Results 11 to 20 of about 112,937 (259)
The neuroprotective effect of Rho-kinase Inhibition in 1-methyl-4-phenylpyridinium (MPP+)-induced cellular model of neurodegeneration [PDF]
Medicinski Podmladak, 2021 Introduction: The 1-methyl 4-phenyl 1,2,3,6-tetrahydropiridium (MPTP) induced model of neurodegeneration in Parkinson's disease (PD) is one of the most commonly used experimental models.
Blagojević Sanja +2 more
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Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits
Frontiers in Bioscience-Landmark, 2022 Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition,
Arthur J. Chu
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Melatonin postconditioning combined with sitagliptin exerts full cardioprotection in diabetic hearts of aged rats through an AMPK-dependent mechanism [PDF]
Archives of Biological Sciences, 2021 The presence of multiple comorbidities in patients facing myocardial ischemia-reperfusion (IR) injury is the main obstacle for cardioprotection. This study investigated the effect of melatonin postconditioning combined with sitagliptin pretreatment on ...
Song Ronggang +3 more
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Communicative & Integrative Biology, 2012 Ion transport processes are highly energy consuming. It is therefore critical to couple ion transport processes to the metabolic state of the cell. An important player in this coupling appears to be the AMP-activated protein kinase (AMPK). This kinase becomes activated during conditions of cellular metabolic stress and is well-known for its role in ...
Dieter Böning +46 more
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Environmental Health and Preventive Medicine, 2023 Background: In this study, we aimed to investigate the effects of acute and chronic resistance training of varying intensities on molecular responses and their association with muscular fitness in a cohort of young males who participated in this ...
Chongwen Zuo +4 more
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Synphilin-1 Interacts with AMPK and Increases AMPK Phosphorylation [PDF]
International Journal of Molecular Sciences, 2020 A role for the cytoplasmic protein synphilin-1 in regulating energy balance has been demonstrated recently. Expression of synphilin-1 increases ATP levels in cultured cells. However, the mechanism by which synphilin-1 alters cellular energy status is unknown.
Tianxia Li +8 more
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What’s new in chronic pain pathophysiology
Canadian Journal of Pain, 2020 The understanding of pain pathophysiology is continuously evolving. Identifying underlying cellular and subcellular pathways helps create opportunities for targeted therapies that may prove to be effective interventions. This article is an update on four
Ivan Cohen, Mark J. Lema
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IQGAP1 binds AMPK and is required for maximum AMPK activation [PDF]
Journal of Biological Chemistry, 2021 AMP-activated protein kinase (AMPK) is a fundamental component of a protein kinase cascade that is an energy sensor. AMPK maintains energy homeostasis in the cell by promoting catabolic and inhibiting anabolic pathways. Activation of AMPK requires phosphorylation by the liver kinase B1 or by the Ca2+/calmodulin-dependent protein kinase 2 (CaMKK2).
Andrew C. Hedman +5 more
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Available CALM (calmodulin) and autophagy: pas de deux at rest
Autophagy Reports, 2022 Macroautophagy/autophagy is a process that degrades unnecessary cellular components to maintain homeostasis. The Ca2+-sensing protein CALM (calmodulin) is needed for many cell functions yet is a limiting factor because of its insufficient availability ...
Elizabeth McConnaha +3 more
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Autophagy Function and Regulation in Kidney Disease
Biomolecules, 2020 Autophagy is a dynamic process by which intracellular damaged macromolecules and organelles are degraded and recycled for the synthesis of new cellular components.
Gur P. Kaushal +3 more
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