Results 41 to 50 of about 12,396 (213)

Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases

Molecular Metabolism, 2020
Background Therapies for metabolic diseases are numerous, yet improving insulin sensitivity beyond that induced by weight loss remains challenging. Therefore, search continues for novel treatment candidates that can stimulate insulin sensitivity and ...
N. Sonne, M. Karsdal, K. Henriksen
semanticscholar   +1 more source

The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes with amyloid assays; Implications for inhibitor design.

PLoS ONE, 2019
The development of inhibitors of islet amyloid formation is important as pancreatic amyloid deposition contributes to type-2 diabetes and islet transplant failure.
Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh   +4 more
doaj   +1 more source

Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese. [PDF]

PLoS ONE, 2011
BACKGROUND: Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans ...
Xinwei Hou, Liang Sun, Zongmeng Li, Haiwei Mou, Zhijie Yu, Huaixing Li, Peizhen Jiang, Danxia Yu, Hongyu Wu, Xingwang Ye, Xu Lin, Yingying Le   +11 more
doaj   +1 more source

Amylin, Another Important Neuroendocrine Hormone for the Treatment of Diabesity

International Journal of Molecular Sciences
Diabetes mellitus is a devastating chronic metabolic disease. Since the majority of type 2 diabetes mellitus patients are overweight or obese, a novel term—diabesity—has emerged.
Stjepan Eržen, Gašper Tonin, Dubravka Jurišić Eržen, Jasna Klen   +3 more
semanticscholar   +1 more source

Correlations between endogen amylin hormone and some hormonal, biochemical and bone parameters in pullets

Brazilian Journal of Poultry Science, 2014
The objective of this study was to assess the correlations of amylin (a pancreatic polypeptide hormone) with some hormonal, biochemical and bone parameters in pullets. Forty 18-week-old pullets were used.
S Guzel, N Gunes
doaj   +1 more source

NN1213 – A Potent, Long-Acting, and Selective Analog of Human Amylin

Journal of Medicinal Chemistry
Amylin, a member of the calcitonin family, acts via amylin receptors in the hindbrain and hypothalamus to suppress appetite. Native ligands of these receptors are peptides with short half-lives.
Kirsten Dahl, Kirsten Raun, J. L. Hansen, Christian Poulsen, C. De La Cour, Trine Ryberg Clausen, Ann Maria Kruse Hansen, Linu M John, Annette Plesner, Gao Sun, Morten Schlein, R. B. Skyggebjerg, Thomas Kruse   +12 more
semanticscholar   +1 more source

Change of plasma amylin after bariatric surgery challenged by oral glucose is associated with remission of type 2 diabetes mellitus

Journal of the Chinese Medical Association, 2021
Background: Gastric bypass (GB) and sleeve gastrectomy (SG) were found to achieve different remission rates in the treatment of type 2 diabetes (T2DM).
Jiunn-Wei Wang, P. Chen, Hsien-Hao Huang, C. Yeh, Shu-Chun Chen, Wei-Jei Lee, Chih‐Yen Chen   +6 more
semanticscholar   +1 more source

Amylin: Localization, Effects on Cerebral Arteries and on Local Cerebral Blood Flow in the Cat

The Scientific World Journal, 2001
Amylin and adrenomedullin are two peptides structurally related to calcitonin gene-related peptide (CGRP). We studied the occurrence of amylin in trigeminal ganglia and cerebral blood vessels of the cat with immunocytochemistry and evaluated the role of ...
Lars Edvinsson, Peter J. Goadsby, Rolf Uddman   +2 more
doaj   +1 more source

Amylin induces hypoglycemia in mice

Anais da Academia Brasileira de Ciências, 2013
Amylin is a 37-aminoacid pancreatic protein that exerts control over several metabolic events such as glycemia and lacticemia. Amylin has long been shown to induce increases in arterial plasma glucose.
Luiz H. Guerreiro, Daniel DA Silva, Mauro Sola-Penna, Daniella M. Mizurini, Luís M.T.R. Lima   +4 more
doaj   +1 more source

Inhibition of human amylin aggregation by Flavonoid Chrysin: An in-silico and in-vitro approach

International Journal of Medical Sciences, 2021
Islet amyloid polypeptide (amylin), consecrated by the pancreatic β-cells with insulin, has a significant role to play in maintaining homeostasis of islet cell hormones. Alzheimer's disease is the predominant source of dementia.
Abdullah A. Alkahtane, Hamzah A. Alghamdi, B. Almutairi, M. Khan, Saquib Hasnain, Mohamed M. Abdel-Daim, Wadha M. Alghamdi, S. H. Alkahtani   +7 more
semanticscholar   +1 more source