Results 41 to 50 of about 1,561 (160)
Slow excitatory synaptic currents generated by AMPA receptors
The Journal of Physiology, Volume 600, Issue 2, Page 217-232, 15 January 2022., 2022 Abstract figure legend Besides their classical fast responses that depress with repeated stimulation (blue), some forms of AMPA‐type glutamate receptors can produce a current with slow kinetics approaching 0.5 s. A progressive increase in the current (‘pedestal’, orange) produces short‐term potentiation from a postsynaptic locus.
Niccolò P. Pampaloni +1 more
wiley +1 more source
The Journal of Physiology, Volume 600, Issue 2, Page 201-215, 15 January 2022., 2022 Abstract figure legend Retinogeniculate synapses of the dLGN are large synapses with multiple release sites. Pronounced short‐term depression of currents in retinogeniculate synapses results from high release probability and desensitization of AMPA receptors.
Jakob von Engelhardt
wiley +1 more source
High-affinity anti-Arc nanobodies provide tools for structural and functional studies
PLoS ONE, 2022 Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals.
Sigurbjörn Markússon +9 more
doaj +3 more sources
Targeted sensors for glutamatergic neurotransmission
eLife, 2023 Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available.
Yuchen Hao +4 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7418-7425, August 2021., 2021 Abstract We previously showed a hydroxamic acid‐based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen‐glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions.
Yao‐Ching Fang +7 more
wiley +1 more source
Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]
Biophysical Journal, 2014 AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Carbone, Anna L., Plested, Andrew J.
openaire +1 more source
iScience, 2022 Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen +9 more
doaj +1 more source
Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease
The Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021 Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley +1 more source
Stargazin controls the pharmacology of AMPA receptor potentiators [PDF]
Proceedings of the National Academy of Sciences, 2006 Glutamate is the major excitatory neurotransmitter in brain, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, and their deactivation and desensitization determine the timing of synaptic transmission.
Susumu, Tomita +4 more
openaire +2 more sources
Aging Cell, Volume 20, Issue 4, April 2021., 2021 Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera +6 more
wiley +1 more source