Results 21 to 30 of about 50,502 (231)
Control of AMPA receptor activity by the extracellular loops of auxiliary proteins
eLife, 2017 At synapses throughout the mammalian brain, AMPA receptors form complexes with auxiliary proteins, including TARPs. However, how TARPs modulate AMPA receptor gating remains poorly understood. We built structural models of TARP-AMPA receptor complexes for
Irene Riva +4 more
doaj +1 more source
Recurrent Anti-AMPA Receptor Limbic Encephalitis: A Case Report and Literature Review
Frontiers in Neurology, 2021 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor encephalitis is a relatively rare anti-neuronal surface antigen autoimmune encephalitis (LE).
Yuanyuan Fang, Dengji Pan, Hao Huang
doaj +1 more source
Cell Reports, 2012 AMPA receptor (AMPA-R) complexes consist of channel-forming subunits, GluA1-4, and auxiliary proteins, including TARPs, CNIHs, synDIG1, and CKAMP44, which can modulate AMPA-R function in specific ways.
Natalie F. Shanks +10 more
doaj +1 more source
Reduced Effect of Anticonvulsants on AMPA Receptor Palmitoylation-Deficient Mice
Frontiers in Pharmacology, 2021 AMPA receptors are responsible for fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor subunits GluA1-4 reversibly regulates synaptic AMPA receptor expression, resulting in long ...
Madoka Iizumi +4 more
doaj +1 more source
Membrane lipid rafts are required for AMPA receptor tyrosine phosphorylation
Frontiers in Synaptic Neuroscience, 2022 Membrane lipid rafts are sphingolipids and cholesterol-enriched membrane microdomains, which form a center for the interaction or assembly of palmitoylated signaling molecules, including Src family non-receptor type protein tyrosine kinases.
Takashi Hayashi, Takashi Hayashi
doaj +1 more source
Cell Reports, 2017 Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity.
Sylvia Pfennig +6 more
doaj +1 more source
AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval
Frontiers in Human Neuroscience, 2021 Retrieval constitutes a highly regulated and dynamic phase in memory processing. Its rapid temporal scales require a coordinated molecular chain of events at the synaptic level that support transient memory trace reactivation.
Magdalena Pereyra +3 more
doaj +1 more source
Nomadic AMPA Receptors and LTP [PDF]
Neuron, 1999 What are the broader implications of these two reports? One feature of LTP is its reversibility: once established, application of low-frequency stimulus train can decrease the synaptic strength. When applied to naive synapyses (i.e., in fresh brain slices), such low frequency stimulation induces a long-lasting depression of synaptic responses known as ...
Morales, Miguel, Goda, Yukiko
openaire +2 more sources
Desensitization dynamics of the AMPA receptor
Structure, 2023 To perform their physiological functions, amino methyl propionic acid receptors (AMPARs) cycle through active, resting, and desensitized states, and dysfunction in AMPAR activity is associated with various neurological disorders. Transitions among AMPAR functional states, however, are largely uncharacterized at atomic resolution and are difficult to ...
Jussi Aittoniemi +3 more
openaire +2 more sources
AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures.
PLoS ONE, 2011 Ionotropic glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of fast synaptic neurotransmission.
Cesare Orlandi +6 more
doaj +1 more source