Results 41 to 50 of about 2,605 (175)

Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition

Cells, 2022
The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. AMPARs have four different subunits, GluA1–4 (each encoded by different genes, Gria1, Gria2, Gria3 and Gria4), that can form distinct ...
Sophie J. F. van der Spek, Nikhil J. Pandya, Frank Koopmans, Iryna Paliukhovich, Roel C. van der Schors, Mylene Otten, August B. Smit, Ka Wan Li   +7 more
doaj   +1 more source

Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons [PDF]

, 2017
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Circuit computation requires precision in the timing, extent, and synchrony of principal cell (PC) firing that is largely enforced by ...
Barksdale, E, Cameron, HA, Chittajallu, R, Colonnese, MT, Craig, MT, Karlsson, R-M, McBain, CJ, Mitchell, RM, Murata, Y, Pelkey, KA, Petralia, RS, Sukumaran, M, Vargish, GA, Worley, PF, Wyeth, MS, Yuan, X   +15 more
core   +1 more source

Synaptic Changes in AMPA Receptor Subunit Expression in Cortical Parvalbumin Interneurons in the Stargazer Model of Absence Epilepsy

Frontiers in Molecular Neuroscience, 2017
Feedforward inhibition is essential to prevent run away excitation within the brain. Recent evidence suggests that a loss of feed-forward inhibition in the corticothalamocortical circuitry may underlie some absence seizures.
Nadia K. Adotevi, Beulah Leitch
doaj   +1 more source

TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs [PDF]

, 2013
Regulation of calcium-permeable AMPA receptors (CP-AMPARs) is crucial in normal synaptic function and neurological disease states. Although transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2) modulate the properties of calcium ...
A Priel, A Rozov, AC Jackson, AS Kato, AS Kato, B Liu, B Sommer, C Bats, C Bats, C Chung, CA Schneider, CH Cho, D Bowie, D Soto, D Soto, D Turetsky, D Yan, Dorota Studniarczyk, HY Man, Ian Coombs, J Mosbacher, J Schwenk, JJ Rosenthal, JR Geiger, JS Park, JT Isaac, K Hashimoto, K Menuz, KS Kim, L Cathala, L Chen, L Ferron, M Blaschke, M Fukaya, M Hollmann, M Koike, M Passafaro, M Yamazaki, MA Bedoukian, Mark Farrant, MS Washburn, N Burnashev, N Rouach, R Kuner, S Cull-Candy, S Kott, S Tomita, S Tomita, SF Traynelis, SF Traynelis, SJ Liu, SM Gardner, SN Kudoh, SQJ Liu, Stuart G Cull-Candy, V Gallo, V Gangadharan, VA Letts, Y Shi, Y Shi   +59 more
core   +1 more source

TARP γ-2 is required for inflammation-associated AMPA receptor plasticity within lamina II of the spinal cord dorsal horn [PDF]

, 2017
In the brain, transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) critically influence the distribution, gating, and pharmacology of AMPARs, but the contribution of these auxiliary subunits to AMPAR-mediated signaling in the spinal cord ...
Cull-Candy, SG, Farrant, M, Sullivan, SJ
core   +1 more source

Auxiliary subunits keep AMPA receptors compact during activation and desensitization

eLife, 2018
Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
doaj   +1 more source

PKC Anchoring to GluR4 AMPA Receptor Subunit Modulates PKC‐Driven Receptor Phosphorylation and Surface Expression [PDF]

, 2007
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91156/1/j.1600-0854.2006.00521.x ...
Allison, Barria, Bayer, Boehm, Carvalho, Carvalho, Carvalho, Chen, Colbran, Coleman, Colledge, Condorelli, Correia, Duarte, Duarte, Esteban, Ghosh, Gomes, Grunder, Hayashi, Hayashi, Hoover, Kim, Kreimborg, Laemmli, Malenka, Malinow, Man, Nuriya, Passafaro, Ravindranathan, Rego, Rosenmund, Shen, Shi, Snyder, Song, Tomita, Tomita, Turetsky, Vandenberghe, Vandenberghe, Zhu   +42 more
core   +3 more sources

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice

Frontiers in Cellular Neuroscience, 2013
Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari, Walter eNahm, Jeffrey eNoebels   +2 more
doaj   +1 more source

Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates [PDF]

, 2009
After denervation of adult rat abdominal muscles, the postsynaptic apparatus of neuromuscular junctions (NMJs) retains its original architecture and clustering of acetylcholine receptors (AChRs).
A. BARBON, BAIGUERA C, BARLATI S, BORONI F, BRUNELLI G, BUFFELLI M, CAMBIANICA I, CLEMENTI F, ETTORRE M, FRANCOLINI M, GUARNERI B, LA VIA L, LANZILLOTTA A, PIZZI M, SPANO PF   +14 more
core   +1 more source

LGI1 downregulation increases neuronal circuit excitability

Epilepsia, Volume 61, Issue 12, Page 2836-2846, December 2020., 2020
Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1) is a secreted transsynaptic protein that interacts presynaptically with Kv1.1 potassium channels and a disintegrin and metalloprotease (ADAM) protein 23, and postsynaptically influences α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors through a direct link with the ADAM22 cell ...
Eleonora Lugarà, Rahul Kaushik, Marco Leite, Elodie Chabrol, Alexander Dityatev, Gabriele Lignani, Matthew C. Walker   +6 more
wiley   +1 more source