Results 11 to 20 of about 2,605 (175)

Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses [PDF]

Frontiers in Molecular Neuroscience, 2018
Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Gladys L Caldeira, Arselio P Carvalho
exaly   +6 more sources

A Role for Stargazin in Experience-Dependent Plasticity

Cell Reports, 2014
During development, neurons are constantly refining their connections in response to changes in activity. Experience-dependent plasticity is a key form of synaptic plasticity, involving changes in α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ...
Susana R. Louros, Bryan M. Hooks, Liza Litvina, Ana Luisa Carvalho, Chinfei Chen   +4 more
doaj   +4 more sources

Stargazin and AMPA receptor membrane expression is increased in the somatosensory cortex of Genetic Absence Epilepsy Rats from Strasbourg

Neurobiology of Disease, 2011
Absence-like seizures in the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model are believed to arise in hyperexcitable somatosensory cortical neurons, however the cellular basis of this increased excitability remains unknown. We have previously
Rahul D Barmanray, Christopher A Reid, Kim L Powell   +2 more
exaly   +3 more sources

Differences in Src phosphorylation of PSD-93 and PSD-95 drive differences in scaffolding activity. [PDF]

Protein Sci
Abstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Mindlin FA, Sasazawa M, Byrnes J, Bowen ME.   +3 more
europepmc   +2 more sources

Notes on the History of In Vitro Hippocampal Electrophysiology and LTP: Personal Reflections. [PDF]

Hippocampus
ABSTRACT This essay describes the development of the in vitro hippocampal slice technique and my small contributions to it and to influencing Roger Nicoll's early interests in the hippocampus and LTP. My Ph.D. work at Harvard with Timothy Teyler was on field potential studies of synaptic plasticity, including LTP, in the rat in vitro hippocampal slice.
Alger BE.
europepmc   +2 more sources

Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity. [PDF]

Acta Physiol (Oxf), 2022
Abstract The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work? Inside the neuron, Arc is a protein interaction hub and dynamic regulator of intra‐cellular signaling in synaptic plasticity.
Eriksen MS, Bramham CR.
europepmc   +2 more sources

Compensatory Interplay Between Clarin-1 and Clarin-2 Deafness-Associated Proteins Governs Phenotypic Variability in Hearing. [PDF]

Adv Sci (Weinh)
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Wentling M, Yakhlef Sanchez A, Thelen N, Senarisoy M, Hogg M, Condamine S, Lelli A, Wysocka E, Patni P, Vitry S, Yildizhan KY, Le Gal S, Nouaille S, Bowl MR, Thiry M, Dulon D, Delmaghani S, El-Amraoui A.   +17 more
europepmc   +2 more sources

Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation

iScience, 2021
Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains.
Maria Vistrup-Parry, Xudong Chen, Thea L. Johansen, Sofie Bach, Sara C. Buch-Larsen, Christian R.O. Bartling, Chenxue Ma, Louise S. Clemmensen, Michael L. Nielsen, Mingjie Zhang, Kristian Strømgaard   +10 more
doaj   +1 more source

Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]

PLoS ONE, 2012
Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov, Tommi Möykkynen, Sarah K Coleman, Esa R Korpi, Kari Keinänen   +4 more
doaj   +1 more source

Stargazin is an AMPA receptor auxiliary subunit [PDF]

Proceedings of the National Academy of Sciences, 2005
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim, Vandenberghe, Roger A, Nicoll, David S, Bredt   +2 more
openaire   +2 more sources