Exploring the impact of the stargazin V143L mutation on the dynamics of the AMPA receptor: stargazin complex [PDF]
Frontiers in Cellular NeuroscienceStargazin, a transmembrane AMPAR regulatory protein (TARP), plays a crucial role in facilitating the transport of AMPA receptors to the cell surface, stabilising their localisation at synapses and influencing their gating properties.
Raquel P Gouveia +2 more
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Superactivation of AMPA receptors by auxiliary proteins [PDF]
Nature Communications, 2016 Transmembrane AMPA receptor regulatory proteins (TARPs) exert a number of effects on fast glutamatergic synaptic transmission. Here, the authors model the interactions of two such proteins, Stargazin and γ-8, and propose a simple kinetic mechanism by ...
Anna L. Carbone, Andrew J. R. Plested
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The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex [PDF]
eLife, 2023 Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity.
Edoardo Moretto +7 more
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Molecular cloning of the gene promoter encoding the human CaVγ2/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pathway [PDF]
Frontiers in Physiology, 2023 CaVγ2 (Stargazin or TARPγ2) is a protein expressed in various types of neurons whose function was initially associated with a decrease in the functional expression of voltage-gated presynaptic Ca2+ channels (CaV) and which is now known to promote the ...
David Muñoz-Herrera +9 more
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Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling [PDF]
Frontiers in Molecular Neuroscience, 2023 The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-
Martino Avallone +13 more
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Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin
Neurobiology of Disease, 2008 Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and ...
Kim L Powell +2 more
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Targeted sensors for glutamatergic neurotransmission [PDF]
eLife, 2023 Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available.
Yuchen Hao +4 more
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Stargazin Modulation of AMPA Receptors
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Garam Lee +2 more
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The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation [PDF]
Frontiers in Molecular Neuroscience, 2022 Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry.
Beulah Leitch
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Regulation of the Stability and Localization of Post-synaptic Membrane Proteins by Liquid-Liquid Phase Separation [PDF]
Frontiers in Physiology, 2021 Synaptic plasticity is a cellular mechanism of learning and memory. The synaptic strength can be persistently upregulated or downregulated to update the information sent to the neuronal network and form a memory engram.
Tomohisa Hosokawa, Pin-Wu Liu
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