Results 11 to 20 of about 50,502 (231)
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh +7 more
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AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]
Cellular and Molecular Life Sciences, 2019 To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated. In glutamatergic neurons, synaptic strength is controlled by the number and function of AMPA receptors at the ...
Diane Bissen +2 more
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AMPA receptor subunit expression in the endoplasmic reticulum in frontal cortex of elderly patients with schizophrenia. [PDF]
PLoS ONE, 2012 Several lines of evidence indicate altered trafficking of α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors in schizophrenia. Previous reports have shown potential changes in the trafficking of AMPA receptors based on subunit expression
John C Hammond +3 more
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Regulation of AMPA receptors in spinal nociception
Molecular Pain, 2010 The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studied in vitro and in vivo. The AMPA receptors present a unique characteristic
Lin Qing +5 more
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Regulation of AMPA Receptors by Phosphorylation [PDF]
Neurochemical Research, 2000 The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions.
Carvalho, Ana Luísa +2 more
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Evolutionarily conserved pattern of AMPA receptor subunit glycosylation in Mammalian frontal cortex. [PDF]
PLoS ONE, 2014 Protein glycosylation may contribute to the evolution of mammalian brain complexity by adapting excitatory neurotransmission in response to environmental and social cues.
Janusz Tucholski +3 more
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Testing of the therapeutic efficacy and safety of AMPA receptor RNA aptamers in an ALS mouse model
Life Science Alliance, 2022 RNA aptamers designed to block AMPA receptors effectively reduce progression of motor dysfunction, improve TDP-43 pathology, and prevent death of motor neurons in AR2 mice, a mouse model of sporadic ALS, without adverse effects.
Megumi Akamatsu +7 more
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Gating Modes in AMPA Receptors [PDF]
The Journal of Neuroscience, 2010 AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and
Martin Loynaz, Prieto +1 more
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Stargazin Dephosphorylation Mediates Homeostatic Synaptic Downscaling of Excitatory Synapses
Frontiers in Molecular Neuroscience, 2018 Synaptic scaling is a form of homeostatic plasticity that is critical for maintaining neuronal activity within a dynamic range, and which alters synaptic strength through changes in postsynaptic AMPA-type glutamate receptors.
Susana R. Louros +3 more
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AMPA receptor trafficking and learning [PDF]
European Journal of Neuroscience, 2010 AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
J, Keifer, Z, Zheng
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