Evolutionarily conserved pattern of AMPA receptor subunit glycosylation in Mammalian frontal cortex. [PDF]
PLoS ONE, 2014 Protein glycosylation may contribute to the evolution of mammalian brain complexity by adapting excitatory neurotransmission in response to environmental and social cues.
Janusz Tucholski +3 more
doaj +1 more source
Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model
Life Science Alliance, 2022 RNA aptamers designed to block AMPA receptors effectively reduce progression of motor dysfunction, improve TDP-43 pathology, and prevent death of motor neurons in AR2 mice, a mouse model of sporadic ALS, without adverse effects.
Megumi Akamatsu +7 more
doaj +1 more source
Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]
, 2009 NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S. +8 more
core +1 more source
Gating Modes in AMPA Receptors [PDF]
The Journal of Neuroscience, 2010 AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and
Martin Loynaz, Prieto +1 more
openaire +2 more sources
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
doaj +1 more source
AMPA receptor trafficking and learning [PDF]
European Journal of Neuroscience, 2010 AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
J, Keifer, Z, Zheng
openaire +2 more sources
Control of AMPA receptor activity by the extracellular loops of auxiliary proteins
eLife, 2017 At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for
Irene Riva +4 more
doaj +1 more source
Differential localization of glutamate receptor subunits at the drosophila neuromuscular junction [PDF]
, 2004 The subunit composition of postsynaptic neurotransmitter receptors is a key determinant of synaptic physiology. Two glutamate receptor subunits, Drosophila glutamate receptor IIA (DGluRIIA) and DGluRIIB, are expressed at the Drosophila neuromuscular ...
Portman, Scott L. +5 more
core +1 more source
Recurrent Anti-AMPA Receptor Limbic Encephalitis: A Case Report and Literature Review
Frontiers in Neurology, 2021 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is a relatively rare anti-neuronal surface antigen autoimmune encephalitis (LE).
Yuanyuan Fang, Dengji Pan, Hao Huang
doaj +1 more source
Age-dependent remodelling of ionotropic signalling in cortical astroglia [PDF]
, 2011 Cortical astrocytes express fast ionotropic receptors for glutamate and ATP, although their role in neurone-glia communication remains controversial.
Lalo, Ulyana +11 more
core +1 more source