Results 71 to 80 of about 2,605 (175)

Metabolic etiologies in West syndrome

Epilepsia Open, Volume 3, Issue 2, Page 134-166, June 2018., 2018
Summary West syndrome (WS) is an early life epileptic encephalopathy associated with infantile spasms, interictal electroencephalography (EEG) abnormalities including high amplitude, disorganized background with multifocal epileptic spikes (hypsarrhythmia), and often neurodevelopmental impairments.
Seda Salar, Solomon L. Moshé, Aristea S. Galanopoulou   +2 more
wiley   +1 more source

Stargazin promotes closure of the AMPA receptor ligand-binding domain [PDF]

Journal of General Physiology, 2014
Transmembrane AMPA receptor (AMPAR) regulatory proteins (TARPs) markedly enhance AMPAR function, altering ligand efficacy and receptor gating kinetics and thereby shaping the postsynaptic response. The structural mechanism underlying TARP effects on gating, however, is unknown.
MacLean, David M., Ramaswamy, Swarna S., Du, Mei, Howe, James R., Jayaraman, Vasanthi   +4 more
openaire   +2 more sources

Role for neonatal D-serine signaling: prevention of physiological and behavioral deficits in adult Pick1 knockout mice [PDF]

, 2016
NMDA glutamate receptors play key roles in brain development, function, and dysfunction. Regulatory roles of D-serine in NMDA receptor-mediated synaptic plasticity have been reported.
Jaaro Peled, Hanna, Lewis, Eastman, Nomura, Jun, Núñez Abades, Pedro Antonio   +3 more
core   +1 more source

Phosphorylation‐regulated phase separation of syndecan‐4 and syntenin promotes the biogenesis of exosomes

Cell Proliferation, Volume 57, Issue 10, October 2024.
This research uncovers a novel phosphorylation‐regulated phase separation property of SDC4 on the PM by which SDC4 realizes efficient recruitment of cytosolic syntenin and thereby facilitates the biogenesis of exosomes, providing potential intervention targets for exosome‐involved biomedical events. Abstract The biogenesis of exosomes that mediate cell‐
Tian Zhao, Xiaolan Yang, Guangfei Duan, Jialin Chen, Kefeng He, Yong‐Xiang Chen, Shi‐Zhong Luo   +6 more
wiley   +1 more source

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin [PDF]

Neuron, 2010
The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown. Using single-particle tracking of AMPARs, we show that CaMKII activation and postsynaptic translocation induce the ...
Opazo, Patricio, Labrecque, Simon, Tigaret, Cezar M., Frouin, Arnaud, Wiseman, Paul W., De Koninck, Paul, Choquet, Daniel   +6 more
openaire   +4 more sources

Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function [PDF]

, 2015
UNLABELLED: AMPA-type glutamate receptors are ligand-gated cation channels responsible for a majority of the fast excitatory synaptic transmission in the brain.
Bats, C, Cull-Candy, SG, Farrant, M, McGee, TP   +3 more
core   +2 more sources

Identification of immune infiltration and PANoptosis‐related molecular clusters and predictive model in Alzheimer's disease based on transcriptome analysis

Ibrain, Volume 10, Issue 3, Page 323-344, Fall 2024.
Based on R, immune infiltration analysis found that normal and disease immune cells expressed differently, weighted gene co‐expression network analysis determined the key genes of diseases and clustering, and eXtreme Gradient Boosting model screened Hub genes. Abstract This study aims to explore the expression profile of PANoptosis‐related genes (PRGs)
Jin‐Lin Mei, Shi‐Feng Wang, Yang‐Yang Zhao, Ting Xu, Yong Luo, Liu‐Lin Xiong   +5 more
wiley   +1 more source

S-nitrosation and neuronal plasticity [PDF]

, 2014
Nitric oxide (NO) has long been recognized as a multifaceted participant in brain physiology. Despite the knowledge that was gathered over many years regarding the contribution of NO to neuronal plasticity, for example the ability of the brain to change ...
Alexander, Alexander, Alexander, Alexander, Alsina, Beamer, Bliss, Bossy, Bredt, Böhme, Böhme, Calabrese, Carreira, Carreira, Carreira, Cheng, Cho, Choi, Choquet, Chouchani, Christopherson, Contestabile, Covacu, Dachtler, Dinerman, Estrada, Francis, Fritzen, Gage, Gage, Gallo, García-García, García-López, Garthwaite, Guix, Halloran, Hardingham, Heinrich, Ho, Ho, Hofmann, Huang, Ischiropoulos, Izquierdo-Álvarez, Jawerka, Kakizawa, Kawano, Kim, Lander, Lander, Lee, Lee, Lu, Luo, López-Sánchez, Martínez-Acedo, Martínez-Ruiz, Martínez-Ruiz, Martínez-Ruiz, Martínez-Ruiz, Mieyal, Mizutani, Moreno-López, Moreno-López, Murillo-Carretero, Mustafa, Nadler, Nakamura, Namiki, Nikonenko, Nikonenko, Nott, Nott, O'Dell, O'Dell, Oren, Packer, Park, Pawson, Phelps, Prast, Pérez-Domper, Qu, Reif, Renganathan, Riccio, Robichaux, Roskams, Sabens Liedhegner, Santos, Sattler, Selvakumar, Selvakumar, Selvakumar, Sha, Shelly, Shi, Son, Sossa, Souza, Sun, Sunico, Sunico, Sánchez-Islas, Takahashi, Tegeder, Tegenge, Torroglosa, Whitney, Wu, Zhu, Zhu, Zhuo, Zhuo   +113 more
core   +1 more source

Advances in understanding the pathogenesis of epilepsy: Unraveling the molecular mechanisms

Health Science Reports, Volume 7, Issue 2, February 2024.
Abstract Introduction Epilepsy is characterized by having two or more unprovoked seizures. Understanding the pathogenesis of epilepsy, requires deep investigation into the molecular mechanisms. This helps develop diagnostic techniques, treatments, and pharmacotherapy. It also enhances precision medicine and individualized treatment processes.
Sanobar Shariff, Halah A. Nouh, Samuel Inshutiyimana, Charbel Kachouh, Maya M. Abdelwahab, Abubakar Nazir, Magda Wojtara, Olivier Uwishema   +7 more
wiley   +1 more source

The RNA-binding protein hnRNPA2 regulates β-catenin protein expression and is overexpressed in prostate cancer [PDF]

, 2014
The RNA-binding protein hnRNPA2 (HNRNPA2B1) is upregulated in cancer, where it controls alternative pre-mRNA splicing of cancer-relevant genes. Cytoplasmic hnRNPA2 is reported in aggressive cancers, but is functionally uncharacterized.
Ahmad, Imran, Leung, Hing, Nixon, Colin, Rajan, Prabhakar, Stockley, Jacqueline, Villasevil, M. Eugenia M.   +5 more
core   +1 more source