Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins [PDF]
Proceedings of the National Academy of Sciences, 2006 α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors (AMPARs) are a major subtype of ionotropic glutamate receptors (iGluRs) that mediate rapid excitatory synaptic transmission in the vertebrate brain. Putative AMPARs are also expressed in the nervous system of invertebrates.
Craig S, Walker +8 more
openaire +2 more sources
Glutamat-Rezeptoren und synaptische Plastizität in der lateralen Amygdala [PDF]
, 2019 Synaptische Plastizität an zentralen Synapsen gilt als grundlegender Mechanismus für Lernen und Gedächtnis. Die Amygdala ist für das Furchtgedächtnis von besonderer Bedeutung.
Gebhardt, Christine
core +1 more source
Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. [PDF]
, 2018 Many properties of fast synaptic transmission in the brain are influenced by transmembrane AMPAR regulatory proteins (TARPs) that modulate the pharmacology and gating of AMPA-type glutamate receptors (AMPARs).
Coombs, Ian D. +4 more
core +1 more source
Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors [PDF]
, 2017 Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the role of a reactive cysteine residue, Cys-893, in the cytosolic C-terminal tail of GluA1 AMPA ...
Coleman, S.K. +11 more
core +3 more sources
Glutamate receptor subunit 2 serine 880 phosphorylation modulates synaptic transmission and mediates plasticity in CA1 pyramidal cells [PDF]
, 2003 The cytoplasmic C termini of AMPA receptor subunits contain PDZ ( postsynaptic density 95/Discs large/zona occludens 1) ligand domains that can control their synaptic trafficking during plasticity.
Huganir, R. +3 more
core +1 more source
The C-terminal domain of zDHHC2 contains distinct sorting signals that regulate intracellular localisation in neurons and neuroendocrine cells [PDF]
, 2017 The S-acyltransferase zDHHC2 mediates dynamic S-acylation of PSD95 and AKAP79/150, which impacts synaptic targeting of AMPA receptors. zDHHC2 is responsive to synaptic activity and catalyses the increased S-acylation of PSD95 that occurs following action
Bushell, Trevor J. +4 more
core +1 more source
A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders [PDF]
, 2018 Background: Mutations in the SHANK genes, which encode postsynaptic scaffolding proteins, have been linked to a spectrum of neurodevelopmental disorders. The SHANK genes and the schizophrenia-associated microRNA-137 show convergence on several levels, as
Berkel, Simone +4 more
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Structural and functional roles of KCC2 in developing cortex [PDF]
, 2008 Cation chloride cotransporters (CCCs) are critical for controlling intracellular chloride homeostasis. The CCC family is composed of four isoforms of K-Cl cotransporters (KCC1-4), two isoforms of Na-K-2Cl cotransporters (NKCC1-2), one Na-Cl cotransporter
Li, Hong
core
Synaptic nanomodules underlie the organization and plasticity of spine synapses. [PDF]
, 2018 Experience results in long-lasting changes in dendritic spine size, yet how the molecular architecture of the synapse responds to plasticity remains poorly understood. Here a combined approach of multicolor stimulated emission depletion microscopy (STED)
Dalva, Matthew B. +4 more
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AMPA Receptor Modulation by Stargazin [PDF]
Biophysical Journal, 2017 Sana A. Shaikh +7 more
openaire +1 more source