Results 31 to 40 of about 12,396 (213)
Monoconjugation of Human Amylin with Methylpolyethyleneglycol. [PDF]
PLoS ONE, 2015 Amylin is a pancreatic hormone cosecreted with insulin that exerts unique roles in metabolism and glucose homeostasis. The therapeutic restoration of postprandial and basal amylin levels is highly desirable in diabetes mellitus.
Tháyna Sisnande +7 more
doaj +1 more source
Differential effect of amylin on endothelial-dependent vasodilation in mesenteric arteries from control and insulin resistant rats. [PDF]
PLoS ONE, 2015 Insulin resistance (IR) is frequently associated with endothelial dysfunction and has been proposed to play a major role in cardiovascular disease (CVD). On the other hand, amylin has long been related to IR.
Mariam El Assar +6 more
doaj +1 more source
The satiating hormone amylin enhances neurogenesis in the area postrema of adult rats
Molecular Metabolism, 2016 Objective: Adult neurogenesis in the subgranular zone and subventricular zone is generally accepted, but its existence in other brain areas is still controversial.
Claudia G. Liberini +3 more
doaj +1 more source
European Journal of Neuroscience, 2021 The role of receptor activity‐modifying proteins (RAMPs) in modulating the pharmacological effects of an amylin receptor selective agonist (NN1213) or the dual amylin–calcitonin receptor agonist (DACRA), salmon calcitonin (sCT), was tested in three RAMP ...
S. Arrigoni +6 more
semanticscholar +1 more source
European Journal of Neuroscience, 2021 The pancreatic hormone amylin plays a central role in regulating energy homeostasis and glycaemic control by stimulating satiation and reducing food reward, making amylin receptor agonists attractive for the treatment of metabolic diseases.
Grethe Skovbjerg +9 more
semanticscholar +1 more source
Amylin receptor: a common pathophysiological target in Alzheimer’s Disease and Diabetes Mellitus
Frontiers in Aging Neuroscience, 2013 Amylin (islet amyloid polypeptide) and amyloid beta protein (Abeta), which are deposited within pancreatic islets of diabetics and brains of Alzheimer’s patients respectively, share many biophysical and physiological properties.
Wen eFu, Aarti ePatel, Jack H. Jhamandas
doaj +1 more source
Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils
bioRxiv, 2020 Human islet amyloid polypeptide (hIAPP) functions as a glucose-regulating hormone but deposits as amyloid fibrils in more than 90% of patients with type II diabetes (T2D). Here we report the cryo-EM structure of recombinant full-length hIAPP fibrils. The
Q. Cao +4 more
semanticscholar +1 more source
Circulating Differentially Methylated Amylin DNA as a Biomarker of β-Cell Loss in Type 1 Diabetes. [PDF]
PLoS ONE, 2016 In type 1 diabetes (T1D), β-cell loss is silent during disease progression. Methylation-sensitive quantitative real-time PCR (qPCR) of β-cell-derived DNA in the blood can serve as a biomarker of β-cell death in T1D.
John A Olsen +4 more
doaj +1 more source
Quantitative, High-Throughput Assays for Proteolytic Degradation of Amylin
Methods and Protocols, 2020 Amylin is a pancreatic peptide hormone that regulates glucose homeostasis but also aggregates to form islet amyloid in type-2 diabetes. Given its role in both health and disease, there is renewed interest in proteolytic degradation of amylin by insulin ...
Caitlin N. Suire +2 more
doaj +1 more source
Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele. [PDF]
PLoS ONE, 2014 Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features.
Wei Qiao Qiu +5 more
doaj +1 more source