Results 51 to 60 of about 2,605 (175)
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]
Science, 2016 Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
Edward C, Twomey +4 more
openaire +2 more sources
Aggregation Limits Surface Expression of Homomeric GluA3 Receptors [PDF]
, 2016 AMPA receptors are glutamate-gated cation channels assembled from GluA1-4 subunits and have properties that are strongly dependent on the subunit composition.
Ahmed +44 more
core +1 more source
Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution [PDF]
Nature Neuroscience, 2009 Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in
Helmut W, Kessels +3 more
openaire +2 more sources
BMC Neuroscience, 2003 Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Dolphin Annette C +2 more
doaj +1 more source
AMPA Receptor Trafficking and the Control of Synaptic Transmission [PDF]
, 2001 Modificacions aprovades pel Plenari del Consell Municipal el 28-01 ...
Ajuntament de Barcelona +2 more
core +1 more source
Further characterization of regulation of CaV2.2 by Stargazin [PDF]
Channels, 2010 Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the γ₁ subunit of skeletal muscle calcium channels. It was thus termed γ₂ subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated.
Isabella, Tselnicker, Nathan, Dascal
openaire +2 more sources
A Myosin Va Mutant Mouse with Disruptions in Glutamate Synaptic Development and Mature Plasticity in Visual Cortex [PDF]
, 2017 Myosin Va (MyoVa) mediates F-actin-based vesicular transport toward the plasma membrane and is found at neuronal postsynaptic densities (PSDs), but the role of MyoVa in synaptic development and function is largely unknown.
Constantine-Paton, Martha +4 more
core +1 more source
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]
Neuron, 2017 AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
Hsin-Wei, Lu +3 more
openaire +2 more sources
Proteomic Analysis of Postsynaptic Protein Complexes Underlying Neuronal Plasticity [PDF]
, 2017 Normal neuronal communication and synaptic plasticity at glutamatergic synapses requires dynamic regulation of postsynaptic molecules. Protein expression and protein post-translational modifications regulate protein interactions that underlie this ...
Baucum, Anthony J., II
core +1 more source
A protein interaction based model for schizophrenia study [PDF]
, 2008 Background Schizophrenia is a complex disease with multiple factors contributing to its pathogenesis. In addition to environmental factors, genetic factors may also increase susceptibility.
Liu Chih-Min +5 more
core +2 more sources