Results 51 to 60 of about 11,568,194 (143)

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels [PDF]

, 2013
The objective of this study was to investigate the effects of modulating brain amyloid-b (Ab) levels at different stages of amyloid pathology on synaptic function, inflammatory cell changes and hippocampal neurogenesis, i.e.
Nordberg, A,, Carina M Thomé, Greig, NH, Greig, Nigel H, Thomé, Carina M, Anna M Lilja, Marutle, Amelia, Daniel Gonzalez, Gonzalez, D, Marutle, A,, Lilja, AM, Amelia Marutle, Röjdner, Jennie, Gonzalez, Daniel, Rojdner, J, Elisa Storelli, Storelli, E, Jennie Röjdner, Unger-Lithner, C, Nordberg, Agneta, Tamanna Mustafiz, Mustafiz, T,, Christina Unger-Lithner, Nigel H Greig, Thome, CM, Mustafiz, Tamanna, Lilja, Anna M, Unger-Lithner, Christina, Storelli, Elisa, Agneta Nordberg, Röjdner Jennie, Mustafiz Tamanna, Marutle Amelia, Thomé Carina M., Gonzalez Daniel, Nordberg Agneta, Lilja Anna M., Greig Nigel H., Storelli Elisa, Unger-Lithner Christina   +39 more
core   +2 more sources

Mitochondrial β-amyloid in Alzheimer's disease [PDF]

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway, Borger, Eva; id_orcid, Ainge, James Alexander; id_orcid, Aitken, Laura; id_orcid, Gunn-Moore, Frank J; id_orcid   +23 more
core   +1 more source

Diagnosis, pathomechanisms and therapy of cerebral amyloid angiopathy-related inflammation (CAA-ri)

Neurological Research and Practice
Background Research of the past years has refined our perception of cerebral amyloid angiopathy-related inflammation (CAA-ri) as a subacute autoimmune encephalopathy, which is presumably caused by elevated CSF concentrations of anti-amyloid β (Aβ ...
Rebecca M. Seifert, Randolf Klingebiel, Wolf-Rüdiger Schäbitz   +2 more
doaj   +1 more source

Plasma Biomarkers for Cerebral Amyloid Angiopathy and Implications for Amyloid-Related Imaging Abnormalities: A Comprehensive Review. [PDF]

J Clin Med
Anti-amyloid therapies (AATs) are increasingly being recognized as promising treatment options for Alzheimer's disease (AD). Amyloid-related imaging abnormalities (ARIAs), small areas of edema and microbleeds in the brain presenting as abnormal signals ...
Sin MK, Dage JL, Nho K, Dowling NM, Seyfried NT, Bennett DA, Levey AI, Ahmed A.   +7 more
europepmc   +2 more sources

Multimodal Imaging Findings of Cerebral Amyloid Angiopathy Related Inflammation With Unusual Clinical Manifestation: A Case Report [PDF]

, 2023
Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare encephalopathy characterized by the coexistence of a perivascular inflammatory reaction in patients with cerebral amyloid angiopathy.
서상현, 유영훈, 이재훈, 주비오, 유한수, 안성준, 박미나   +6 more
core   +1 more source

Amyloid‐related imaging abnormalities (ARIA): diagnosis, management, and care in the setting of amyloid‐modifying therapy

Annals of Clinical and Translational Neurology
Amyloid‐related imaging abnormalities, were originally described by dementia care experts. The wider use of aducanumab and now lecanemab warrant broader understanding by the health care provider continuum.
Rade B. Vukmir
doaj   +1 more source

Amyloid‐Related Imaging Abnormality (ARIA) Beyond the APOE‐ε4 Allele

Chronic Diseases and Translational Medicine
Monoclonal antibodies (mAbs) have made significant progress in the treatment of Alzheimer's disease (AD). However, mAbs are associated with adverse effects, including Amyloid‐Related Imaging Abnormality (ARIA), which manifests as edema or effusion (ARIA ...
Valentinus Besin, Farizky Martriano Humardani, Fenny Lanawati Yudiarto, Paulus Anam Ong, Sulistyo Emantoko Dwi Putra, Ratih Asmana Ningrum   +5 more
doaj   +1 more source

Anti-Aβ autoantibodies in amyloid related imaging abnormalities (ARIA): candidate biomarker for immunotherapy in Alzheimer’s disease and cerebral amyloid angiopathy.

Frontiers in Neurology, 2015
Amyloid Related Imaging Abnormalities (ARIA) represent the major severe side effect of amyloid-beta (Aβ) immunotherapy for Alzheimer’s disease (AD).
Jacopo C. DiFrancesco, Jacopo C. DiFrancesco, Martina eLongoni, Martina eLongoni, Fabrizio ePiazza, Fabrizio ePiazza, Fabrizio ePiazza   +6 more
doaj   +1 more source

Interim analysis of all-case post-marketing surveillance study in Japan: lecanemab in patients with early Alzheimer’s disease

The Journal of Prevention of Alzheimer's Disease
Background: Lecanemab is a monoclonal antibody targeting amyloid-beta protofibrils, indicated for patients with mild cognitive impairment (MCI) and mild dementia due to Alzheimer’s disease.
Atsushi Iwata, Yukinori Sakata, Kinuyo Koizumi, Akira Endo, Weijie Kuang, Kenta Sumitomo, Mika Ishii   +6 more
doaj   +1 more source

Sex and APOE ε4 genotype modify risk factor associations with cerebral amyloid angiopathy: a multi-cohort autopsy study

Alzheimer’s Research & Therapy
Background This study aimed to identify risk factors and develop statistical models to predict cerebral amyloid angiopathy (CAA). Methods Associations between demographic, cognition, cardiovascular, and AD-related neuropathology and CAA were analyzed ...
Liwei Ma, Yihan Wang, Benjamin Goudey, Liang Jin, Yijun Pan   +4 more
doaj   +1 more source