Results 61 to 70 of about 89,264 (312)

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

Cell Reports, 2012
AMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can modulate AMPA-R function in specific ways.
Natalie F. Shanks, Jeffrey N. Savas, Tomohiko Maruo, Ondrej Cais, Atsushi Hirao, Souichi Oe, Anirvan Ghosh, Yasuko Noda, Ingo H. Greger, John R. Yates, III, Terunaga Nakagawa   +10 more
doaj   +1 more source

Seminars in epileptology: How to diagnose status epilepticus in adults and children

Epileptic Disorders, EarlyView.
Abstract Status epilepticus (SE) can be regarded as the most severe expression of seizure activity characterized by a low probability of spontaneous cessation and mechanisms leading to metabolic and inflammatory derangements with increased risk of brain damage, alterations of neural networks, and potentially life‐threatening systemic complications ...
M. Leitinger, P. Bosque‐Varela, G. Kuchukhidze, U. Leitner, J. Höfler, G. Kalss, F. Rossini, G. Pilz, H. Novak, M. Mauritz, K. Poppert, A. Toma, E. Trinka   +12 more
wiley   +1 more source

Regulation of AMPA receptors in spinal nociception

Molecular Pain, 2010
The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studied in vitro and in vivo. The AMPA receptors present a unique characteristic
Lin Qing, Wu Zhiguo, Wu Jing, Wang Yun, Yue Yun, Fang Li   +5 more
doaj   +1 more source

Superactivation of AMPA receptors by auxiliary proteins [PDF]

Nature Communications, 2016
AbstractGlutamate receptors form complexes in the brain with auxiliary proteins, which control their activity during fast synaptic transmission through a seemingly bewildering array of effects. Here we devise a way to isolate the activation of complexes using polyamines, which enables us to show that transmembrane AMPA receptor regulatory proteins ...
Andrew J.R. Plested, Andrew J.R. Plested, Anna L. Carbone   +2 more
openaire   +4 more sources

Allosteric competition and inhibition in AMPA receptors

Nature Structural & Molecular Biology, 2023
AbstractExcitatory neurotransmission is principally mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-subtype ionotropic glutamate receptors (AMPARs). Negative allosteric modulators are therapeutic candidates that inhibit AMPAR activation and can compete with positive modulators to control AMPAR function through unresolved ...
W. Dylan Hale, Alejandra Montaño Romero, Cuauhtemoc U. Gonzalez, Vasanthi Jayaraman, Albert Y. Lau, Richard L. Huganir, Edward C. Twomey   +6 more
openaire   +3 more sources

Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study

Epilepsia Open, EarlyView.
Abstract Objective To investigate the efficacy and tolerability of perampanel (PER) on Dravet syndrome in China by a prospective real‐world study. Methods We prospectively enrolled children with Dravet syndrome from the neurology clinic of Shenzhen Children's Hospital from September 2020 to October 2021.
Han Wang, Hong Chen, Xin Ding, Xueyan Cao, Jiahui Mai, Huafang Zou, Dongfang Zou, Yanwei Zhu, Jianxiang Liao, Dezhi Cao   +9 more
wiley   +1 more source

Real‐world use of adjunctive perampanel for focal‐onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA)

Epilepsia Open, EarlyView.
Abstract Objective The AMPA study (Study 501; NCT04257604) was a multicenter, prospective, 12‐month observational study in Italy that evaluated the effectiveness and safety of adjunctive perampanel in patients with focal‐onset seizures (FOS), with or without focal to bilateral tonic–clonic seizures (FBTCS).
Alfredo D'Aniello, Anna Teresa Giallonardo, Paolo Tinuper, Oriano Mecarelli, Umberto Aguglia, Giovanni Assenza, Antonio Gambardella, Maria Paola Canevini, Renato Scifo, Stefano Meletti, Valentina De Giorgis, Enrica Bonanni, Roberto Michelucci, Caterina Cerminara, Antonino Romeo, Federico Vigevano, Francesca Felicia Operto, Luciana Tramacere, Giancarlo Di Gennaro, Alfonso Iudice on behalf of the AMPA Study group, Leock Y. Ngo, Anna Patten, Anna Lisa Gentile, Andrea Pecori, Samantha Goldman   +24 more
wiley   +1 more source

AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia. [PDF]

PLoS ONE, 2012
Several lines of evidence indicate altered trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors in schizophrenia. Previous reports have shown potential changes in the trafficking of AMPA receptors based on subunit expression
John C Hammond, James H Meador-Woodruff, Vahram Haroutunian, Robert E McCullumsmith   +3 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

Frontiers in Molecular Neuroscience, 2012
The GluA2 subunit in heteromeric AMPA receptor channels restricts Ca2+ permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels.
Andrei eRozov, Rolf eSprengel, Peter H Seeburg   +2 more
doaj   +1 more source