This study highlights the prevalence of multidrug‐ and carbapenem‐resistant Pseudomonas aeruginosa in pediatric cystic fibrosis patients, along with the presence of carbapenemase‐encoding genes and genetic profiles, suggesting clonal spread. These findings underscore the urgent need for surveillance and strategies to combat resistant strains and ...
Erfaneh Jafari +5 more
wiley +1 more source
Cefotaxime for the detection of extended-spectrum β-lactamase or plasmid-mediated AmpC β-lactamase and clinical characteristics of cefotaxime-non-susceptible Escherichia coli and Klebsiella pneumoniae bacteraemia. [PDF]
We investigated the performance of cefotaxime for the detection of extended-spectrum β-lactamase (ESBL) or plasmid-mediated AmpC β-lactamase (pAmpC) and the clinical characteristics of cefotaxime-non-susceptible Escherichia coli or Klebsiella pneumoniae (
Ichiyama, S +6 more
core +1 more source
First Report of CTX-M-32 and CTX-M-101 in Proteus mirabilis from Zagreb, Croatia
Background/Objectives: Proteus mirabilis is a frequent causative agent of urinary tract and wound infections in community and hospital settings. It develops resistance to expanded-spectrum cephalosporins (ESC) due to the production of extended-spectrum β-
Branka Bedenić +9 more
doaj +1 more source
Reversing Antibiotic Resistance: Strategies From Adjuvants to Innovative Therapeutics
Molecular reversal strategies against antibiotic resistance act through three mechanisms: inhibiting resistance gene function, blocking horizontal gene transfer, and modulating host defense. Emerging technologies, such as CRISPR‐Cas gene editing, photodynamic therapy, nanotechnology, and ecological competition, further strengthen these approaches ...
Tianjiao Li +4 more
wiley +1 more source
Characterization of cefotaxime resistant Escherichia coli isolated from broiler farms in Ecuador [PDF]
Antimicrobial resistance (AR) is a worldwide concern. Up to a 160% increase in antibiotic usage in food animals is expected in Latin American countries.
De Zutter, Lieven +4 more
core +2 more sources
Extended-spectrum β-lactamases (ESBLs) and AmpC β-lactamases are key mechanisms behind β-lactam antibiotic resistance, particularly in Gram-negative bacteria. In Nepal, antibiotic-resistant bacterial infections pose a growing public health concern among
Pratima Nyaupane +3 more
doaj +1 more source
This study reveals estragole's bactericidal activity against MDR/XDR Gram‐negative pathogens. Synergy with meropenem and tobramycin was observed in > 88% of strains, reducing antibiotic MICs up to 16‐fold. Estragole represents a promising therapeutic adjuvant to enhance antibiotic efficacy and combat antimicrobial resistance.
María Araque, Luis B. Rojas
wiley +1 more source
Public Health Risks of Enterobacterial Isolates Producing Extended-Spectrum β-Lactamases or AmpC β-Lactamases in Food and Food-Producing Animals: An EU Perspective of Epidemiology, Analytical Methods, Risk Factors, and Control Options [PDF]
The blaESBL and blaAmpC genes are spread by plasmid-mediated integrons, insertion sequences, and transposons, some of which are homologous in food animals and humans.
Carattoli, Alessandra +14 more
core
Multiparametric determination of genes and their point mutations for identification of beta-lactamases [PDF]
More than half of all currently used antibiotics belong to the beta-lactam group, but their clinical effectiveness is severely limited by antibiotic resistance of microorganisms that are the causative agents of infectious diseases. Several mechanisms for
A. A. Medeiros +127 more
core +1 more source
Background and Objectives: Pseudomonas aeruginosa is responsible for devastating nosocomial infections among severely burn patients. Class C of cephalosporinase (AmpC-β-lactamases) is important cause of multiple β-lactam resistance in P.
Akbar Mirsalehian +6 more
doaj

