Results 161 to 170 of about 2,293,512 (363)

The cerebellum in epilepsy

open access: yesEpilepsia, EarlyView.
Abstract The cerebellum, a subcortical structure, is traditionally linked to sensorimotor integration and coordination, although its role in cognition and affective behavior, as well as epilepsy, is increasingly recognized. Cerebellar dysfunction in patients with epilepsy can result from genetic disorders, antiseizure medications, seizures, and seizure‐
Christopher Elder   +4 more
wiley   +1 more source

A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains

open access: yesThe FEBS Journal, EarlyView.
Transmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Ryan S. Dowsell, Matthew G. Gold
wiley   +1 more source

Cryo-electron tomographic investigation of native hippocampal glutamatergic synapses

open access: yeseLife
Chemical synapses are the major sites of communication between neurons in the nervous system and mediate either excitatory or inhibitory signaling.
Aya Matsui   +9 more
doaj   +1 more source

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome. [PDF]

open access: yesFront Mol Neurosci, 2023
Chojnacka M   +7 more
europepmc   +1 more source

Natural aminosterols inhibit NMDA receptors with low nanomolar potency

open access: yesThe FEBS Journal, EarlyView.
Misfunction of N‐methyl‐D‐aspartate (NMDA) receptors is associated with many brain disorders, making them primary targets for drug discovery. Trodusquemine and other natural aminosterols inhibit NMDA receptors with low nanomolar potency through binding to the cell membranes followed by interaction with the channels.
Giulia Fani   +9 more
wiley   +1 more source

Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors

open access: yesCell Reports, 2019
Summary: Retinal waves, the spontaneous patterned neural activities propagating among developing retinal ganglion cells (RGCs), instruct the activity-dependent refinement of visuotopic maps. Although it is known that the wave is initiated successively by
Rong-wei Zhang   +3 more
doaj  

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