Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy [PDF]
Science, 2016 Stargazin and the AMPA receptor AMPA-subtype ionotropic glutamate receptors (AMPARs) mediate fast excitatory neurotransmission and contribute to higher cognitive processes such as learning and memory. In the brain, AMPARs exist as protein-protein complexes with various auxiliary subunits that tightly control AMPAR trafficking ...
Edward C, Twomey +4 more
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Molecular characterisation of neurotransmitter receptors in the CNS of the stargazer mutant mouse [PDF]
, 2002 The mutant mouse stargazer shows both ataxia and absence epilepsy from P14 onwards. A PGR amplification strategy was utilised to identify adult (i.e. > 3 months) +/stg from +/+ mice, which share the same phenotype, for use for breeding purposes. The same
Tiwari, Priyanka
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BMC Neuroscience, 2003 Background Stargazin (γ2) and the closely related γ3, and γ4 transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) γ subunits and transmembrane α-amino-3-hydroxy-5-methyl-4 ...
Dolphin Annette C +2 more
doaj +1 more source
Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters [PDF]
Neuron, 2017 AMPARs mediate the briefest synaptic currents in the brain by virtue of their rapid gating kinetics. However, at the mossy fiber-to-unipolar brush cell synapse in the cerebellum, AMPAR-mediated EPSCs last for hundreds of milliseconds, and it has been proposed that this time course reflects slow diffusion from a complex synaptic space. We show that upon
Hsin-Wei, Lu +3 more
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Superactivation of AMPA receptors by auxiliary proteins
Nature Communications, 2016 Transmembrane AMPA receptor regulatory proteins (TARPs) exert a number of effects on fast glutamatergic synaptic transmission. Here, the authors model the interactions of two such proteins, Stargazin and γ-8, and propose a simple kinetic mechanism by ...
Anna L. Carbone, Andrew J. R. Plested
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Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons
European Journal of Pain, Volume 30, Issue 5, May 2026.ABSTRACT Introduction Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment—from the peripheral to central terminals—is key to this effort ...
Julia R. Sondermann +9 more
wiley +1 more source
Cell Reports, 2014 Synapse elimination is crucial for precise neural circuit formation during postnatal development. We examined how relative differences in synaptic strengths among competing inputs and/or absolute synaptic strengths contribute to climbing fiber (CF) to ...
Shinya Kawata +8 more
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Human neuronal stargazin-like proteins, gamma(2), gamma(3) and gamma(4); an investigation of their specific localization in human brain and their influence on Ca(V)2.1 voltage-dependent calcium channels expressed in Xenopus oocytes [PDF]
, 2003 Background: Stargazin (gamma(2)) and the closely related gamma(3), and gamma(4) transmembrane proteins are part of a family of proteins that may act as both neuronal voltage-dependent calcium channel (VDCC) gamma subunits and transmembrane alpha-amino-3 ...
Dolphin, AC, Moss, FJ, Clare, JJ
core
, 2012 (A) Schematic structure of GluA4i, stargazin and GluA4i-stargazin fusion protein. Amino acid sequence of the linkage between the carboxyterminus of GluA4 and the aminoterminus of stargazin is shown below the cartoon. (B) Western blot of GluA4i, stargazin
Tommi Möykkynen (121896) +4 more
core +1 more source
Down-regulation of Stargazin Inhibits the Enhanced Surface Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor GluR1 Subunit in Rat Dorsal Horn and Ameliorates Postoperative Pain [PDF]
, 2014 Stargazin is the first transmembrane protein known to regulate synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors.
Wu, Jing +11 more
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