Results 161 to 170 of about 117,713 (263)

Sotagliflozin ameliorates doxorubicin-induced cardiomyopathy by regulating inflammation and mitochondrial dysfunction through the AMPK/mTOR pathway. [PDF]

Exp Ther Med
Liu H, Han D, Li M.
europepmc   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source

Translational control of AMPK activity in melanoma. [PDF]

Cell Commun Signal
Vadovičová N, Lešková A, Koždoňová K, Smolková K, Valčíková B, Kafka F, Potěšil D, Zdráhal Z, Vacek O, Víchová R, Souček K, Uldrijan S.   +11 more
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions. [PDF]

Pharmacol Res Perspect
Hosseini SA, Valadbeigi H, Khoshnazar SM, Khoshnood S, Falahi S, Rezaee D, Hematian A, Haddadi MH.   +7 more
europepmc   +1 more source

miRNA Profiling of Cholesteatoma‐Derived Exosomes Reveals Exosomal miR‐223‐3p and miR‐142‐5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Acquired cholesteatoma is an abnormal and invasive growth of keratinized squamous epithelial cells in the middle ear. The study aims to explore the role of exosomal miRNAs in the pathogenesis of acquired cholesteatoma and their potential in clinical application.
Qi Tang, Meng‐Yao Xie, Shu Wang, Zhi‐Yuan Wu, Zhi‐Jin Han, Chen Li, Shu‐Yi Wang, Yuan Cao, Yu‐Run Chen, Bin Wang, Ying‐Ying Shang, Xiao‐Wu Huang, Hua Yang   +12 more
wiley   +1 more source

Molecular Hydrogen as a Regulator of Mitochondrial Quality Control and Metabolic Reprogramming. [PDF]

Int J Mol Sci
Li F, Jing Y, Xia C, Zhao R, Liu M, Zhao P, Ma X, Xie F.   +7 more
europepmc   +1 more source

Increased energetic cost of movement reduces reproductive output in zebrafish at different temperatures and water flow rates

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Locomotion consumes a large proportion of individual energy budgets and may impose energetic constraints on other fitness‐related traits particularly under variable environmental conditions.
Miki Jahn, Frank Seebacher
wiley   +1 more source

Potential Relationship Between YTHDF3 and CFTR in Myocardial Ischemia-Reperfusion Injury. [PDF]

J Cell Mol Med
Tang B, Zhu C, Wang H, Gao M, Li T.
europepmc   +1 more source

Multi‐Omics Analysis Reveals Coordinated Adaptations in Genes, Metabolism, and Gut Microbiota Underpinning Herbivory in Lordiphosa Flies

Integrative Zoology, EarlyView.
Multi‐omics analysis reveals that herbivorous adaptation in Lordiphosa flies arises from coordinated interactions across the genome, transcriptome, and gut microbiota: genomic expansions of detoxification (e.g., cytochrome P450s) and carbohydrate metabolism gene families, transcriptomic upregulation of energy pathways like lipid oxidation and ...
Run Guo, Jianjun Gao, Caixian Zhang, Zhiheng Chang, Yanbo Sun   +4 more
wiley   +1 more source