Results 171 to 180 of about 118,042 (218)

Heat stress promotes ferroptosis in Jiaji duck myocardium by disrupting iron homeostasis and inducing lipid peroxidation. [PDF]

Poult Sci
Liang Q, Zheng X, Xu T, Liu P, Chen Y, Lin Z, Gu L.   +6 more
europepmc   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Metformin dual-targets metabolism and survival pathways in BPDCN. [PDF]

iScience
Mekkaoui Z, Dal Zuffo L, Vetter M, Fredon M, Poussard M, Biichle S, Mougey V, Mercier-Letondal P, Rolin G, Godet Y, Perruche S, Garnache-Ottou F, Saas P, Aribi M.   +13 more
europepmc   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

hUMSC-derived exosomes alleviate hypoxic cerebrovascular injury <i>via</i> AMPK/NLRP3-mediated pyroptosis suppression and mitochondrial protection. [PDF]

J Biomed Res
Liu J, Pan Y, Wu H, Guo Q, Fang X, Lu Y, Liu Q.   +6 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Binding of 14-3-3 stabilises recombinant AMPKγ2-containing complexes. [PDF]

Biochem J
Chen SY, Bennett J, Navaratnam N, Fiadeiro R, Woods A, Montoya A, Shliaha PV, Kunzelmann S, Howell SA, Mehmood S, Purkiss AG, Wilson JR, Gamblin SJ, Carling D.   +13 more
europepmc   +1 more source

Diabetes‐Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype

Neurourology and Urodynamics, EarlyView.
ABSTRACT Objective To explore molecular mechanisms underlying excessive extracellular adenosine (ADO) accumulation in the bladder lamina propria (LP) of mice with type 2 diabetes (T2D) induced by a high‐fat, high‐sucrose diet (HFHSD), conceivably leading to bladder underactivity.
Mahsa Borhani Peikani, Brian A. Perrino, Violeta N. Mutafova‐Yambolieva   +2 more
wiley   +1 more source

The Molecular Mechanisms of Metformin's Action on Blood Lipid Profile in Diabetic Patients. [PDF]

Int J Mol Sci
Dettlaff-Pokora A, Swierczynski J.
europepmc   +1 more source