Stargazin attenuates intracellular polyamine block of calcium-permeable AMPA receptors [PDF]
Nature Neuroscience, 2007 Endogenous polyamines profoundly affect the activity of various ion channels, including that of calcium-permeable AMPA-type glutamate receptors (CP-AMPARs). Here we show that stargazin, a transmembrane AMPAR regulatory protein (TARP) known to influence transport, gating and desensitization of AMPARs, greatly reduces block of CP-AMPARs by intracellular ...
David, Soto +4 more
openaire +2 more sources
Strukturelle, biochemische und funktionelle Untersuchung von Glutamat- Rezeptoren und des regulatorischen Proteins Stargazin [PDF]
, 2016 CONTENTS ACKNOWLEDGEMENTS V RELATED PUBLICATIONS VII LIST OF FIGURES XI LIST OF TABLES XV LIST OF EQUATIONS XVII ABSTRACT XIX ZUSAMMENFASSUNG XXI 1 INTRODUCTION 1 1.1.1 The glutamate receptor superfamily 1 1.1.2 Modular structure and function of the ...
Chebli, Miriam
core +1 more source
Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]
Proceedings of the National Academy of Sciences, 2006 α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S, Walker +8 more
openaire +2 more sources
Glutamate-Induced AMPA Receptor Desensitization Increases Their Mobility and Modulates Short-Term Plasticity through Unbinding from Stargazin [PDF]
, 2015 SummaryShort-term plasticity of AMPAR currents during high-frequency stimulation depends not only on presynaptic transmitter release and postsynaptic AMPAR recovery from desensitization, but also on fast AMPAR diffusion.
Choquet, Daniel +21 more
core +1 more source
Molecular characterisation of neurotransmitter receptors in the CNS of the stargazer mutant mouse [PDF]
, 2002 The mutant mouse stargazer shows both ataxia and absence epilepsy from P14 onwards. A PGR amplification strategy was utilised to identify adult (i.e. > 3 months) +/stg from +/+ mice, which share the same phenotype, for use for breeding purposes. The same
Tiwari, Priyanka
core
Down-regulation of Stargazin Inhibits the Enhanced Surface Delivery of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate Receptor GluR1 Subunit in Rat Dorsal Horn and Ameliorates Postoperative Pain [PDF]
, 2014 Stargazin is the first transmembrane protein known to regulate synaptic targeting of α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors.
Wu, Jing +11 more
core +1 more source
, 2006 Transmembrane AMPA Receptor Regulatory Proteins (TARPs) are the first transmembrane proteins known to associate with AMPA receptors. There are four known TARPs: γ-2, γ-3, γ-4, and γ-8. TARPs are expressed differentially in the brain but there is some overlap. Of these, γ-2, or stargazin is the most extensively studied.
openaire +2 more sources
, 2002 Dynamic regulation of AMPA-type receptors at the synapse is proposed to play a critical role in alterations of the synaptic strength seen in cellular models of learning and memory such as long-term potentiation in the hippocampus.
David S. Bredt +4 more
core +1 more source
The cloning and functional characterisation of a family of human stargazin-like genes [PDF]
, 2002 1) Stargazin, the product of the gene mutated in the epileptic mouse Stargazer, is hypothesised to be the first example of a neuronal voltage-dependent calcium channel (VDCC) γ subunit.
Moss, Fraser John
core +1 more source
Regulation of AMPA receptor function and synaptic localization by stargazin and PSD-95 [PDF]
, 2009 The majority of excitatory transmission in the brain is mediated by glutamatergic synapses. Rapid synaptic signaling is mediated by AMPA and kainate receptors, whereas NMDA receptors mediate slow synaptic currents.
Cokic, B., Cokic, Barbara
core +1 more source