Results 31 to 40 of about 2,605 (175)

Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

iScience, 2022
Summary: The organization of the postsynaptic density (PSD), a protein-dense semi-membraneless organelle, is mediated by numerous specific protein–protein interactions (PPIs) which constitute a functional postsynapse.
Nikolaj Riis Christensen, Christian Parsbæk Pedersen, Vita Sereikaite, Jannik Nedergaard Pedersen, Maria Vistrup-Parry, Andreas Toft Sørensen, Daniel Otzen, Kaare Teilum, Kenneth Lindegaard Madsen, Kristian Strømgaard   +9 more
doaj   +1 more source

Ca2+‐permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease

The Journal of Physiology, Volume 599, Issue 10, Page 2655-2671, 15 May 2021., 2021
Abstract figure legend AMPARs containing GluA2 (red subunits) are Ca2+‐impermeable (CI‐AMPARs). Those that lack GluA2 are Ca2+‐permeable (CP‐AMPARs) and are implicated in diverse forms of synaptic plasticity and disease. Both native CP‐ and CI‐AMPARs contain various auxiliary subunits (shown as yellow, green or turquoise) that affect AMPAR function and
Stuart G. Cull‐Candy, Mark Farrant
wiley   +1 more source

Functional genomic analyses highlight a shift in Gpr17‐regulated cellular processes in oligodendrocyte progenitor cells and underlying myelin dysregulation in the aged mouse cerebrum

Aging Cell, Volume 20, Issue 4, April 2021., 2021
Ageing reduces the number of OPCs and their ‘stemness’. Genomic analysis resolved key mechanisms underpinning the age related decline in OPCs, most notably reduced expression of Gpr17 in a subpopulation of differentiation committed OPCs. Pharmacogenomics identified small molecules that have the potential to rejuvenate OPCs and promote myelination and ...
Andrea D. Rivera, Francesca Pieropan, Irene Chacon‐De‐La‐Rocha, Davide Lecca, Maria P. Abbracchio, Kasum Azim, Arthur M. Butt   +6 more
wiley   +1 more source

Stargazin controls the pharmacology of AMPA receptor potentiators [PDF]

Proceedings of the National Academy of Sciences, 2006
Glutamate is the major excitatory neurotransmitter in brain, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) mediate the majority of postsynaptic depolarization. AMPAR ion channels display rapid gating, and their deactivation and desensitization determine the timing of synaptic transmission.
Susumu, Tomita, Masayuki, Sekiguchi, Keiji, Wada, Roger A, Nicoll, David S, Bredt   +4 more
openaire   +2 more sources

mRNA Trafficking in the Nervous System: A Key Mechanism of the Involvement of Activity‐Regulated Cytoskeleton‐Associated Protein (Arc) in Synaptic Plasticity

Neural Plasticity, Volume 2021, Issue 1, 2021., 2021
Synaptic activity mediates information storage and memory consolidation in the brain and requires a fast de novo synthesis of mRNAs in the nucleus and proteins in synapses. Intracellular localization of a protein can be achieved by mRNA trafficking and localized translation. Activity‐regulated cytoskeleton‐associated protein (Arc) is a master regulator
Michal Fila, Laura Diaz, Joanna Szczepanska, Elzbieta Pawlowska, Janusz Blasiak, Diano Marrone   +5 more
wiley   +1 more source

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders [PDF]

, 2019
AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders ...
al., et, Constantino, John N., Fassi, Emily, Shinawi, Marwan   +3 more
core   +24 more sources

Screening for AMPA receptor auxiliary subunit specific modulators. [PDF]

PLoS ONE, 2017
AMPA receptors (AMPAR) are ligand gated ion channels critical for synaptic transmission and plasticity. Their dysfunction is implicated in a variety of psychiatric and neurological diseases ranging from major depressive disorder to amyotrophic lateral ...
Caleigh M Azumaya, Emily L Days, Paige N Vinson, Shaun Stauffer, Gary Sulikowski, C David Weaver, Terunaga Nakagawa   +6 more
doaj   +1 more source

Synaptic AMPA receptor composition in development, plasticity and disease [PDF]

, 2016
AMPA receptors (AMPARs) are assemblies of four core subunits, GluA1–4, that mediate most fast excitatory neurotransmission. The component subunits determine the functional properties of AMPARs, and the prevailing view is that the subunit composition also
A Citri, A Constals, A Goel, A Goel, A Nishimune, A Semenov, A Sumioka, A Terashima, A Wright, AC Jackson, AC Jackson, AJ Granger, AJ Granger, AJ Granger, AL Mammen, AS Kristensen, B Sommer, BE Herring, C Bats, C Bats, C Bellone, C Bellone, C Bokel, CH Kim, CY Tai, D Mauceri, D Nair, D Soto, D Soto, D Studniarczyk, D Zamanillo, DA Fortin, DE Pellegrini-Giampietro, DJ Whitcomb, DM Walsh, DT Lin, E Kalashnikova, E Sauvageau, E Schnell, E Suzuki, EE Gray, EM Petrini, ES Guire, F Ogoshi, GG Turrigiano, GH Diering, GJ Soler-Llavina, GM Shankar, H Adesnik, H Dong, H Hampel, H Makino, H Monyer, H Wu, HD MacGillavry, HK Lee, HK Lee, HK Lee, HW Kessels, HY Man, ID Coombs, IH Greger, IH Greger, IH Greger, IH Greger, J Aoto, J Boehm, J Schwenk, J von Engelhardt, JA Esteban, JD Shepherd, Jeremy M. Henley, JG Hanley, JJ Zhu, JL Sanderson, JM Henley, JM Henley, JM Kerr, JM Spaethling, JP Steinberg, JQ Wang, JR Brorson, JT Isaac, K Archibald, K He, K Plant, KA Pelkey, Kevin A. Wilkinson, KL Conrad, KW Roche, L Chen, L Kelly, L Pickard, L Saglietti, L Volk, LS Loo, M Carta, M Morimoto-Tomita, M Rossmann, M Sheng, M Sukumaran, MA Gainey, MA Sutton, MG Blair, ML Mayer, MS Washburn, MT Ho, MW Linhoff, N Harmel, N Jaafari, N Sans, NF Shanks, NJ Allen, NK Hussain, NV Luchkina, P Farrow, P Opazo, P Opazo, P Steiner, PJ Brockie, RA Nicoll, RJ Wenthold, RL Clem, RL Clem, RL Huganir, S Cull-Candy, S Hestrin, S Kim, S Shi, S Tomita, S Tomita, S Tomita, SC Haering, SH Lee, SJ Liu, SJ Liu, SJ Mah, SM Gardner, SQ Liu, SS Kumar, SY Grooms, T Hosokawa, T Nakagawa, T Nakagawa, T Yamashita, TA Verdoorn, TC Thiagarajan, TE Chater, TG Banke, V Bernard, W Lu, W Lu, W Lu, W Vandenberghe, W Wisden, WQ Zhao, Y Hayashi, Y Kawahara, Y Yang, Y Zheng   +159 more
core   +3 more sources

Mechanism of Modulation of AMPA Receptors by Stargazin [PDF]

Biophysical Journal, 2014
AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in the brain. Native AMPARs typically form heterotetrameric complexes and associate with a variety of auxiliary subunits. Stargazin (gamma2) is the prototype and most studied member of the transmembrane AMPA receptor regulatory proteins family, and regulates several ...
Carbone, Anna L., Plested, Andrew J.
openaire   +1 more source

Glutamatergic neurons induce expression of functional glutamatergic synapses in primary myotubes. [PDF]

, 2012
The functioning of the nervous system depends upon the specificity of its synaptic contacts. The mechanisms triggering the expression of the appropriate receptors on postsynaptic membrane and the role of the presynaptic partner in the differentiation of ...
Baiguera C, Benarese M, Branca C, Buffelli M, Ettorre M, Laperchia C, Lorenzetto E, Pizzi M, Spano P   +8 more
core   +1 more source