Results 121 to 130 of about 276 (135)

Structures of new amphidinols with truncated polyhydroxyl chain and their membrane-permeabilizing activities

Bioorganic & Medicinal Chemistry, 2006
Two new homologues of amphidinols (AM14 and AM15) were isolated from the cultured dinoflagellate Amphidinium klebsii. The structures were elucidated on the basis of 2D NMR and collision-induced dissociation MS/MS and turned out to be closely related homologues of AM7.
Nagy, Morsy, Toshihiro, Houdai, Shigeru, Matsuoka, Nobuaki, Matsumori, Seiji, Adachi, Tohru, Oishi, Michio, Murata, Takashi, Iwashita, Tsuyoshi, Fujita   +8 more
openaire   +2 more sources

Diastereoselective synthesis of the C14–C29 fragment of amphidinol.

Organic & biomolecular chemistry, 2014
An efficient stereoselective synthesis of the C14–C29 fragment highlighting a coupling reaction between a 1,3-dithiane derivative and an α-branched aldehyde was realized. This highly convergent synthesis involved two chiral pools, L-malic acid and (+)-camphorsulfonic acid, which are the starting compounds to control the six stereogenic centers present ...
Nicolas, Rival, Gilles, Hanquet, Charlelie, Bensoussan, Sébastien, Reymond, Janine, Cossy, Françoise, Colobert   +5 more
openaire   +1 more source

Structure and Biosynthesis of Amphidinol 17, a Hemolytic Compound from Amphidinium carterae

Journal of Natural Products, 2010
Amphidinol 17 (AM17; 1), a novel amphidinol, has been isolated from a Bahamas strain of Amphidinium carterae. This new congener contains the signature hairpin region and a Delta(6) polyene arm, whereas the polyol arm is distinct from those of other amphidinols.
Yanhui, Meng, Ryan M, Van Wagoner, Ian, Misner, Carmelo, Tomas, Jeffrey L C, Wright   +4 more
openaire   +2 more sources

Acetate labeling patterns of dinoflagellate polyketides, amphidinols 2, 3 and 4

Tetrahedron, 2001
Abstract Amphidinols, which are polyketide metabolites chiefly comprising a long linear chain with polyhydroxyl groups and polyolefins, are produced by marine dinoflagellates Amphidinium carterae and A. klebsii. The acetate incorporation experiments of amphidinols 2, 3 and 4 revealed that they are built up with five regular C2-elongation sequences ...
Toshihiro Houdai, Shigeru Matsuoka, Michio Murata, Masayuki Satake, Sayo Ota, Yasukatsu Oshima, Lesley L Rhodes   +6 more
openaire   +1 more source

Hairpin conformation of amphidinols possibly accounting for potent membrane permeabilizing activities

Tetrahedron, 2005
Amphidinols are a unique dinoflagellate metabolite with potent antifungal activity. We examined membrane permeabilizing action by amphidinol analogues with structural variations in polyhydroxy and polyene moieties. Consequently, the polyene and polyhydroxy moieties turned out to play important roles in binding to lipid bilayer membrane and in forming ...
Toshihiro Houdai, Shigeru Matsuoka, Nagy Morsy, Nobuaki Matsumori, Masayuki Satake, Michio Murata   +5 more
openaire   +1 more source

The structures of five new antifungal and hemolytic amphidinol analogs from Amphidinium carterae collected in New Zealand

Harmful Algae, 2005
Yasukatsu Oshima, Masayuki Satake
exaly  

Amphidinol 22, a New Cytotoxic and Antifungal Amphidinol from the Dinoflagellate Amphidinium carterae

Marine Drugs, 2019
Kevin A Martinez, Chiara Lauritano, Giovanna Romano   +2 more
exaly  

Sterol effect on interaction between amphidinol 3 and liposomal membrane as evidenced by surface plasmon resonance

Bioorganic and Medicinal Chemistry Letters, 2010
Nagy Morsy, Nobuaki Matsumori, Tohru Oishi   +2 more
exaly  

Synthesis of an Analog of Amphidinol 3 Corresponding to the C31–C67 Section

HETEROCYCLES, 2018
Tohru Oishi, Tomoyuki Koge, Makoto Ebine
openaire   +1 more source

Synthesis of a Truncated Analog of Amphidinol 3 Corresponding to the C21–C39/C52–C67 Section

Chemistry Letters, 2017
Makoto Ebine, Yuri Takada, Tohru Oishi   +2 more
exaly