Results 151 to 160 of about 117,713 (263)

A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism. [PDF]

JCI Insight
Wisessaowapak C, Skorobogatko Y, Kim H, Feng X, Son S, Fu H, Zhang S, Lertvilai P, Chang L, Hoang A, Chen H, Bedsted S, Valentine J, Huh JY, Zhao P, Reilly SM, Watcharasit P, Ahmadian M, Saltiel AR.   +18 more
europepmc   +1 more source

AMPK → ULK1 → Autophagy [PDF]

Molecular and Cellular Biology, 2011
openaire   +2 more sources

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

<i>Zingiber officinale</i> Leaf Subcritical Water Extract Suppresses Adipogenesis and Lipogenesis in 3T3-L1 Adipocytes via the AMPK-SREBP-1c Signaling Pathway. [PDF]

Int J Med Sci
Jun EM, Kim JY, Choe JS, Park EJ, Lee HJ.   +4 more
europepmc   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, EarlyView.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies. [PDF]

Cells
Rahman MA, Harrath AH, Jalouli M, Choi J, Choi M, Park S, Kim HJ, Rani A, Akter S, Park MN, Kim B.   +10 more
europepmc   +1 more source

AMPK inhibitors

, 2018
The 5'-AMP-activated protein kinase AMPK functions as a master switch to maintain cellular and whole-body energy homeostasis and abnormal activity profiles of AMPK may cause pathological disorders. The present invention relates to a series of compounds (I) based on a pyrrolo[2,3-c]pyridine and a thieno[2,3- c]pyridine scaffold as AMPK inhibitors.
openaire   +1 more source

Baicalein Sensitizes Radioresistant BT549 and MCF7‐R Breast Cancer Cells by Modulating Rac1 Signaling

Phytotherapy Research, EarlyView.
ABSTRACT Radioresistance remains a key barrier in breast cancer (BC) treatment. Baicalein, a flavonoid from Scutellaria baicalensis, has shown potential to enhance radiosensitivity. This study investigates its efficacy and mechanism in radioresistant BC models. Radioresistant BC cell models were established via fractionated irradiation and validated by
Zitong Zhao, Zhangyun Li, Quanzhou Peng, Shuqun Zhang   +3 more
wiley   +1 more source

Total Flavonoids of <i>Apocynum venetum</i> Ameliorate High-Fat Diet-Induced Lipid Accumulation in Mice and Hepatocytes by Activating the AMPK Signaling Pathway. [PDF]

Nutrients
Tang W, Ding W, Deng L, Wang D, Wang H, Li Y, Ma R.   +6 more
europepmc   +1 more source

Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death

Phytotherapy Research, EarlyView.
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi, Renda Chahna, Francesca Maffei, Alma Martelli, Vincenzo Calderone, Carmela Fimognari, Eleonora Turrini   +6 more
wiley   +1 more source