Results 141 to 150 of about 165,809 (296)

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Resistant Peanut Genotype Reprograms Rhizosphere Metabolism to Enhance Bacterial Wilt Suppression

Advanced Science, EarlyView.
The resistant peanut genotype selectively recruits beneficial bacteria, which coincides with the activation of salicylic acid (SA)‐dependent systemic acquired resistance (SAR) against Ralstonia solanacearum. Keystone rhizosphere metabolites are positively correlated with both beneficial microbiome assembly and SAR gene expression.
Rui Ren, Xiaogang Li, Hao Li, Zenghui Cao, Mengtian Hou, Chunlei Zhao, Nan Lou, Sasa Hu, Yanzhe Li, Qian Ma, Yaoyao Li, Yi Fan, Kunkun Zhao, Kai Zhao, Ding Qiu, Fangping Gong, Zhongfeng Li, Haitao Liu, Xingli Ma, Xingxiang Wang, Dongmei Yin   +20 more
wiley   +1 more source

PCR and sequencing primers: List of PCR and sequencing primers with the expected length of each amplicon indicated.

, 2012
PCR and sequencing primers: List of PCR and sequencing primers with the expected length of each amplicon indicated.
Konrad Fiedler (118444), Patrick Strutzenberger (118435), Gunnar Brehm (118440)   +2 more
core   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

ARTIC RSV amplicon sequencing reveals global RSV genotype dynamics

This repository contains the consensus sequences generated for the study "ARTIC RSV amplicon sequencing reveals global RSV genotype dynamics". The fasta sequence headers are in the following format: > Seq_ID | Sequencing_run | Collection_year ...
Mateo, Carvajal, Weixler, Amelia, Guevara, Rommel, Wang, Xiong, Gabrial, Gonzalez, Carr, Michael, Fanning, Padraic M, History, Dewar, Rebecca, Sereewit, Jaydee, Nunley, B Ethan, Amelia, Weixler, Daniel, Hare, Pavitra, Roychoudhury, Tanmoy, Arif, Paúl, Cárdenas, Kunerth, Henry D, Namugenyi, Sarah, MRC Human Genetics Unit, Carlos, Fernandez Juan, Centre for Reproductive Health, Templeton, Kate, Carvajal, Mateo, Alex, Greninger, Sharma, Aryan, School of Neurological and Cardiovascular Sciences, Rebecca, Dewar, Jasim, Seema, Marshal, Louise, Royal (Dick) School of Veterinary Studies, Xie, Hong, Fries, Anthony C, O'Toole, Áine, Patrick, McClure, Cárdenas, Paúl, McClure, Patrick, School of Regeneration and Repair, Guy's and St Thomas' NHS Foundation Trust, Xiong, Wang, Loose, Matt, Maloney, Daniel, Universidad San Francisco de Quito, School of History, Classics and Archaeology, Fernandes, Goncalo, Meyer, Jennifer R, Fernandez, Juan Carlos, Greninger, Alex, School of Biological Sciences, NHS Lothian, Hare, Daniel, Rommel, Guevara, Nebbai, Gaia, Padraic, Fanning M, Benítez, Denisse, School of Population Health Sciences, Rambaut, Andrew, Gonzalez, Gabrial, Roychoudhury, Pavitra, Minnesota Department of Health, Senjuti, Saha, Lanter, Kelsey, University of Nottingham, Saha, Senjuti, Williams, Tom, Sarah, Namugenyi, University of Washington, Williams, Thomas, School of Informatics, University College Dublin   +68 more
core   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

16S rRNA amplicon sequencing of organic and conventional chickens

Microbiology Resource Announcements
ABSTRACT We report 16S rRNA sequencing of microbiomes associated with organic and conventional retail chickens ( n =31), processed via whole-carcass enrichment and rinse methodologies.
Anuradha J. Punchihewage-Don, Nur A. Hasan, Salina Parveen   +2 more
openaire   +2 more sources

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source