Results 31 to 40 of about 1,542 (158)

Structural properties and peptide ligand binding of the capsid homology domains of human Arc

Biochemistry and Biophysics Reports, 2021
The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully ...
Erik I. Hallin, Clive R. Bramham, Petri Kursula   +2 more
doaj   +1 more source

A new perspective on hippocampal synaptic plasticity and post‐stroke depression

European Journal of Neuroscience, Volume 58, Issue 4, Page 2961-2984, August 2023., 2023
Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise ...
Ning Sun, Wen‐Qiang Cui, Xiao‐Man Min, Guang‐Ming Zhang, Jia‐Zheng Liu, Hong‐Yun Wu   +5 more
wiley   +1 more source

Slow excitatory synaptic currents generated by AMPA receptors

The Journal of Physiology, Volume 600, Issue 2, Page 217-232, 15 January 2022., 2022
Abstract figure legend Besides their classical fast responses that depress with repeated stimulation (blue), some forms of AMPA‐type glutamate receptors can produce a current with slow kinetics approaching 0.5 s. A progressive increase in the current (‘pedestal’, orange) produces short‐term potentiation from a postsynaptic locus.
Niccolò P. Pampaloni, Andrew J. R. Plested   +1 more
wiley   +1 more source

Role of AMPA receptor desensitization in short term depression – lessons from retinogeniculate synapses

The Journal of Physiology, Volume 600, Issue 2, Page 201-215, 15 January 2022., 2022
Abstract figure legend Retinogeniculate synapses of the dLGN are large synapses with multiple release sites. Pronounced short‐term depression of currents in retinogeniculate synapses results from high release probability and desensitization of AMPA receptors.
Jakob von Engelhardt
wiley   +1 more source

High-affinity anti-Arc nanobodies provide tools for structural and functional studies

PLoS ONE, 2022
Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic plasticity and memory formation in mammals.
Sigurbjörn Markússon, Erik I. Hallin, Helene J. Bustad, Arne Raasakka, Ju Xu, Gopinath Muruganandam, Remy Loris, Aurora Martinez, Clive R. Bramham, Petri Kursula   +9 more
doaj   +3 more sources

Targeted sensors for glutamatergic neurotransmission

eLife, 2023
Optical report of neurotransmitter release allows visualisation of excitatory synaptic transmission. Sensitive genetically-encoded fluorescent glutamate reporters operating with a range of affinities and emission wavelengths are available.
Yuchen Hao, Estelle Toulmé, Benjamin König, Christian Rosenmund, Andrew JR Plested   +4 more
doaj   +1 more source

HDACi protects against vascular cognitive impairment from CCH injury via induction of BDNF‐related AMPA receptor activation

Journal of Cellular and Molecular Medicine, Volume 25, Issue 15, Page 7418-7425, August 2021., 2021
Abstract We previously showed a hydroxamic acid‐based histone deacetylase inhibitor (HDACi), compound 13, provides neuroprotection against chronic cerebral hypoperfusion (CCH) both in vitro under oxygen‐glucose deprivation (OGD) conditions and in vivo under bilateral common carotid artery occlusion (BCCAO) conditions.
Yao‐Ching Fang, Jia‐Yu Hsieh, Amelia Nur Vidyanti, Chih‐Hao Yang, Jing‐Shiun Jan, Kang‐Wei Chang, Chaur‐Jong Hu, Yong‐Kwang Tu   +7 more
wiley   +1 more source

Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

iScience, 2022
Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen, Christian Parsbæk Pedersen, Vita Sereikaite, Jannik Nedergaard Pedersen, Maria Vistrup-Parry, Andreas Toft Sørensen, Daniel Otzen, Kaare Teilum, Kenneth Lindegaard Madsen, Kristian Strømgaard   +9 more
doaj   +1 more source

Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]

Biophysical Journal, 2014
AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Carbone, Anna L., Plested, Andrew J.
openaire   +1 more source

Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease

The Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021
Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley   +1 more source