Results 51 to 60 of about 1,542 (158)
LGI1 downregulation increases neuronal circuit excitability
Epilepsia, Volume 61, Issue 12, Page 2836-2846, December 2020., 2020 Abstract Objective Leucine‐rich glioma‐inactivated 1 (LGI1) is a secreted transsynaptic protein that interacts presynaptically with Kv1.1 potassium channels and a disintegrin and metalloprotease (ADAM) protein 23, and postsynaptically influences α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptors through a direct link with the ADAM22 cell ...
Eleonora Lugarà +6 more
wiley +1 more source
Further characterization of regulation of CaV2.2 by Stargazin [PDF]
Channels, 2010 Stargazin, a transmembrane protein expressed in the nervous system, shares similarities with the γ₁ subunit of skeletal muscle calcium channels. It was thus termed γ₂ subunit of neuronal calcium channels. Stargazin downregulates the expression of Ca(V)2 channels, however, its functional modulation of these channels remains debated.
Isabella, Tselnicker, Nathan, Dascal
openaire +2 more sources
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]
Science, 2016 Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
Edward C, Twomey +4 more
openaire +2 more sources
BMC Neuroscience, 2003 Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Dolphin Annette C +2 more
doaj +1 more source
The Interaction between Stargazin and PSD-95 Regulates AMPA Receptor Surface Trafficking [PDF]
, 2007 SummaryAccumulation of AMPA receptors at synapses is a fundamental feature of glutamatergic synaptic transmission. Stargazin, a member of the TARP family, is an AMPAR auxiliary subunit allowing interaction of the receptor with scaffold proteins of the ...
Choquet, Daniel +2 more
core +1 more source
Superactivation of AMPA receptors by auxiliary proteins
Nature Communications, 2016 Transmembrane AMPA receptor regulatory proteins (TARPs) exert a number of effects on fast glutamatergic synaptic transmission. Here, the authors model the interactions of two such proteins, Stargazin and γ-8, and propose a simple kinetic mechanism by ...
Anna L. Carbone, Andrew J. R. Plested
doaj +1 more source
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]
Neuron, 2017 AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
Hsin-Wei, Lu +3 more
openaire +2 more sources
Cell Reports, 2014 Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to ...
Shinya Kawata +8 more
doaj +1 more source
Human neuronal stargazin-like proteins, gamma(2), gamma(3) and gamma(4); an investigation of their specific localization in human brain and their influence on Ca(V)2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]
, 2003 Background: Stargazin (gamma(2)) and the closely related gamma(3), and gamma(4) transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) gamma subunits and transmembrane alpha-amino-3 ...
Dolphin, AC, Moss, FJ, Clare, JJ
core
Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors [PDF]
The Journal of Neuroscience, 2010 Subunit assembly governs regulation of AMPA receptor (AMPA-R) synaptic delivery and determines biophysical parameters of the ion channel. However, little is known about the molecular pathways of this process. Here, we present single-particle EM three-dimensional structures of dimeric biosynthetic intermediates of the GluA2 subunit of AMPA-Rs ...
Natalie F, Shanks +4 more
openaire +2 more sources