Results 71 to 80 of about 1,561 (160)

Contribution of the Global Subunit Structure and Stargazin on the Maturation of AMPA Receptors [PDF]

The Journal of Neuroscience, 2010
Subunit assembly governs regulation of AMPA receptor (AMPA-R) synaptic delivery and determines biophysical parameters of the ion channel. However, little is known about the molecular pathways of this process. Here, we present single-particle EM three-dimensional structures of dimeric biosynthetic intermediates of the GluA2 subunit of AMPA-Rs ...
Natalie F, Shanks, Tomohiko, Maruo, Anthony N, Farina, Mark H, Ellisman, Terunaga, Nakagawa   +4 more
openaire   +2 more sources

Stargazin promotes closure of the AMPA receptor ligand-binding domain [PDF]

Journal of General Physiology, 2014
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown.
MacLean, David M., Ramaswamy, Swarna S., Du, Mei, Howe, James R., Jayaraman, Vasanthi   +4 more
openaire   +2 more sources

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

The Journal of Physiology, Volume 603, Issue 20, Page 5935-5964, October 15, 2025.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn, Nils Brose, Benjamin H. Cooper, Elisa D'Este, Michael Fauth, Rubén Fernández‐Busnadiego, Maksims Fiosins, André Fischer, Svilen V. Georgiev, Stefan Jakobs, Stefan Klumpp, Sarah Köster, Felix Lange, Noa Lipstein, Victor Macarrón‐Palacios, Dragomir Milovanovic, Tobias Moser, Marcus Müller, Felipe Opazo, Tiago F. Outeiro, Constantin Pape, Viola Priesemann, Peter Rehling, Tim Salditt, Oliver Schlüter, Nadja Simeth, Claudia Steinem, Tatjana Tchumatchenko, Christian Tetzlaff, Marilyn Tirard, Henning Urlaub, Carolin Wichmann, Fred Wolf, Silvio O. Rizzoli   +35 more
wiley   +1 more source

Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution [PDF]

Nature Neuroscience, 2009
Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in
Helmut W, Kessels, Charles D, Kopec, Matthew E, Klein, Roberto, Malinow   +3 more
openaire   +2 more sources

Phosphorylation‐regulated phase separation of syndecan‐4 and syntenin promotes the biogenesis of exosomes

Cell Proliferation, Volume 57, Issue 10, October 2024.
This research uncovers a novel phosphorylation‐regulated phase separation property of SDC4 on the PM by which SDC4 realizes efficient recruitment of cytosolic syntenin and thereby facilitates the biogenesis of exosomes, providing potential intervention targets for exosome‐involved biomedical events. Abstract The biogenesis of exosomes that mediate cell‐
Tian Zhao, Xiaolan Yang, Guangfei Duan, Jialin Chen, Kefeng He, Yong‐Xiang Chen, Shi‐Zhong Luo   +6 more
wiley   +1 more source

The Stargazin C Terminus Encodes an Intrinsic and Transferable Membrane Sorting Signal [PDF]

Journal of Biological Chemistry, 2008
Activity-dependent plasticity of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors is regulated by their auxiliary subunit, stargazin. Association with stargazin enhances alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor surface expression and modifies the receptor's biophysical properties.
Matthew A, Bedoukian, Jennifer D, Whitesell, Erik J, Peterson, Colin M, Clay, Kathryn M, Partin   +4 more
openaire   +2 more sources

Identification of immune infiltration and PANoptosis‐related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis

Ibrain, Volume 10, Issue 3, Page 323-344, Fall 2024.
Based on R, immune infiltration analysis found that normal and disease immune cells expressed differently, weighted gene co‐expression network analysis determined the key genes of diseases and clustering, and eXtreme Gradient Boosting model screened Hub genes. Abstract This study aims to explore the expression profile of PANoptosis‐related genes (PRGs)
Jin‐Lin Mei, Shi‐Feng Wang, Yang‐Yang Zhao, Ting Xu, Yong Luo, Liu‐Lin Xiong   +5 more
wiley   +1 more source

Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms

Health Science Reports, Volume 7, Issue 2, February 2024.
Abstract Introduction Epilepsy is characterized by having two or more unprovoked seizures. Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular mechanisms. This helps develop diagnostic techniques, treatments, and pharmacotherapy. It also enhances precision medicine and individualized treatment processes.
Sanobar Shariff, Halah A. Nouh, Samuel Inshutiyimana, Charbel Kachouh, Maya M. Abdelwahab, Abubakar Nazir, Magda Wojtara, Olivier Uwishema   +7 more
wiley   +1 more source

Transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor regulatory protein expression during the development of absence seizures in genetic absence epilepsy rats from Strasbourg

Epilepsia, Volume 65, Issue 2, Page e20-e26, February 2024.
Abstract The transmembrane α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor (AMPAR) regulatory proteins (TARPs), γ2 (stargazin), γ3, γ4, γ5, γ7, and γ8, are a family of proteins that regulate AMPAR trafficking, expression, and biophysical properties that could have a role in the development of absence seizures.
Pablo M. Casillas‐Espinosa, Runxuan Lin, Rui Li, Kim L. Powell, Terence J. O'Brien   +4 more
wiley   +1 more source

Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]

Proceedings of the National Academy of Sciences, 2006
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S, Walker, Penelope J, Brockie, David M, Madsen, Michael M, Francis, Yi, Zheng, Sri, Koduri, Jerry E, Mellem, Nathalie, Strutz-Seebohm, Andres V, Maricq   +8 more
openaire   +2 more sources