Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling [PDF]
Frontiers in Molecular Neuroscience, 2023 The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants of a structural GAG retrotransposon sequence, produces a protein that self-assembles into capsid-
Martino Avallone +13 more
doaj +2 more sources
Learning from stargazin: the mouse, the phenotype and the unexpected
Current Opinion in Neurobiology, 2006 The stargazin gene (also referred to as Cacng2) has been identified by forward genetics in a spontaneous mouse mutant with ataxic gait, upward head-elevating movements (hence the name stargazer for the mouse) and episodes of spike-wave discharges ...
Stern-Bach, Y. +3 more
core +4 more sources
Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95 [PDF]
Journal of Biological Chemistry, 2002 Stargazin is the first transmembrane protein known to associate with AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate) glutamate receptors (AMPARs) and regulate their synaptic targeting by two distinct mechanisms, specifically via delivery of ...
Choi, J +6 more
core +4 more sources
Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors [PDF]
The Journal of Neuroscience, 2005 The AMPA-type glutamate receptors mediate the majority of the fast excitatory synaptic transmission and critically contribute to synaptic plasticity in the brain, hence the existence of numerous trafficking proteins dedicated to regulation of their ...
Stern-Bach, Y. +11 more
core +4 more sources
Stargazin involvement with bipolar disorder and response to lithium treatment
Pharmacogenetics and Genomics, 2008 Objectives Multiple reports have implicated chromosomal region 22q13.1 in both schizophrenia and bipolar disorder. The calcium channel gamma-2 subunit gene (cacng2, Stargazin) located on 22q13.1 was recently reported to be associated with schizophrenia ...
Munro, J +9 more
core +4 more sources
CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin [PDF]
Neuron, 2010 SummaryThe Ca2+/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown.
Tigaret, Cezar M. +13 more
core +5 more sources
Interactome of stargazin: relevance in neuropsychiatric disorders
, 2016 RODRIGUES. Marina Manuela Ventura - Interactome of stargazin: relevance in neuropsychiatric disorders. Coimbra : [s.n.], 2016.
Rodrigues, Marina Manuela Ventura
core +2 more sources
Differences in Src phosphorylation of PSD-93 and PSD-95 drive differences in scaffolding activity. [PDF]
Protein SciAbstract Scaffold proteins contain multiple binding modules that allow for co‐localization of proteins that lack a direct interaction. Evolution resulted in different combinations of binding modules that rewired existing signal transduction pathways.
Mindlin FA +3 more
europepmc +2 more sources
Inhibition of AMPA Receptors by Polyamine Toxins is Regulated by Agonist Efficacy and Stargazin
Neurochemical Research, 2014 The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) are glutamate-gated cation channels mediating the majority of fast excitatory synaptic transmission in the central nervous system (CNS).
Strømgaard, Kristian +3 more
core +4 more sources
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability. [PDF]
Mol Psychiatry, 2022 Mutations linked to neurodevelopmental disorders, such as intellectual disability (ID), are frequently found in genes that encode for proteins of the excitatory synapse.
Caldeira GL +14 more
europepmc +2 more sources