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Competitive AMPA Receptor Antagonists
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
CATARZI, DANIELA +2 more
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RNA aptamers for AMPA receptors
Neuropharmacology, 2021RNA aptamers are single-stranded RNA molecules, and they are selected against a target of interest so that they can bind to and modulate the activity of the target, such as inhibiting the target activity, with high potency and selectivity. Antagonists, such as RNA aptamers, acting on AMPA receptors, a major subtype of ionotropic glutamate receptors ...
Zhen Huang, Li Niu
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Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins
Neuroscience, 2009The AMPA receptors are ligand-gated ion channels belonging to the family of ionotropic glutamate receptors. They play an essential role in fast excitatory synaptic transmission in the CNS of vertebrates. Their activity-dependent directed transport and fast turnover at the plasma membrane contribute to synaptic plasticity and require numerous ...
C, Sager +3 more
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Neurology, 2016
In this and forthcoming reviews, a representative clinical case will serve as an introduction to the topic to be discussed. This will provide the basis to address some recent insights from basic neuroscience research on the normal function of the primary target of the disease process involved in the case presented, as well as putative pathophysiologic ...
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In this and forthcoming reviews, a representative clinical case will serve as an introduction to the topic to be discussed. This will provide the basis to address some recent insights from basic neuroscience research on the normal function of the primary target of the disease process involved in the case presented, as well as putative pathophysiologic ...
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Inhibitors of AMPA and Kainate Receptors
Current Medicinal Chemistry, 2001The glutamate receptor system is implicated in the development and maintenance of epileptic seizures, and animal studies have disclosed potent anticonvulsant activity of a number of inhibitors of AMPA and/or kainate (KA) receptor activity. These results make such inhibitors potential future antiepileptic drugs.
U, Madsen +2 more
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AMPA Receptor Cycling in the Synapse
Science's STKE, 2004Ionotropic glutamate receptors (GluRs) are involved in mediating signaling in response to synaptic activity. In addition to converting the chemical signal released from the presynaptic terminal to an electrical response in the postsynaptic neuron, these receptors are critically involved in activity-dependent, long-term changes in synaptic strength and,
Anis, Contractor, Stephen F, Heinemann
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Sensitivity of AMPA receptors to pentobarbital
European Journal of Pharmacology: Molecular Pharmacology, 1994The inhibitory effects of pentobarbital on various AMPA receptors expressed (GluR1, GluR3, GluR1/3, GluR1/2, and GluR2/3) in Xenopus oocytes were examined. Combinations of AMPA receptor subunits that included GluR2 demonstrated a much higher sensitivity to blockade by this barbiturate and the apparent co-operativity of the interaction of pentobarbital ...
F A, Taverna +4 more
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A Family of AMPA-Selective Glutamate Receptors
Science, 1990Four cloned cDNAs encoding 900-amino acid putative glutamate receptors with approximately 70 percent sequence identity were isolated from a rat brain cDNA library. In situ hybridization revealed differential expression patterns of the cognate mRNAs throughout the brain.
Keinänen, K. +7 more
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The AMPA receptors of auditory neurons
Hearing Research, 2000The ionotropic glutamate receptor (GluR) subtype known as the AMPA receptor, which mediates rapid excitatory synaptic transmission in many regions of the nervous system, is composed of four different protein subunits, termed GluRs 1-4. The functional properties of each AMPA receptor are determined by the relative levels of GluRs 1-4 and by post ...
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Current Pharmaceutical Design, 1996
AMPA and kainate receptors belong to a common family of ionotropic glutamate receptors. Molecular biology has revealed some of the molecular features that are responsible for selective ion permeability of the receptor comp.lex. The diversity of subunits and their combination into hetero-oligomeric recep or complexes have provided evidence that ...
Christopher F. Bigge +2 more
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AMPA and kainate receptors belong to a common family of ionotropic glutamate receptors. Molecular biology has revealed some of the molecular features that are responsible for selective ion permeability of the receptor comp.lex. The diversity of subunits and their combination into hetero-oligomeric recep or complexes have provided evidence that ...
Christopher F. Bigge +2 more
openaire +1 more source