Epilepsia, Volume 65, Issue 2, Page e20-e26, February 2024.Abstract The transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) regulatory proteins (TARPs), γ2 (stargazin), γ3, γ4, γ5, γ7, and γ8, are a family of proteins that regulate AMPAR trafficking, expression, and biophysical properties that could have a role in the development of absence seizures.
Pablo M. Casillas‐Espinosa +4 more
wiley +1 more source
Postsynaptic protein organization revealed by electron microscopy. [PDF]
, 2019 Neuronal synapses are key devices for transmitting and processing information in the nervous system. Synaptic plasticity, generally regarded as the cellular basis of learning and memory, involves changes of subcellular structures that take place at the ...
Bi, Guo-Qiang +4 more
core
The malleable brain: plasticity of neural circuits and behavior: A review from students to students [PDF]
, 2017 One of the most intriguing features of the brain is its ability to be malleable, allowing it to adapt continually to changes in the environment. Specific neuronal activity patterns drive long-lasting increases or decreases in the strength of synaptic ...
Adeniyi, Philip A. +32 more
core +2 more sources
Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors [PDF]
The Journal of Neuroscience, 2005 The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their synaptic delivery and turnover.
Priel, A. +5 more
openaire +3 more sources
Dual Effects of TARP γ-2 on Glutamate Efficacy Can Account for AMPA Receptor Autoinactivation [PDF]
, 2017 Fast excitatory transmission in the CNS is mediated mainly by AMPA-type glutamate receptors (AMPARs) associated with transmembrane AMPAR regulatory proteins (TARPs).
Coombs, ID +4 more
core +2 more sources
Postsynaptic density 95 controls AMPA receptor incorporation during long-term potentiation and experience-driven synaptic plasticity [PDF]
, 2004 The regulated delivery of AMPA-type glutamate receptors (AMPARs) to synapses is an important mechanism underlying synaptic plasticity. Here, we ask whether the synaptic scaffolding protein PSD-95 (postsynaptic density 95) participates in AMPAR ...
Ehrlich, I., Malinow, R.
core +1 more source
PSD-95-like membrane associated guanylate kinases (PSD-MAGUKs) and synaptic plasticity [PDF]
, 2011 Activity-dependent modification of excitatory synaptic transmission is a fundamental mechanism for developmental plasticity of the neural circuits and experience-dependent plasticity.
Xu, Weifeng
core +1 more source
A study of the molecular basis of the interaction between AMPARs and their auxiliary subunits [PDF]
, 2015 AMPA receptors (AMPARs) are crucial for fast excitatory synaptic transmission throughout the mammalian central nervous system (CNS). At the molecular level, these receptors are tetramers of GluA1-4 subunits, which can be homomeric or heteromeric ...
Krol, KA
core
The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal [PDF]
Journal of Biological Chemistry, 2008 Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties.
Matthew A, Bedoukian +4 more
openaire +2 more sources
LGI proteins in the nervous system [PDF]
, 2013 The development and function of the vertebrate nervous system depend on specific interactions between different cell types. Two examples of such interactions are synaptic transmission and myelination.
Aunin, E. (Eerik) +3 more
core +5 more sources