Results 81 to 90 of about 1,561 (160)

Phosphorylation of the Postsynaptic Density-95 (PSD-95)/Discs Large/Zona Occludens-1 Binding Site of Stargazin Regulates Binding to PSD-95 and Synaptic Targeting of AMPA Receptors

, 2002
Dynamic regulation of AMPA-type receptors at the synapse is proposed to play a critical role in alterations of the synaptic strength seen in cellular models of learning and memory such as long-term potentiation in the hippocampus.
David S. Bredt, Roger A. Nicoll, Lu Chen, Timothy J. Stocker, Dane M. Chetkovich   +4 more
core   +1 more source

The cloning and functional characterisation of a family of human stargazin-like genes [PDF]

, 2002
1) Stargazin, the product of the gene mutated in the epileptic mouse Stargazer, is hypothesised to be the first example of a neuronal voltage-dependent calcium channel (VDCC) γ subunit.
Moss, Fraser John
core   +1 more source

Strukturelle, biochemische und funktionelle Untersuchung von Glutamat- Rezeptoren und des regulatorischen Proteins Stargazin [PDF]

, 2016
CONTENTS ACKNOWLEDGEMENTS V RELATED PUBLICATIONS VII LIST OF FIGURES XI LIST OF TABLES XV LIST OF EQUATIONS XVII ABSTRACT XIX ZUSAMMENFASSUNG XXI 1 INTRODUCTION 1 1.1.1 The glutamate receptor superfamily 1 1.1.2 Modular structure and function of the ...
Chebli, Miriam
core   +1 more source

Different domains of AMPA receptors direct stargazin-mediated trafficking and stargazin-mediated modulation of kinetics

, 2006
Transmembrane AMPA Receptor Regulatory Proteins (TARPs) are the first transmembrane proteins known to associate with AMPA receptors. There are four known TARPs: γ-2, γ-3, γ-4, and γ-8. TARPs are expressed differentially in the brain but there is some overlap. Of these, γ-2, or stargazin is the most extensively studied.
openaire   +2 more sources

Glutamate-induced AMPA receptor desensitization increases their mobility and modulates short-term plasticity through unbinding from stargazin

, 2015
SummaryShort-term plasticity of AMPAR currents during high-frequency stimulation depends not only on presynaptic transmitter release and postsynaptic AMPAR recovery from desensitization, but also on fast AMPAR diffusion.
Françoise Coussen (16223987), Amandine Phillipat (16223999), Eric Hosy (567659), Andrew Penn (4461826), Daniel Choquet (408828), Estelle Toulmé (16223996), Audrey Constals (16223993), Sébastien Marais (16224002), Anne-Sophie Hafner (16223975), Benjamin Compans (12087278), Natacha Retailleau (16223978), Choquet, Daniel, Marais, Sébastien, Hosy, Eric, Constals, Audrey, Retailleau, Natacha, Hafner, Anne-Sophie, Compans, Benjamin, Penn, Andrew C., Coussen, Françoise, Phillipat, Amandine, Toulmé, Estelle   +21 more
core   +1 more source

Lengthening of the stargazin cytoplasmic tail increases synaptic transmission by promoting interaction to deeper domains of PSD-95

, 2015
SummaryPSD-95 is a prominent organizer of the postsynaptic density (PSD) that can present a filamentous orientation perpendicular to the plasma membrane.
Choquet, Daniel, Coussen, F., Poujol, Christel, Philippat, Amandine, Grillo-Bosch, D., Hafner, Anne-Sophie, Sainlos, M., Matthieu Sainlos (1977034), Penn, A., Poujol, C., Patricio Opazo (16223990), Amandine Philippat (16223984), Opazo, Patricio, Natacha Retailleau (16223978), Sainlos, Matthieu, Hafner, A., Christel Poujol (16223981), Retailleau, N., Françoise Coussen (16223987), Andrew Penn (4461826), Daniel Choquet (408828), Grillo-Bosch, Dolors, Philippat, A., Choquet, D., Dolors Grillo-Bosch (2655664), Retailleau, Natacha, Anne-Sophie Hafner (16223975), Opazo, P., Penn, Andrew C., Coussen, Francoise   +29 more
core   +1 more source

Regulation of AMPA receptor function and synaptic localization by stargazin and PSD-95 [PDF]

, 2009
The majority of excitatory transmission in the brain is mediated by glutamatergic synapses. Rapid synaptic signaling is mediated by AMPA and kainate receptors, whereas NMDA receptors mediate slow synaptic currents.
Cokic, Barbara
core   +1 more source

Subunit-dependent differences in stargazin-dependent autoinactivation of AMPA receptors.

, 2012
(A–D) Steady-state concentration-response curves of l-glutamate-triggered current responses of homomeric GluA1i (A), GluA2i (B), GluA3i (C) GluA4i (D) channels coexpressed with stargazin.
Tommi Möykkynen (121896), Esa R. Korpi (121902), Kari Keinänen (121905), Sarah K. Coleman (121899), Artur Semenov (121893)   +4 more
core   +1 more source

Presentation_1_Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses.pdf

, 2018
Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros (5743778), Gladys L. Caldeira (5743781), Ana Luísa Carvalho (372324)   +2 more
core   +1 more source

The role of stargazin deficits in brain disorders

, 2014
Glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are the major mediators of fast excitatory transmission in the mammalian central nervous system (CNS). Regulation of AMPAR trafficking into and out of synapses is important
Shevtsova, Olga
core   +1 more source