Results 71 to 80 of about 11,568,194 (143)

Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives

Translational Neurodegeneration
Alzheimer’s disease (AD) is the most common type of dementia. Monoclonal antibodies (MABs) serve as a promising therapeutic approach for AD by selectively targeting key pathogenic factors, such as amyloid-β (Aβ) peptide, tau protein, and ...
Byeong-Hyeon Kim, Sujin Kim, Yunkwon Nam, Yong Ho Park, Seong Min Shin, Minho Moon   +5 more
doaj   +1 more source

The role of neuroinflammation in cerebral amyloid angiopathy

EBioMedicine
Summary: Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease characterized by vascular amyloid-β (Aβ) deposition. CAA is often seen in the brains of elderly individuals and in a majority of patients with Alzheimer's disease.
Hilde van den Brink, Sabine Voigt, Mariel Kozberg, Ellis S. van Etten   +3 more
doaj   +1 more source

Thermodynamic impedance mismatch in neurodegeneration: A biophysical framework for the prediction of amyloid-related imaging abnormalities

Amyloid-related imaging abnormalities (ARIA) represent a significant iatrogenic complication of anti-amyloid monoclonal antibody therapies.
Kevin Thorsen Baird
core   +1 more source

Alzheimer's Disease Anti-Amyloid Immunotherapies: Imaging Recommendations and Practice Considerations for ARIA Monitoring [PDF]

With the full FDA approval and centers for Medicare & Medicaid services (CMS) coverage of lecanemab and donanemab, a growing number of practices are offering anti-amyloid immunotherapy to appropriate patients with cognitive impairment (MCI) or mild ...
Barakos, Jerome A, Benayoun, Marc Daniel, Poussaint, Tina Young, Raji, Cyrus A, Ramanan, Vijay K, Tanabe, Jody, Chiang, Gloria C, Jack, Clifford R, Pillai, Jay J, Yu, Fang F, ASNR Alzheimer’s, ARIA, and Dementia Study Group, Zaharchuk, Greg, Zeinah, Michael, Whitlow, Christopher T, Tanenbaum, Lawrence, Franceschi, Ana M, Andrews, Trevor J, Bash, Suzie, Benzinger, Tammie S, Barkhof, Frederik, Cogswell, Petrice M   +20 more
core   +1 more source

Validation of an MRI Rating Scale for Amyloid-Related Imaging Abnormalities [PDF]

, 2017
INTRODUCTION: Immunotherapeutic agents against amyloid beta (Aβ) are associated with adverse events, including amyloid-related imaging abnormalities with edema and effusion (ARIA-E). Recently, a magnetic resonance imaging (MRI) rating scale was developed
Bechten, A, Daams, M, Brashear, HR, Arrighi, HM, Barkhof, F, Wattjes, MP, Aliaga, ES, Purcell, DD   +7 more
core  

Anti-amyloid-β monoclonal antibody for Alzheimer's disease: value, clinical practice and challenges

Chinese Journal of Contemporary Neurology and Neurosurgery
The success of anti-amyloid-β (Aβ) monoclonal antibody has marked the beginning of the disease-modifying therapy (DMT) era for Alzheimer's disease (AD). As these agents are increasingly adopted in clinical practice, the focus of management has gradually ...
WANG Gang, GENG Jie-li
doaj   +1 more source

The value of subtraction MRI in detection of amyloid-related imaging abnormalities with oedema or effusion in Alzheimer's patients: An interobserver study [PDF]

, 2017
BACKGROUND: Immunotherapeutic treatments targeting amyloid-β plaques in Alzheimer's disease (AD) are associated with the presence of amyloid-related imaging abnormalities with oedema or effusion (ARIA-E), whose detection and classification is crucial to ...
Ingala, S, Sanchez, E, Martens, RM, van Schijndel, RA, Machado, VB, Bechten, A, Purcell, D, de Jong, MC, Barkhof, F, Wattjes, MP, Brashear, RH, Arrighi, MH   +11 more
core   +1 more source

The Association Between Retinal Vasculopathy and Retinal Amyloid-Beta Accumulation

, 2020
Patients with Alzheimer\u27s disease (AD)-related cognitive disorders exhibit retinal and choroidal vascular abnormalities and intraretinal accumulation of Aβ plaque. Modern retinal imaging modalities to quantify retinal vasculopathy and amyloid-beta (Aβ)
Oana M. Dumitrascu; Maziyar Khansari; Yonggang Shi; Julia Sheyn; Patrick Lyden; Steven Verdooner; Keith Black; Yosef Koronyo; Maya Koronyo-Hamaoui
core  

Image_1_Risk factors in developing amyloid related imaging abnormalities (ARIA) and clinical implications.TIF

Alzheimer’s disease (AD) affects over 6 million people over the age of 65. The advent of new anti-amyloid monoclonal antibodies as treatment for early Alzheimer’s disease these immunotherapeutics may slow disease progression but also pose significant ...
Sarah J. Doran (17812700), Russell P. Sawyer (17812703)   +1 more
core   +1 more source

A regional framework for the detection and management of ARIA with anti-amyloid therapies in early Alzheimer’s disease in Asia

The Journal of Prevention of Alzheimer's Disease
Alzheimer’s disease (AD) is a growing public health concern in Asia, with an increasing prevalence driven by demographic shifts and rising life expectancy.
So Young Moon, Ta-Fu Chen, Bo-Ching Lee, Won Jin Moon, Nagaendran Kandiah, Sumeet Kumar, Young Ho Park, Kaori Inaba, Amitabh Dash   +8 more
doaj   +1 more source