Results 81 to 90 of about 2,334,241 (398)
Epilepsia, Volume 63, Issue 12, Page e156-e163, December 2022., 2022 Abstract α‐Amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid‐type glutamate receptors (AMPARs) are ligand‐gated cationic channels formed from combinations of GluA1‐4 subunits. Pathogenic variants of GRIA1–4 have been described in patients with developmental delay, intellectual disability, autism spectrum disorder, and seizures, with GRIA2 variants ...
Ian D. Coombs +5 more
wiley +1 more source
Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo
Nature Neuroscience, 2015 Regulation of AMPA receptor (AMPAR) membrane trafficking is critical for synaptic plasticity, as well as for learning and memory. However, the mechanisms of AMPAR trafficking in vivo remain elusive.
Yong Zhang +4 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier +26 more
wiley +1 more source
Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation. [PDF]
PLoS ONE, 2012 Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane accessory proteins.
Artur Semenov +4 more
doaj +1 more source
Estimating the synaptic current in a multi-conductance AMPA receptor model [PDF]
, 2010 A pre-synaptic neuron releases diffusing neurotransmitters such as glutamate that activate post-synaptic receptors. The amplitude of the post-synaptic current, mostly mediated by glutamatergic (AMPARs) receptors, is a fundamental signal that may generate an action potential.
arxiv +1 more source
FGF-2 Induces Neuronal Death through Upregulation of System xc- [PDF]
, 2014 The cystine/glutamate antiporter (system xc-) transports cystine into cell in exchange for glutamate. Fibroblast growth factor-2 (FGF-2) upregulates system xc- selectively on astrocytes, which leads to increased cystine uptake, the substrate for ...
Albano, Rebecca +2 more
core +1 more source
Journal of Neuroscience, 2015 Whereas consolidation and reconsolidation are considered dynamic processes requiring protein synthesis, memory retrieval has long been considered a passive readout of previously established plasticity.
Joëlle Lopez +3 more
semanticscholar +1 more source
Structure and function of AMPA receptors [PDF]
The Journal of Physiology, 2004 The application of X‐ray diffraction has allowed the structure of the ligand‐binding core of AMPA receptors to be determined. Here I review the insights that this has given into the molecular mechanisms of activation and desensitization of these receptors.
openaire +3 more sources
D2HGDH Deficiency Regulates Seizures through GSH/Prdx6/ROS‐Mediated Excitatory Synaptic Activity
Advanced Science, EarlyView.Downregulating D‐2‐hydroxyglutarate dehydrogenase (D2HGDH) increases epilepsy susceptibility by altering reactive oxygen species (ROS) levels and synaptic function, contributing to oxidative stress in neurons. The acid calcium‐independent phospholipase A2 (aiPLA2) inhibitor MJ33 restores glutathione reduced/glutathione oxidized balance, reducing ROS ...
Zhijuan Zhang +14 more
wiley +1 more source
An Analytically Solvable Model of Firing Rate Heterogeneity in Balanced State Networks [PDF]
arXiv, 2023 Distributions of neuronal activity within cortical circuits are often found to display highly skewed shapes with many neurons emitting action potentials at low or vanishing rates, while some are active at high rates. Theoretical studies were able to reproduce such distributions, but come with a lack of mathematical tractability, preventing a deeper ...
arxiv