Results 51 to 60 of about 2,334,241 (398)
Amyloid-β effects on synapses and memory require AMPA receptor subunit GluA3
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance In Alzheimer’s disease, soluble clusters of amyloid-β (Aβ) are believed to degrade synapses and impair memory formation. The removal of AMPA receptors from synapses was previously shown to be a critical step in Aβ-driven synapse loss.
N. Reinders +6 more
semanticscholar +1 more source
Dissecting the Activation of AMPA Receptors [PDF]
Biophysical Journal, 2013 Ionotropic glutamate receptors are tetrameric ion channels that are activated by the neurotransmitter glutamate at excitatory synapses. It is known that after the binding of glutamate, the AMPA-subtype of glutamate receptors transits through distinct functional states to become fully activated, however, the conformations sampled by the tetramer during ...
Andrew J.R. Plested +6 more
openaire +2 more sources
Neurodegeneration in multiple sclerosis
WIREs Mechanisms of Disease, Volume 15, Issue 1, January/February 2023., 2023 Chronic demyelination results in impaired axon metabolism and function, ultimately leading to progressive neurological decline. Neuroprotective strategies aim to protect axons from inflammatory‐mediated destruction, thereby improving axonal integrity and clinical disability (Image created in BioRender.com).
Gabrielle M. Mey +2 more
wiley +1 more source
Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins [PDF]
, 2003 Functional expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in cerebellar granule cells requires stargazin, a member of a large family of four-pass transmembrane proteins.
Bredt, David S. +6 more
core +2 more sources
AMPA Receptor Activation [PDF]
Neuron, 2004 AMPA receptors are tetramers assembled as a dimer-of-dimers with a 2-fold rotational symmetry in their extracellular domains. Two papers in this issue of Neuron, by Horning and Mayer and Sobolevsky et al., provide complementary data that extend this view and highlight the role of dimers in channel gating.
openaire +3 more sources
Cell Reports, 2017 Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity.
Sylvia Pfennig +6 more
doaj +1 more source
AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval
Frontiers in Human Neuroscience, 2021 Retrieval constitutes a highly regulated and dynamic phase in memory processing. Its rapid temporal scales require a coordinated molecular chain of events at the synaptic level that support transient memory trace reactivation.
Magdalena Pereyra +3 more
doaj +1 more source
Revising Berg-Purcell for finite receptor kinetics [PDF]
, 2021 From nutrient uptake, to chemoreception, to synaptic transmission, many systems in cell biology depend on molecules diffusing and binding to membrane receptors. Mathematical analysis of such systems often neglects the fact that receptors process molecules at finite kinetic rates.
arxiv +1 more source
Selective disruption of stimulus-reward learning in glutamate receptor gria 1 knockout mice. [PDF]
, 2003 Glutamatergic neurotransmission via AMPA receptors has been an important focus of studies investigating neuronal plasticity. AMPA receptor glutamate receptor 1 (GluR1) subunits play a critical role in long-term potentiation (LTP).
Mead, Andy N, Stephens, David N
core +2 more sources
AMPA receptor biogenesis and trafficking
Current Opinion in Neurobiology, 2007 AMPA-type glutamate receptors mediate the majority of fast excitatory transmission in the central nervous system. The trafficking of AMPA receptors to and from synapses alters synaptic strength and has been recognized as a central mechanism underlying various forms of synaptic plasticity.
José A. Esteban, Ingo H. Greger
openaire +4 more sources