Results 31 to 40 of about 374,595 (258)

Comparative pharmacokinetics of amphotericin B after single- and multiple-dose administration of G-ABCD and conventional amphotericin B deoxycholate to rats

Journal of Global Antimicrobial Resistance, 2020
Objective: G-ABCD is a biosimilar product of amphotericin B colloidal dispersion (ABCD). This study was designed to systematically examine the plasma pharmacokinetics (PK) and tissue distribution of G-ABCD in rats, using amphotericin B deoxycholate (DAmB)
Huanhuan Qi, Xueyuan Zhang, Hao Feng, Yating Xiong, Yuancheng Chen, Jing Zhang, Chunlei Li   +6 more
doaj  

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering

Advanced Materials Technologies, EarlyView.
Electrospinning enables the hierarchical assembly of nanofiber‐based scaffolds for tissue engineering. However, encapsulated proteins often undergo structural changes. This study used mesoporous silica nanoparticles (MSNs) as protective carriers, mitigating protein denaturation and supporting controlled release.
Vera Citro, Marta Clerici, Matthew T. Shephard, Tina P. Dale, Aldo R. Boccaccini, Nicholas R. Forsyth   +5 more
wiley   +1 more source

Investigation of the Decay of Orbitally-Excited B Mesons and First Measurement of the Branching Ratio BR(B*_J->B*pi(X)) [PDF]

Eur.Phys.J.C23:437-454,2002, 2000
From about 4 million hadronic Z decays recorded by the OPAL detector on and near to the Z resonance, we select a sample of more than 570000 inclusively reconstructed B mesons. Orbitally-excited mesons B*J are reconstructed using Bpi+- combinations. Independently, B* mesons are reconstructed using the decay B* -> Bgamma.
arxiv   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

A Theoretical Prediction for Exclusive Decays $B \rightarrow K(K^*) η_c$ [PDF]

Z. Phys. C65 (1995) 263-266, 1994
The decay rates for the exclusive B decays $B \rightarrow K \eta_c $ and $B \rightarrow K^* \eta_c$ are calculated in the context of the heavy quark effective theory. We obtain $\Gamma (B \rightarrow K \eta_c )/\Gamma (B\rightarrow K\psi )=1.6 \pm 0.2$ and $\Gamma (B\rightarrow K^*\eta_c)/\Gamma (B \rightarrow K^*\psi )=0.39 \pm 0.04$.
arxiv   +1 more source

Sugar Functionalized Collagen Material for Local Modulation of Innate Immunity

Advanced Science, EarlyView.
Modulation of the innate immune response at the implant site can significantly influence adaptive immunity. A mannose‐functionalized collagen patch, termed the Local Immunotuning Patch (LIP), has been designed to engage mannose receptors on antigen‐presenting cells while exhibiting antibacterial properties. LIP orchestrates complex immune pathways that
Francesca Taraballi, Claudia Corbo, Julia Enterria‐Rosales, John Otto Martinez, Silvia Minardi, Laura Pandolfi, Xing Wang, Ennio Tasciotti, Kavindra V. Singh, Cesar A. Arias, Bruna Corradetti   +10 more
wiley   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery

Aggregate, EarlyView.
This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail, Guangze Yang, Yilong Fan, Yue Hui, Chun‐Xia Zhao, Yun Liu   +5 more
wiley   +1 more source

Amphotericin B deoxycholate for relapse visceral leishmaniasis in Bangladesh: a cross-sectional study

BMC Research Notes, 2018
Objective Based on studies in India (as there was no studies from outside India) amphotericin B deoxycholate has been considered as a backup drug for treatment of visceral leishmaniasis.
Md Golam Hasnain, Proggananda Nath, Shomik Maruf, Shah Golam Nabi, A. F. M. Akhtar Hossain, Be-Nazir Ahmed, Dinesh Mondal, Ariful Basher   +7 more
doaj   +1 more source

Sharp Bounds for Neuman Means in Terms of Geometric, Arithemtic and Quadratic Means [PDF]

arXiv, 2014
In this paper, we find the greatest values $\alpha_{1}$, $\alpha_{2}$, $\alpha_{3}$, $\alpha_{4}$, $\alpha_{5}$, $\alpha_{6}$, $\alpha_{7}$, $\alpha_{8}$ and the least values $\beta_{1}$, $\beta_{2}$, $\beta_{3}$, $\beta_{4}$, $\beta_{5}$, $\beta_{6}$, $\beta_{7}$, $\beta_{8}$ such that the double inequalities $$A^{\alpha_{1}}(a,b)G^{1-\alpha_{1}}(a,b)<
arxiv