Results 61 to 70 of about 2,293,512 (363)

Development of AMPA Receptor Aptamers [PDF]

Biophysical Journal, 2010
The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) subtype of glutamate ion channel receptors plays an essential role in the mammalian brain activities such as memory and learning, whereas the excessive receptor activation has been implicated in neurological diseases such as stroke, epilepsy, and amyotrophic lateral sclerosis.
Zhen Huang, Weimin Pei, Sabarinath Jayaseelan, Li Niu, Yan Han, Jae Seon Park   +5 more
openaire   +2 more sources

Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons

Frontiers in Molecular Neuroscience, 2021
Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb, Ali Harb, Nils Vogel, Ali Shaib, Ute Becherer, Dieter Bruns, Ralf Mohrmann, Ralf Mohrmann   +7 more
doaj   +1 more source

PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus

Nature Communications, 2021
Long-term potentiation at hippocampal CA1 synapses can be due to increasing the number and/or single-channel conductance of AMPA receptors. The authors show that PKA and CaMKII are necessary and together sufficient to increase single channel conductance,
Pojeong Park, John Georgiou, Thomas M. Sanderson, Kwang-Hee Ko, Heather Kang, Ji-il Kim, Clarrisa A. Bradley, Zuner A. Bortolotto, Min Zhuo, Bong-Kiun Kaang, Graham L. Collingridge   +10 more
doaj   +1 more source

Single NanoParticle Photothermal Tracking (SNaPT) of 5 nm gold beads in live cells [PDF]

Biophysical Journal 91, 12 (15/12/2006) 4598, 2007
Tracking individual nano-objets in live cells during arbitrary long times is an ubiquitous need in modern biology. We present here a method for tracking individual 5 nm gold nanoparticles on live cells. It relies on the photothermal effect and the detection of the Laser Induced Scattering around a NanoAbsorber (LISNA).
arxiv   +1 more source

Ligand‐directed delivery of fluorophores to track native calcium‐permeable AMPA receptors in neuronal cultures

Journal of Neurochemistry, 2015
Subcellular trafficking of neuronal receptors is known to play a key role in synaptic development, homeostasis, and plasticity. We have developed a ligand‐targeted and photo‐cleavable probe for delivering a synthetic fluorophore to AMPA receptors ...
Rosamund E Combs-Bachmann, Jeffreys N Johnson, Devaiah Vytla, A. M. Hussey, M. Kilfoil, J. Chambers   +5 more
semanticscholar   +1 more source

Mechanisms of AMPA Receptor Endosomal Sorting [PDF]

Frontiers in Molecular Neuroscience, 2018
The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes.
Parkinson, Gabrielle T., Hanley, Jonathan G.   +1 more
openaire   +6 more sources

Superactivation of AMPA receptors by auxiliary proteins [PDF]

Nature Communications, 2016
AbstractGlutamate receptors form complexes in the brain with auxiliary proteins, which control their activity during fast synaptic transmission through a seemingly bewildering array of effects. Here we devise a way to isolate the activation of complexes using polyamines, which enables us to show that transmembrane AMPA receptor regulatory proteins ...
Andrew J.R. Plested, Andrew J.R. Plested, Anna L. Carbone   +2 more
openaire   +4 more sources

Degradation of Glyphosate to Benign N‐Formyl Glycine Using MOF‐808 Nanocrystals

Angewandte Chemie, EarlyView.
A Zr‐based metal–organic framework (MOF‐808) with different crystal sizes and designed defect sites was employed as an efficient heterogeneous catalyst for the complete degradation of glyphosate at room temperature. The degradation mechanism produces N‐formyl glycine and hydroxymethyl‐phosphonate. Abstract Glyphosate (N‐phosphonomethyl glycine, GPh) is
Jhair A. Peña Prada, Tatiana A. Huertas Navarro, Stephange L. Chua, Alejandro M. Granados, Chih‐Wen Pao, Alejandro M. Fracaroli, Nicholas M. Bedford   +6 more
wiley   +2 more sources

Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications*

Journal of Biological Chemistry, 2015
Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory.
M. Lussier, A. Sanz-Clemente, K. Roche
semanticscholar   +1 more source

Exploiting the molecular diversity of the synapse to investigate neuronal communication: A guide through the current toolkit

European Journal of Neuroscience, Volume 56, Issue 12, Page 6141-6161, December 2022., 2022
Chemical synapses are tiny and overcrowded environments enriched with thousands of protein species. Many efforts have been devoted to developing sensors and actuators able to evaluate and control synaptic communication. Most of these recent tools are based on the engineering of one or more specific synaptic proteins used to target active moieties to ...
Jacopo Lamanna, Mattia Ferro, Sara Spadini, Antonio Malgaroli   +3 more
wiley   +1 more source