Phosphorylation of Stargazin by Protein Kinase A Regulates Its Interaction with PSD-95 [PDF]
Journal of Biological Chemistry, 2002 Stargazin is the first transmembrane protein known to associate with AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) glutamate receptors (AMPARs) and regulate their synaptic targeting by two distinct mechanisms, specifically via delivery of AMPARs to the surface membrane and synaptic targeting of these receptors by binding to PSD-95/SAP-90 ...
Eunjoon Kim, Jaewon Ko, Jae-Ran Lee
exaly +5 more sources
Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
doaj +4 more sources
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability [PDF]
Mol Psychiatry, 2022 Mutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse.
Rondão, T. +15 more
core +2 more sources
Bidirectional Synaptic Plasticity Regulated by Phosphorylation of Stargazin-like TARPs [PDF]
Neuron, 2005 Synaptic plasticity involves protein phosphorylation cascades that alter the density of AMPA-type glutamate receptors at excitatory synapses; however, the crucial phosphorylated substrates remain uncertain. Here, we show that the AMPA receptor-associated protein stargazin is quantitatively phosphorylated and that stargazin phosphorylation promotes ...
Tomita, Susumu +4 more
openaire +4 more sources
Differences in Src phosphorylation of PSD‐93 and PSD‐95 drive differences in scaffolding activity [PDF]
Protein Science, Volume 35, Issue 2, February 2026.Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Frank A. Mindlin +3 more
wiley +2 more sources
The tetraspanin TSPAN5 regulates AMPAR exocytosis by interacting with the AP4 complex [PDF]
eLife, 2023 Intracellular trafficking of AMPA receptors is a tightly regulated process which involves several adaptor proteins, and is crucial for the activity of excitatory synapses both in basal conditions and during synaptic plasticity.
Edoardo Moretto +7 more
doaj +2 more sources
Molecular cloning of the gene promoter encoding the human CaVγ2/Stargazin divergent transcript (CACNG2-DT): characterization and regulation by the cAMP-PKA/CREB signaling pathway [PDF]
Frontiers in Physiology, 2023 CaVγ2 (Stargazin or TARPγ2) is a protein expressed in various types of neurons whose function was initially associated with a decrease in the functional expression of voltage-gated presynaptic Ca2+ channels (CaV) and which is now known to promote the ...
David Muñoz-Herrera +9 more
doaj +2 more sources
Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling [PDF]
Frontiers in Molecular Neuroscience, 2023 The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-
Martino Avallone +13 more
doaj +2 more sources
Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections [PDF]
Hippocampus, Volume 35, Issue 6, November 2025.ABSTRACT This essay describes the development of the in vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was on field potential studies of synaptic plasticity, including LTP, in the rat in vitro hippocampal slice.
Bradley E. Alger
wiley +2 more sources
Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity [PDF]
Acta Physiologica, Volume 236, Issue 3, November 2022., 2022 Abstract The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a protein interaction hub and dynamic regulator of intra‐cellular signaling in synaptic plasticity.
Maria Steene Eriksen, Clive R. Bramham
wiley +2 more sources