Results 41 to 50 of about 1,542 (158)
Stargazin controls the pharmacology of AMPA receptor potentiators [PDF]
Proceedings of the National Academy of Sciences, 2006 Glutamate is the major excitatory neurotransmitter in brain, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, and their deactivation and desensitization determine the timing of synaptic transmission.
Susumu, Tomita +4 more
openaire +2 more sources
Aging Cell, Volume 20, Issue 4, April 2021., 2021 Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera +6 more
wiley +1 more source
Frontiers in Molecular Neuroscience, 2022 Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry.
Beulah Leitch
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Neural Plasticity, Volume 2021, Issue 1, 2021., 2021 Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity‐regulated cytoskeleton‐associated protein (Arc) is a master regulator
Michal Fila +5 more
wiley +1 more source
Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]
PLoS ONE, 2017 AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya +6 more
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Frontiers in Physiology, 2021 Synaptic plasticity is a cellular mechanism of learning and memory. The synaptic strength can be persistently upregulated or downregulated to update the information sent to the neuronal network and form a memory engram.
Tomohisa Hosokawa, Pin-Wu Liu
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Cells, 2022 The AMPA glutamate receptor (AMPAR) is the major type of synaptic excitatory ionotropic receptor in the brain. AMPARs have four different subunits, GluA1–4 (each encoded by different genes, Gria1, Gria2, Gria3 and Gria4), that can form distinct ...
Sophie J. F. van der Spek +7 more
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Frontiers in Molecular Neuroscience, 2017 Feedforward inhibition is essential to prevent run away excitation within the brain. Recent evidence suggests that a loss of feed-forward inhibition in the corticothalamocortical circuitry may underlie some absence seizures.
Nadia K. Adotevi, Beulah Leitch
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Auxiliary subunits keep AMPA receptors compact during activation and desensitization
eLife, 2018 Signal transduction at vertebrate excitatory synapses involves the rapid activation of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptors, glutamate-gated ion channels whose four subunits assemble as a dimer-of-dimers.
Jelena Baranovic, Andrew JR Plested
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Frontiers in Cellular Neuroscience, 2013 Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari +2 more
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