Results 71 to 80 of about 232,331 (307)
Peer Community JournalWe developed a python package called mbctools, designed to offer a cross-platform tool for processing amplicon data from various organisms in the context of metabarcoding studies.
Barnabé, Christian +5 more
doaj +1 more source
Advanced Science, EarlyView.A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen +15 more
wiley +1 more source
The novel genomic DNA integrity in neutral buffer formalin, Bouin’s fluid, and zinc formalin fixatives: A comparative study [PDF]
Iraqi Journal of Veterinary SciencesDNA extraction was successfully performed on all samples with variable concentrations. Fifteen liver samples were subjected to the extraction technique, with five liver samples utilized from each fixative, this comparison study aimed to assess DNA ...
Amani A. Alayash, Firas M. Abed
doaj +1 more source
A universal procedure for primer labelling of amplicons [PDF]
Nucleic Acids Research, 1997 Detection and visualisation of nucleic acids is integral to genome analyses. Exponential amplification procedures have provided the means for the manipulation of nucleic acid sequences, which were otherwise inaccessible. We describe the development and application of a universal method for the labelling of any PCR product using a single end-labelled ...
B A, Neilan, A N, Wilton, D, Jacobs
openaire +2 more sources
Supplementary Table S3.6. | Amplicon-Based NGS Data for Clinical Samples of Neisseria gonorrhoeae: antibiotic resistance genotype.NA – Not applicable; ; ; AZM – Azithromycin; CIP – Ciprofloxacin; PEN – Penicillin; SPT – Spectinomycin; TET – Tetracycline;
Carolina Fonseca (18364389)
core +1 more source
The methylation levels of STSs are displayed within amplicon A and amplicon B.
, 2013 (a,b)The overall methylation levels are displayed within amplicon A and amplicon B as box plots in SRTSs and NRTSs compared with normal controls.(c,d)The average methylation of the CpG units of amplicon A and amplicon B is presented for SRTSs, NRTS, and ...
Wen Jie Zhang (528978) +11 more
core +1 more source
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
Advanced Science, EarlyView.Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim +16 more
wiley +1 more source
A Panel of Circulating Exosomal sncRNAs Associated With Lung Cancer Risk up to 10 Years in Advance
Advanced Science, EarlyView.Lung cancer is often diagnosed too late, and current screening overlooks many people at risk. In a long‐term study of smokers, a panel of small non‐coding RNAs carried in blood exosomes signals elevated lung cancer risk up to ten years before diagnosis, pointing toward a blood‐based tool for earlier risk detection.
Zhuokun Feng +12 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source