Results 41 to 50 of about 2,334,241 (398)

Control of AMPA receptor activity by the extracellular loops of auxiliary proteins

eLife, 2017
At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for
Irene Riva, Clarissa Eibl, Rudolf Volkmer, Anna L Carbone, Andrew JR Plested   +4 more
doaj   +1 more source

Increased accuracy of ligand sensing by receptor diffusion on cell surface [PDF]

Physical Review E 82, 041902 (2010), 2010
The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral diffusion of receptors on the cell membrane affects the accuracy of sensing ligand concentration.
arxiv   +1 more source

Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy

Science, 2016
Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory.
E. C. Twomey, M. Yelshanskaya, R. Grassucci, J. Frank, A. Sobolevsky   +4 more
semanticscholar   +1 more source

Topiramate and other kainate receptor antagonists for depression: A systematic review of randomized controlled trials

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 421-429, December 2022., 2022
Abstract Background Depression is a common disorder that affects patients' quality of life and incurs health system costs. Due to the resistance to treat depression, better understanding of neurophysiology was considered; one of the implications is the glutamatergic system.
Ahmad Shamabadi
wiley   +1 more source

Transmembrane AMPA receptor regulatory proteins and AMPA receptor function in the cerebellum

Neuroscience, 2009
Heterogeneity among AMPA receptor (AMPAR) subtypes is thought to be one of the key postsynaptic factors giving rise to diversity in excitatory synaptic signaling in the CNS. Recently, compelling evidence has emerged that ancillary AMPAR subunits-the so-called transmembrane AMPA receptor regulatory proteins (TARPs)-also play a vital role in influencing ...
Ian D. Coombs, Stuart G. Cull-Candy
openaire   +3 more sources

Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β‐amyloid peptide (25–35)‐induced memory impairment in mice

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 492-501, December 2022., 2022
Abstract Aim We previously reported that oxytocin, a peptide hormone, can reverse the β‐amyloid peptide (25–35) (Aβ25–35)‐induced impairments of the murine hippocampal synaptic plasticity. In this study, we examined the effects of oxytocin on the Aβ25–35‐induced impairment of cognitive behavior in murine in order to investigate the potential of ...
Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki‐Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun‐Ichiro Oka   +8 more
wiley   +1 more source

Differences in AMPA and Kainate Receptor Interactomes Facilitate Identification of AMPA Receptor Auxiliary Subunit GSG1L

Cell Reports, 2012
AMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can modulate AMPA-R function in specific ways.
Natalie F. Shanks, Jeffrey N. Savas, Tomohiko Maruo, Ondrej Cais, Atsushi Hirao, Souichi Oe, Anirvan Ghosh, Yasuko Noda, Ingo H. Greger, John R. Yates, III, Terunaga Nakagawa   +10 more
doaj   +1 more source

Analytical modelling of temperature effects on synapses [PDF]

Kufel, D. S., & Wojcik, G. M. (2018). Analytical modelling of temperature effects on an AMPA-type synapse. Journal of computational neuroscience, 44(3), 379-391, 2016
It was previously reported, that temperature may significantly influence neural dynamics on different levels of brain modelling. Due to this fact, while creating the model in computational neuroscience we would like to make it scalable for wide-range of various brain temperatures. However currently, because of a lack of experimental data and an absence
arxiv   +1 more source

Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3R [PDF]

, 2015
Adenosine is a widespread neuromodulator within the CNS and its extracellular level is increased during hypoxia or intense synaptic activity, modulating pre- and postsynaptic sites.
BERTOLLINI, Cristina, DI ANGELANTONIO, SILVIA, LIMATOLA, Cristina, PAGANI, FRANCESCA, PICCININ, Sonia, RAGOZZINO, Davide Antonio, ROSITO, MARIA, TRETTEL, Flavia   +7 more
core   +1 more source

3D-QSAR studija afiniteta vezanja na receptor za (R,S)-2-amino-3-(3-hidroksi-5-metilizoksazol-4-il)-propansku kiselinu [PDF]

, 2008
An approach for binding affinity evaluation is suggested and exemplified using a set of triazolo [1,5-a] quinoxaline for the (R,S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)-propionic acid (AMPA) receptor.
HARDIK THAKAR, KAMALA K. VASU, RITESH N. SHARMA, SUBHASH C. CHATURVEDI   +3 more
core   +2 more sources