Results 101 to 110 of about 2,293,512 (363)

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Animal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam, Md. Ibrahim Khalil Al‐Imran, Mehrukh Zehravi, Sherouk Hussein Sweilam, Mohammad Rakib Mortuza, Jeetendra Kumar Gupta, Thukani Sathanantham Shanmugarajan, Kadirvel Devi, Tanuja Tummala, Mohammed Ali Alshehri, Kalirajan Rajagopal, Mohammed Asiri, Irfan Ahmad, Talha Bin Emran   +13 more
wiley   +1 more source

The essential role of AMPA receptor GluR2 subunit RNA editing in the normal and diseased brain

Frontiers in Molecular Neuroscience, 2012
AMPA receptors are comprised of different combinations of GluR1-GluR4 (also known as GluA1-GluA4 and GluR-A to GluR-D) subunits. The GluR2 subunit is subject to Q/R site RNA editing by the ADAR2 enzyme, which converts a codon for glutamine (Q), present ...
Amanda Lorraine Wright, Amanda Lorraine Wright, Bryce eVissel, Bryce eVissel   +3 more
doaj   +1 more source

Assembly of AMPA receptors: mechanisms and regulation

Journal of Physiology, 2014
AMPA receptors (AMPARs) play a critical role in excitatory glutamatergic neurotransmission. The number and subunit composition of AMPARs at synapses determines the dynamics of fast glutamatergic signalling.
Quan Gan, Catherine L. Salussolia, L. Wollmuth   +2 more
semanticscholar   +1 more source

PhotonSABER: new tool shedding light on endocytosis and learning mechanisms in vivo

Communicative & Integrative Biology, 2019
In the central nervous system, activity-dependent endocytosis of postsynaptic AMPA-type glutamate receptors (AMPA receptors) is thought to mediate long-term depression (LTD), which is a synaptic plasticity model in various neuronal circuits.
Shinji Matsuda, Wataru Kakegawa, Michisuke Yuzaki   +2 more
doaj   +1 more source

Auxiliary Subunits: Shepherding AMPA Receptors to the Plasma Membrane

Membranes, 2014
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated cation channels that mediate excitatory signal transmission in the central nervous system (CNS) of vertebrates.
Simon Häring, D. Tapken, Steffen Pahl, M. Hollmann   +3 more
semanticscholar   +1 more source

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

Molecular Brain, 2018
N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission.
Sun Huang, Lina Chen, Chris Bladen, Peter K. Stys, Gerald W. Zamponi   +4 more
doaj   +1 more source

The role of AMPA receptors in postsynaptic mechanisms of synaptic plasticity

Frontiers in Cellular Neuroscience, 2014
In the mammalian central nervous system, excitatory glutamatergic synapses harness neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs).
T. Chater, Y. Goda
semanticscholar   +1 more source

Recognition of glycine versus non‐glycine citrulline motifs dictates the HLA class II association of anti‐citrullinated protein antibodies ‐ insights from autoantibody profiling of 6900 Scandinavian rheumatoid arthritis patients

Arthritis &Rheumatology, Accepted Article.
Objectives Rheumatoid arthritis (RA) associated anti‐citrullinated protein antibodies (ACPA) target various antigens by binding short citrulline‐amino acid motifs, resulting in heterogeneous ACPA‐profiles among patients. Here we analyzed ACPA‐patterns by recognized citrulline‐motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE ...
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Oliver Hendricks, Estrid Høgdall, Tue Wenzel Kragstrup, Dorte Vendelbo Jensen, Heidi Lausten Munk, Jens Kristian Pedersen, Torkell Ellingsen, Anne Gitte Loft, Ellen‐Margrethe Hauge, Salome Kristensen, Lene Dreyer, Asta Linauskas, Søren Jacobsen, Johan Askling, Caroline Grönwall   +31 more
wiley   +1 more source

AMPA, NMDA and GABAA receptor mediated network burst dynamics in cortical cultures in vitro [PDF]

Proc. Int. Works. Comp. Syst. Biol. TICSP series 8 (2011) 181-184, 2018
In this work we study the excitatory AMPA, and NMDA, and inhibitory GABAA receptor mediated dynamical changes in neuronal networks of neonatal rat cortex in vitro. Extracellular network-wide activity was recorded with 59 planar electrodes simultaneously under different pharmacological conditions.
arxiv  

AMPA-Net: Optimization-Inspired Attention Neural Network for Deep Compressed Sensing [PDF]

2020 IEEE 20th International Conference on Communication Technology(Oral), 2020
Compressed sensing (CS) is a challenging problem in image processing due to reconstructing an almost complete image from a limited measurement. To achieve fast and accurate CS reconstruction, we synthesize the advantages of two well-known methods (neural network and optimization algorithm) to propose a novel optimization inspired neural network which ...
arxiv