Results 91 to 100 of about 14,068 (191)

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, Volume 599, Issue 22, Page 3284-3300, November 2025.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Diffusion of extended-spectrum and plasmid-mediated amp-C β-lactamase producing Proteus mirabilis in hospitals and community setting in Croatia

Journal of Global Antimicrobial Resistance
AIM: We report the characteristics of extended-spectrum β-lactamases (ESBLs) and plasmid-mediated AmpC β-lactamases (p-AmpC), encountered among hospital and community isolates of [P. mirabilis].
Branka Bedenić, Nataša Beader, Marina Nađ, Haris Car, Mladen Pospišil, Mirela Dobrić, Jasmina Vraneš   +6 more
doaj   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Antibiotics as selectors and accelerators 1 of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world [PDF]

, 2013
Antibiotics and antibiotic resistance determinants, natural molecules closely related to bacterial physiology and consistent with an ancient origin, are not only present in antibiotic-producing bacteria.
Cantón, Rafael, Galán, Juan Carlos, González Candelas, Fernando, Rolain, Jean-Marc   +3 more
core   +3 more sources

Molecular Detection of AmpC Beta-Lactamase Genes Involved in Antibiotic Resistance of Klebsiella pneumoniae Strains Isolated from Intensive Care Unit Patients of Pasteur Hospital in Bam City, Iran

Indian Journal of Medical Specialities
Background: Klebsiella pneumoniae is a well-known opportunistic pathogen that can cause a variety of human infections and has the ability to form biofilm.
Seyed Mojtaba Mortazavi, Tahereh Navidifar, Monireh Bazdar, Amirreza Nabizade Qomi, Masoomeh Ghasemi, Saeed Khoshnood, Rezvan Bagheri Baravati, Milad Abdi, Fatemeh Shahi   +8 more
doaj   +1 more source

Deep Pyoderma Caused by Serratia marcescens in a Border Collie in China

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
GRAPHICAL ABSTRACT A 4‐year‐old Border Collie with deep pyoderma caused by Serratia marcescens exhibited erythematous patches over the abdomen and ruptured pustules scattered on the back. The dog was successfully treated with marbofloxacin at 2.7 mg/kg once daily.
Ran Wang, Ying Jiao, Yang Liu, Di Zhang
wiley   +1 more source

Analysis for prevalence and physical linkages amongst integrons, ISEcp1, ISCR1, Tn21 and Tn7 encountered in Escherichia coli strains from hospitalized and non-hospitalized patients in Kenya during a 19-year period (1992-2011) [PDF]

, 2013
Background: We determined the prevalence and evidence for physical linkage amongst integrons, insertion sequences, Tn21 and Tn7 transposons in a collection of 1327 E. coli obtained over a 19-year period from patients in Kenya.
Butaye, Patrick, Goddeeris, Bruno, Kariuki, Samuel, Kiiru, John   +3 more
core   +3 more sources

Virulence and Antibiotic Resistance Profiles of Proteus mirabilis Strains Isolated From Broiler Chickens: Implications for Poultry and Public Health

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
Proteus mirabilis strains isolated from broilers exhibited multidrug resistance, strong biofilm formation and diverse virulence genes, highlighting poultry as potential reservoirs of zoonotic pathogens and emphasizing the need for monitoring antimicrobial resistance and virulence in poultry production.
Mohammad Reza Mohammadi, Niloofar Kiaheyrati, Mohadeseh Khakpour, Fatemeh Fardsanei, Fariba Najar Hoseini, Sona Sobhani, Mahsa Fallah Zavaraki, Gita Khorami Ejlali, Nazanin Alijani, Farhad Nikkhahi   +9 more
wiley   +1 more source

Selection of mutants with resistance or diminished susceptibility to ceftazidime/avibactam from ESBL- and AmpC- producing Enterobacteriaceae [PDF]

, 2018
Introduction: Difficult Gram-negative infections are increasingly treated with new β-lactamase inhibitor combinations, e.g. ceftazidime/avibactam.
Doumith, Michel, Jamrozy, Dorota, Livermore, David M., Mushtaq, Shazad, Nichols, Wright W., Woodford, Neil   +5 more
core   +1 more source

Microbiological Characteristics of Pathogens Isolated From Blood Cultures of Patients With Acute Cholangitis: Insights From Patients With Biliary‐Enteric Anastomosis

Journal of Hepato-Biliary-Pancreatic Sciences, Volume 32, Issue 10, Page 766-776, October 2025.
Kuhara and colleagues analyzed 366 cases of bacteremic acute cholangitis, focusing on pathogens isolated from blood cultures. Escherichia coli and Klebsiella spp. predominated overall, whereas ESCPM organisms were significantly more frequent in patients with prior biliary‐enteric anastomosis or intervention, highlighting the importance of considering ...
Yuta Kuhara, Hiroki Kitagawa, Yuki Kaiki, Keitaro Omori, Norifumi Shigemoto, Tomoyuki Akita, Kenichiro Uemura, Shingo Fukuma, Shinya Takahashi, Hiroki Ohge   +9 more
wiley   +1 more source