Results 11 to 20 of about 228,730 (331)
Communicative & Integrative Biology, 2012 Ion transport processes are highly energy consuming. It is therefore critical to couple ion transport processes to the metabolic state of the cell. An important player in this coupling appears to be the AMP-activated protein kinase (AMPK). This kinase becomes activated during conditions of cellular metabolic stress and is well-known for its role in ...
Dieter Böning +46 more
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AMPK and the Adaptation to Exercise.
Annual Review of Physiology, 2022 Noncommunicable diseases are chronic diseases that contribute to death worldwide, but these diseases can be prevented and mitigated with regular exercise.
H. Spaulding, Zhen Yan
semanticscholar +1 more source
Energy stress-mediated AMPK activation inhibits ferroptosis
Nature Cell Biology, 2020 Energy stress depletes ATP and induces cell death. Here we identify an unexpected inhibitory role of energy stress on ferroptosis, a form of regulated cell death induced by iron-dependent lipid peroxidation. We found that ferroptotic cell death and lipid
Hyemin Lee +12 more
semanticscholar +1 more source
Emerging Role of cAMP/AMPK Signaling
Cells, 2022 The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural energy sensor in mammalian cells that plays a key role in cellular and systemic energy homeostasis.
M. Aslam, Y. Ladilov
semanticscholar +1 more source
Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation [PDF]
International Journal of Molecular Sciences, 2020 A role for the cytoplasmic protein synphilin-1 in regulating energy balance has been demonstrated recently. Expression of synphilin-1 increases ATP levels in cultured cells. However, the mechanism by which synphilin-1 alters cellular energy status is unknown.
Tianxia Li +8 more
openaire +2 more sources
What’s new in chronic pain pathophysiology
Canadian Journal of Pain, 2020 The understanding of pain pathophysiology is continuously evolving. Identifying underlying cellular and subcellular pathways helps create opportunities for targeted therapies that may prove to be effective interventions. This article is an update on four
Ivan Cohen, Mark J. Lema
doaj +1 more source
Frontiers in Physiology, 2022 Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved catabolic process that involves an intracellular degradation system in which ...
Shengyuan Wang +4 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy (DN), and renal tubular injury might associate with abnormal mitophagy.
Yanlong Han +11 more
semanticscholar +1 more source
Available CALM (calmodulin) and autophagy: pas de deux at rest
Autophagy Reports, 2022 Macroautophagy/autophagy is a process that degrades unnecessary cellular components to maintain homeostasis. The Ca2+-sensing protein CALM (calmodulin) is needed for many cell functions yet is a limiting factor because of its insufficient availability ...
Elizabeth McConnaha +3 more
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AIMS Neuroscience, 2021 Hypoglycemia activates the ultra-sensitive energy gauge 5′-AMP-activated protein kinase (AMPK) in ventromedial hypothalamic nucleus (VMN) gluco-regulatory neurons.
MD Main Uddin, Karen P Briski
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