Results 21 to 30 of about 1,542 (158)

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing [PDF]

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +2 more sources

Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors [PDF]

The Journal of Neuroscience, 2005
The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their synaptic delivery and turnover.
Priel, A., Kolleker, A., Ayalon, G., Gillor, M., Osten, P., Stern-Bach, Y.   +5 more
openaire   +4 more sources

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin [PDF]

Neuron, 2010
The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown. Using single-particle tracking of AMPARs, we show that CaMKII activation and postsynaptic translocation induce the ...
Opazo, Patricio, Labrecque, Simon, Tigaret, Cezar M., Frouin, Arnaud, Wiseman, Paul W., De Koninck, Paul, Choquet, Daniel   +6 more
openaire   +6 more sources

Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution [PDF]

Nature Neuroscience, 2009
Understanding how the subcellular fate of newly synthesized AMPA receptors (AMPARs) is controlled is important for elucidating the mechanisms of neuronal function. We examined the effect of increased synthesis of AMPAR subunits on their subcellular distribution in rat hippocampal neurons. Virally expressed AMPAR subunits (GluR1 or GluR2) accumulated in
Helmut W, Kessels, Charles D, Kopec, Matthew E, Klein, Roberto, Malinow   +3 more
openaire   +3 more sources

Interactome of stargazin: relevance in neuropsychiatric disorders

, 2016
Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra.
Rodrigues, Marina Manuela Ventura
openaire   +2 more sources

Site-specific phosphorylation of PSD-95 dynamically regulates the postsynaptic density as observed by phase separation

iScience, 2021
Summary: Postsynaptic density protein 95 is a key scaffolding protein in the postsynaptic density of excitatory glutamatergic neurons, organizing signaling complexes primarily via its three PSD-95/Discs-large/Zona occludens domains.
Maria Vistrup-Parry, Xudong Chen, Thea L. Johansen, Sofie Bach, Sara C. Buch-Larsen, Christian R.O. Bartling, Chenxue Ma, Louise S. Clemmensen, Michael L. Nielsen, Mingjie Zhang, Kristian Strømgaard   +10 more
doaj   +1 more source

Caspase-1/IL-1β represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer’s disease

Molecular Medicine, 2021
Background Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease.
Xunhu Gu, Hanjun Wu, Yuqin Xie, Lijun Xu, Xu Liu, Wei Wang   +5 more
doaj   +1 more source

Stargazin is an AMPA receptor auxiliary subunit [PDF]

Proceedings of the National Academy of Sciences, 2005
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors mediate fast excitatory synaptic transmission in brain and underlie aspects of synaptic plasticity. Numerous AMPA receptor-binding proteins have been implicated in AMPA receptor trafficking and anchoring.
Wim, Vandenberghe, Roger A, Nicoll, David S, Bredt   +2 more
openaire   +2 more sources

Phenotypic heterogeneity in the stargazin allelic series [PDF]

Mammalian Genome, 2003
The stargazer mutant mouse is characterized by its ataxic gait, head tossing, and absence seizures. The mutation was identified in the gamma 2 subunit gene of the high voltage-dependent calcium channel, Cacng2. Subsequently, two allelic variants of stargazer have arisen, waggler and stargazer 3J. In this study, we have compared these new alleles to the
Letts, V A, Kang, M G, Mahaffey, C L, Beyer, B, Tenbrink, H, Campbell, K P, Frankel, W N   +6 more
openaire   +3 more sources

A mild impairment in reversal learning in a bowl‐digging substrate deterministic task but not other cognitive tests in the Dlg2+/− rat model of genetic risk for psychiatric disorder

Genes, Brain and Behavior, Volume 22, Issue 6, December 2023., 2023
Variations in the Dlg2 gene have been linked to increased risk for psychiatric disorders. Here, we tested these predicted effects with a behavioural characterisation of the heterozygous Dlg2+/‐ rat model. Dlg2+/‐ rats exhibited a mild impairment in reversal learning but only in a substrate deterministic bowl‐digging reversal learning task.
Simonas Griesius, Sophie Waldron, Katie A. Kamenish, Nick Cherbanich, Lawrence S. Wilkinson, Kerrie L. Thomas, Jeremy Hall, Jack R. Mellor, Dominic M. Dwyer, Emma S. J. Robinson   +9 more
wiley   +1 more source