Results 41 to 50 of about 1,291,656 (247)

GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse

Cell Reports, 2017
Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity.
Sylvia Pfennig, Franziska Foss, Diane Bissen, Eva Harde, Julia C. Treeck, Marta Segarra, Amparo Acker-Palmer   +6 more
doaj   +1 more source

AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval

Frontiers in Human Neuroscience, 2021
Retrieval constitutes a highly regulated and dynamic phase in memory processing. Its rapid temporal scales require a coordinated molecular chain of events at the synaptic level that support transient memory trace reactivation.
Magdalena Pereyra, Jorge H. Medina, Jorge H. Medina, Jorge H. Medina   +3 more
doaj   +1 more source

AMPA receptor regulation at the mRNA and protein level in rat primary cortical cultures.

PLoS ONE, 2011
Ionotropic glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of fast synaptic neurotransmission.
Cesare Orlandi, Luca La Via, Daniela Bonini, Cristina Mora, Isabella Russo, Alessandro Barbon, Sergio Barlati   +6 more
doaj   +1 more source

SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons

Neuroscience Research
Long-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Misaki Morishita, Shinji Matsuda
doaj   +1 more source

Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

Scientific Reports, 2017
AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor ...
Maria V. Yelshanskaya, Samaneh Mesbahi-Vasey, Maria G. Kurnikova, Alexander I. Sobolevsky   +3 more
doaj   +1 more source

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice

Frontiers in Cellular Neuroscience, 2013
Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari, Walter eNahm, Jeffrey eNoebels   +2 more
doaj   +1 more source

The early stage formation of PI3K-AMPAR GluR2 subunit complex facilitates the long term neuroprotection induced by propofol post-conditioning in rats.

PLoS ONE, 2013
Previously, we have shown that the phosphoinositide-3-kinase (PI3K) mediated acute (24 h) post-conditioning neuroprotection induced by propofol.
Haiyun Wang, Guolin Wang, Chenxu Wang, Ying Wei, Zhiting Wen, Chunyan Wang, Ai Zhu   +6 more
doaj   +1 more source

Molecular pharmacology of AMPA receptor trafficking proteins - TARPs - evidence for an association with 5HT(_2c) receptors [PDF]

, 2009
There has been an increasing awareness of the involvement of neurotransmitters other than serotonin in depression, with new antidepressants possessing effects on other receptor types, such as Agomelatine®, an antagonist of 5HT(_2c) receptors that ...
Donoghue, Peter, Donoghue , Peter
core  

Data_Sheet_3_Molecular Characterization of AMPA-Receptor-Containing Vesicles.PDF

, 2021
Regulated delivery of AMPA receptors (AMPARs) to the postsynaptic membrane is an essential step in synaptic strength modification, and in particular, long-term potentiation (LTP).
John Jacob Peters (11567953), Jeremy Leitz (11567956), Axel T. Brunger (246500), Juan A. Oses-Prieto (1317723), Alma L. Burlingame (81810)   +4 more
core   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source