Results 61 to 70 of about 12,396 (213)

Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice

Molecular Metabolism, 2020
Objective Amylin was found to regulate glucose and lipid metabolism by acting on the arcuate nucleus of the hypothalamus (ARC). Maternal high-fat diet (HFD) induces sex-specific metabolic diseases mediated by the ARC in offspring.
Cheng Li, Jingjing Xu, Hong-Tao Hu, Chao-Yi Shi, Chuan-jin Yu, J. Sheng, Yan-ting Wu, He-feng Huang   +7 more
semanticscholar   +1 more source

Mitochondrial Adaptations in Skeletal Muscle Following Incretin‐Based Therapies: In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Incretin‐based therapies such as glucagon‐like peptide‐1 receptor agonists (GLP‐1Ras), dual GLP‐1/GIP agonists and amylin analogues have demonstrated significant weight loss benefits. However, their impact on skeletal muscle mitochondrial function, particularly under metabolic stress, remains unclear. This study aimed to investigate
Victoria Old, Melanie Davies, Matthew Denniff, Pratik Choudhary, Nicholas Eastley, Robert U. Ashford, Emma Watson   +6 more
wiley   +1 more source

Structural Analysis of Amylin and Amyloid β Peptide Signaling in Alzheimer’s Disease

Biomolecules
Amylin and amyloid β belong to the same protein family and activate the same receptors. Amyloid β levels are elevated in Alzheimer’s disease. Recent studies have demonstrated that amylin-based peptides can reduce the symptoms of Alzheimer’s disease in ...
Longsheng Xie, Christopher Lockhart, Steven R. Bowers, Dmitri K. Klimov, Mohsin Saleet Jafri   +4 more
doaj   +1 more source

Central control of energy balance by amylin and calcitonin receptor agonists and their potential for treatment of metabolic diseases.

Basic & Clinical Pharmacology & Toxicology, 2020
The prevalence of obesity and associated comorbidities such as type 2 diabetes and cardiovascular disease are increasing globally. Body weight loss reduces the risk of morbidity and mortality in obese individuals and thus, pharmacotherapies that induce ...
H. Zakariassen, L. John, T. Lutz
semanticscholar   +1 more source

Toxic mechanisms of amyloid oligomers and therapeutic strategies

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Amyloid oligomers are increasingly recognized as the major toxic contributors across protein‐misfolding disorders. In this review, we cover mechanistic evidence showing how these transient and structurally heterogeneous oligomers disrupt cellular homeostasis by: (i) permeabilizing lipid membranes and forming ion‐conducting pores; (ii ...
Magdalena I. Ivanova, Carmelo La Rosa, Ayyalusamy Ramamoorthy   +2 more
wiley   +1 more source

Molecular Mechanisms of Protein–Lipid Interactions and Protein Folding of Heterogeneous Amylin and Tau Oligomers on Lipid Nanodomains That Link to Alzheimer’s

Macromol, 2023
The disruption of cell membranes by tau and amylin oligomers is linked to amyloid diseases such as Alzheimer’s and diabetes, respectively. The recent studies suggest that misfolded tau and amylin can form neurotoxic hetero-oligomers that are structurally
Natalia Santos, Luthary Segura, Amber Lewis, Thuong Pham, Kwan H. Cheng   +4 more
doaj   +1 more source

The Calcitonin Receptor Plays a Major Role in Glucose Regulation as a Function of Dual Amylin and Calcitonin Receptor Agonist Therapy

Journal of Pharmacology and Experimental Therapeutics, 2020
Amylin treatment improves body weight and glucose control, although it is limited by a short action and need for high doses. Dual amylin and calcitonin receptor agonists (DACRAs) are dual amylin and calcitonin receptor agonists with beneficial effects ...
A. T. Larsen, N. Sonne, K. Andreassen, M. Karsdal, K. Henriksen   +4 more
semanticscholar   +1 more source

Hypoglycemia attenuates acute amylin-induced reduction of food intake in male rats.

Physiology and Behavior, 2021
The ability of amylin to inhibit gastric emptying and glucagon secretion in rats is reduced under hypoglycemic conditions. These effects are considered part of a fail-safe mechanism that prevents amylin from further decreasing nutrient supply when blood ...
Miriam Honegger, T. Lutz, C. Boyle
semanticscholar   +1 more source

Structural and morphological dynamics of “on‐path” and “off‐path” oligomers of human islet amyloid polypeptide

Protein Science, Volume 35, Issue 4, April 2026.
Abstract The deposition of cytotoxic human islet amyloid polypeptide (IAPP) aggregates is a hallmark feature of Type 2 Diabetes. However, the structural evolution and cytotoxicity of IAPP aggregate species remain poorly understood. This study combines kinetics, biophysical and cell assays to resolve the morphological dynamics of IAPP aggregation. Using
Daniel Warren, Jadon Sitton, Dmitry Kurouski   +2 more
wiley   +1 more source

Amylin and its Analogs: A Friend or Foe for the Treatment of Alzheimer’s Disease?

Frontiers in Aging Neuroscience, 2014
Amylin, a gut-brain axis hormone, and amyloid-beta peptides (Aβ), a major component of the Alzheimer’s disease (AD) brain, share several features, including similar β-sheet secondary structures, binding to the same receptor and being degraded by the same
Wei Qiao (Wendy) eQiu, Haihao eZhu
doaj   +1 more source