modern agriculture and treatment of environmental refuge and sewage.
Ayiseh Frederick Tandong, Olivier Holtomo, David Afungchui   +2 more
doaj   +1 more source

Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors.

PLoS ONE, 2017
S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced glutamate's action at AMPA receptors on human and rat receptors and was inactive at NMDA and ...
Sylvie Bretin, Caroline Louis, Laure Seguin, Stéphanie Wagner, Jean-Yves Thomas, Sylvie Challal, Nathalie Rogez, Karine Albinet, Fabrice Iop, Nadège Villain, Sonia Bertrand, Ali Krazem, Daniel Bérachochéa, Stéphanie Billiald, Charles Tordjman, Alex Cordi, Daniel Bertrand, Pierre Lestage, Laurence Danober   +18 more
doaj   +1 more source

Efficacy and safety of perampanel as first adjunctive therapy in patients with focal‐onset seizures or generalized tonic‐clonic seizures in four post‐marketing studies across regions

Epilepsia Open, EarlyView.
Abstract Objective Early response to anti‐seizure medication (ASM) is associated with a favorable prognosis in patients with epilepsy. Research is required to confirm existing data on the clinical use of perampanel as first adjunctive therapy in different patient groups and different regions.
Stefano Meletti, Vineet Punia, Amitabh Dash, Anna Lisa Gentile, Ricardo Sáinz‐Fuertes, Samantha Goldman, Tobias Goldmann, Anna Patten, Dinesh Kumar, Leock Y. Ngo, Bernhard J. Steinhoff   +10 more
wiley   +1 more source

SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons

Neuroscience Research
Long-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
doaj   +1 more source