Results 101 to 110 of about 2,326,770 (324)

Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors

Cell Reports, 2019
Summary: Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by
Rong-wei Zhang, Wen-jie Du, David A. Prober, Jiu-lin Du   +3 more
doaj   +1 more source

Natural Products Targeting Protein Disulfide Isomerases: New Frontiers for Diabetes, Cancer, and Coagulation

Food Frontiers, EarlyView.
PDIA4 is significantly upregulated in response to nutrient overload in pancreatic β‐cells, resulting in aberrant ROS production, β‐cell failure, and diabetes. PDIA4 facilitates cancer development by inhibiting caspase‐mediatedcell death in cancer and promoting VEGF‐mediated protumoral immunity andangiogenesis in the tumor microenvironment, highlighting
Yi‐San Lee, Catherine Ortega, Tien‐Fen Kuo, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression

Cell Reports, 2019
Summary: Myosin VI is an actin-based cytoskeletal motor implicated in various steps of membrane trafficking. Here, we investigated whether this myosin is crucial for synaptic function and plasticity in neurons.
Wolfgang Wagner, Kristina Lippmann, Frank F. Heisler, Kira V. Gromova, Franco L. Lombino, Mona K. Roesler, Yvonne Pechmann, Sönke Hornig, Michaela Schweizer, Simona Polo, Jürgen R. Schwarz, Jens Eilers, Matthias Kneussel   +12 more
doaj   +1 more source

Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing

Glia, EarlyView.
Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production. ABSTRACT In the hypothalamus, detection of energy substrates such as glucose is essential to regulate ...
Sarah Geller, Nadège Zanou, Sylviane Lagarrigue, Tamara Zehnder, Cathy Gouelle, Tania Santoro, Cendrine Repond, Paola Bezzi, Francesca Amati, Anne‐Karine Bouzier‐Sore, Ariane Sharif, Luc Pellerin   +11 more
wiley   +1 more source

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Autoantibodies to Epilepsy-Related LGI1 in Limbic Encephalitis Neutralize LGI1-ADAM22 Interaction and Reduce Synaptic AMPA Receptors

Journal of Neuroscience, 2013
More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 haploinsufficiency is thought to cause ADLTE, the underlying molecular mechanism that results in
Toshika Ohkawa, Y. Fukata, Miwako Yamasaki, T. Miyazaki, Norihiko Yokoi, H. Takashima, Masahiko Watanabe, O. Watanabe, M. Fukata   +8 more
semanticscholar   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source

Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of αCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades

Kidney Research and Clinical Practice, 2014
Background: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and α isoform of calcium/calmodulin-dependent protein kinase II (αCaMKII) is fundamentally ...
Jong Wan Kim, Gyoung Yim Ha, Yong Wook Jung   +2 more
doaj   +1 more source

Calcium-Permeable AMPA Receptors in the Nucleus Accumbens Regulate Depression-Like Behaviors in the Chronic Neuropathic Pain State

Journal of Neuroscience, 2013
Depression is a salient emotional feature of chronic pain. Depression alters the pain threshold and impairs functional recovery. To date, however, there has been limited understanding of synaptic or circuit mechanisms that regulate depression in the pain
Yossef Goffer, Duo Xu, Sarah E. Eberle, James A. D’Amour, Michelle Lee, David S. Tukey, R. Froemke, E. Ziff, Jing Wang   +8 more
semanticscholar   +1 more source

Calcium-Permeable AMPA Receptors in the Retina [PDF]

Frontiers in Molecular Neuroscience, 2011
The retina transforms light entering the eye into a sophisticated neural representation of our visual world. Specialized synapses, cells, and circuits in the retina have evolved to encode luminance, contrast, motion, and other complex visual features. Although a great deal has been learned about the cellular morphology and circuitry that underlies this
openaire   +4 more sources