Results 31 to 40 of about 1,561 (160)

Compensatory Interplay Between Clarin-1 and Clarin-2 Deafness-Associated Proteins Governs Phenotypic Variability in Hearing. [PDF]

Adv Sci (Weinh)
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Wentling M, Yakhlef Sanchez A, Thelen N, Senarisoy M, Hogg M, Condamine S, Lelli A, Wysocka E, Patni P, Vitry S, Yildizhan KY, Le Gal S, Nouaille S, Bowl MR, Thiry M, Dulon D, Delmaghani S, El-Amraoui A.   +17 more
europepmc   +2 more sources

Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation

iScience, 2021
Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains.
Maria Vistrup-Parry, Xudong Chen, Thea L. Johansen, Sofie Bach, Sara C. Buch-Larsen, Christian R.O. Bartling, Chenxue Ma, Louise S. Clemmensen, Michael L. Nielsen, Mingjie Zhang, Kristian Strømgaard   +10 more
doaj   +1 more source

Stargazin is an AMPA receptor auxiliary subunit [PDF]

Proceedings of the National Academy of Sciences, 2005
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim, Vandenberghe, Roger A, Nicoll, David S, Bredt   +2 more
openaire   +2 more sources

Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease

Molecular Medicine, 2021
Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease.
Xunhu Gu, Hanjun Wu, Yuqin Xie, Lijun Xu, Xu Liu, Wei Wang   +5 more
doaj   +1 more source

Phenotypic heterogeneity in the stargazin allelic series [PDF]

Mammalian Genome, 2003
The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A, Kang, M G, Mahaffey, C L, Beyer, B, Tenbrink, H, Campbell, K P, Frankel, W N   +6 more
openaire   +3 more sources

A mild impairment in reversal learning in a bowl‐digging substrate deterministic task but not other cognitive tests in the Dlg2+/− rat model of genetic risk for psychiatric disorder

Genes, Brain and Behavior, Volume 22, Issue 6, December 2023., 2023
Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+/‐ rat model. Dlg2+/‐ rats exhibited a mild impairment in reversal learning but only in a substrate deterministic bowl‐digging reversal learning task.
Simonas Griesius, Sophie Waldron, Katie A. Kamenish, Nick Cherbanich, Lawrence S. Wilkinson, Kerrie L. Thomas, Jeremy Hall, Jack R. Mellor, Dominic M. Dwyer, Emma S. J. Robinson   +9 more
wiley   +1 more source

Different Domains of the AMPA Receptor Direct Stargazin-mediated Trafficking and Stargazin-mediated Modulation of Kinetics [PDF]

Journal of Biological Chemistry, 2006
Stargazin is an accessory protein of AMPA receptors that enhances surface expression and also affects the biophysical properties of the receptor. AMPA receptor domains necessary for either of these two processes have not yet been identified. Here, we used confocal imaging and electrophysiology of heterologously expressed, fluorophore-tagged GluR1 ...
Matthew A, Bedoukian, Autumn M, Weeks, Kathryn M, Partin   +2 more
openaire   +2 more sources

Structural properties and peptide ligand binding of the capsid homology domains of human Arc

Biochemistry and Biophysics Reports, 2021
The activity-regulated cytoskeleton-associated protein (Arc) is important for synaptic plasticity and the normal function of the brain. Arc interacts with neuronal postsynaptic proteins, but the mechanistic details of its function have not been fully ...
Erik I. Hallin, Clive R. Bramham, Petri Kursula   +2 more
doaj   +1 more source

A new perspective on hippocampal synaptic plasticity and post‐stroke depression

European Journal of Neuroscience, Volume 58, Issue 4, Page 2961-2984, August 2023., 2023
Abstract Post‐stroke depression, a common complication after stroke, severely affects the recovery and quality of life of patients with stroke. Owing to its complex mechanisms, post‐stroke depression treatment remains highly challenging. Hippocampal synaptic plasticity is one of the key factors leading to post‐stroke depression; however, the precise ...
Ning Sun, Wen‐Qiang Cui, Xiao‐Man Min, Guang‐Ming Zhang, Jia‐Zheng Liu, Hong‐Yun Wu   +5 more
wiley   +1 more source

Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity

Acta Physiologica, Volume 236, Issue 3, November 2022., 2022
Abstract The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a protein interaction hub and dynamic regulator of intra‐cellular signaling in synaptic plasticity.
Maria Steene Eriksen, Clive R. Bramham
wiley   +1 more source