Results 1 to 10 of about 116 (96)
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
David Maclean +2 more
exaly +6 more sources
Frontiers in Cellular NeuroscienceStargazin, a transmembrane AMPAR regulatory protein (TARP), plays a crucial role in facilitating the transport of AMPA receptors to the cell surface, stabilising their localisation at synapses and influencing their gating properties.
Raquel Pina Gouveia +2 more
exaly +5 more sources
Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses [PDF]
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Ana Luisa Carvalho, Gladys L Caldeira
exaly +6 more sources
A Role for Stargazin in Experience-Dependent Plasticity
Cell Reports, 2014 During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Susana R. Louros +4 more
doaj +4 more sources
Genetic absence epilepsy rats from Strasbourg have increased corticothalamic expression of stargazin
Neurobiology of Disease, 2008 Stargazin is membrane bound protein involved in trafficking, synapse anchoring and biophysical modulation of AMPA receptors. A quantitative trait locus in chromosome 7 containing the stargazin gene has been identified as controlling the frequency and ...
Christopher Reid, Kim Powell
exaly +3 more sources
Molecular Mechanism of AMPA Receptor Modulation by TARP/Stargazin [PDF]
Neuron, 2017 AMPA receptors (AMPARs) mediate the majority of fast excitatory transmission in the brain and critically contribute to synaptic plasticity and pathology. AMPAR trafficking and gating are tightly controlled by auxiliary transmembrane AMPAR regulatory proteins (TARPs).
Mohammad Qneibi +2 more
exaly +3 more sources
Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics [PDF]
Journal of Biological Chemistry, 2006 Stargazin is an accessory protein of AMPA receptors that enhances surface expression and also affects the biophysical properties of the receptor. AMPA receptor domains necessary for either of these two processes have not yet been identified. Here, we used confocal imaging and electrophysiology of heterologously expressed, fluorophore-tagged GluR1 ...
Kathryn Partin
exaly +3 more sources
Calpain-mediated regulation of stargazin in adult rat brain [PDF]
Neuroscience, 2011 Changes in AMPA receptors have been proposed to underlie changes in synaptic efficacy in hippocampus and other brain structures. Calpain activation has also been discussed as a potential mechanism to produce lasting modifications of synaptic structure and function.
Xiaoning Bi, Michel Baudry
exaly +3 more sources
Neurobiology of Disease, 2011 Absence-like seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model are believed to arise in hyperexcitable somatosensory cortical neurons, however the cellular basis of this increased excitability remains unknown. We have previously
Christopher Reid, Kim Powell
exaly +3 more sources
A novel action of stargazin as an enhancer of AMPA receptor activity
Neuroscience Research, 2004 Stargazin (gamma-2) is disrupted in the ataxic and epileptic mutant mouse, stargazer (stg). The striking defect in the stg cerebellum is the lack of functional AMPA receptors on granule cells. Recently, it has been reported that gamma-2 and its related molecules are crucial for the surface expression, synaptic targeting and recycling of AMPA receptors,
Masahiko Watababe +2 more
exaly +4 more sources