Results 31 to 40 of about 11,332,305 (264)

Case report and risk factor analysis of amyloid-related imaging abnormalities induced by lecanemab in Alzheimer's disease [PDF]

Zhenduanxue lilun yu shijian
Amyloid-related imaging abnormalities (ARIA) represent a significant safety concern that requires attention during the treatment of Alzheimer's disease (AD) with lecanemab, and their occurrence is associated with multiple factors.
XU Chenhaoyi, LIU Jingwen, FANG Min
doaj   +1 more source

Amyloid-Related Imaging Abnormalities With Anti-amyloid Antibodies for the Treatment of Dementia Due to Alzheimer's Disease

Frontiers in Neurology, 2022
Second-generation anti-amyloid monoclonal antibodies are emerging as a viable therapeutic option for individuals with prodromal and mild dementia due to Alzheimer's disease (AD).
Charles G. Withington, R. Scott Turner
doaj   +1 more source

Spontaneous amyloid-related imaging abnormalities in a cognitively normal adult [PDF]

Neurology, 2014
An 81-year-old cognitively normal man ( APOE e3/e3) without risk factors had amyloid-related imaging abnormalities with sulcal effusions and edema (ARIA-E), siderosis, and microhemorrhages (ARIA-H) on MRI (figure 1).1 He was identified from 1,006 participants followed with 3,385 MRIs in 2010–2013 in Alzheimer's Disease Neuroimaging Initiative (ADNI) 2 ...
Mekala R, Raman, Heather J, Wiste, Matthew L, Senjem, Chadwick P, Ward, Clifford R, Jack, Kejal, Kantarci   +5 more
openaire   +2 more sources

An MRI Rating Scale for Amyloid-Related Imaging Abnormalities with Edema or Effusion [PDF]

American Journal of Neuroradiology, 2013
Immune therapy against amyloid-β appears to be a promising target in Alzheimer disease. However, a dose-related risk for ARIA on FLAIR images thought to represent parenchymal vasogenic edema or sulcal effusion (termed "ARIA-E"), has been observed in clinical trials.
Barkhof, F., Daams, M., Scheltens, P., Brashear, H.R., Arrighi, H.M., Bechten, A.K., Morris, K., McGovern, M., Wattjes, M.P.   +8 more
openaire   +3 more sources

Artificial Intelligence-Assisted Detection of Amyloid-Related Imaging Abnormalities: Promise and Pitfalls. [PDF]

AJNR Am J Neuroradiol
The advent of anti-amyloid therapies (AATs) for Alzheimer disease (AD) has elevated the importance of MRI surveillance for amyloid-related imaging abnormalities (ARIA) such as microhemorrhages and siderosis (ARIA-H) and edema (ARIA-E). We report a literature review and early quality-assurance experience with an FDA-cleared decision support artificial ...
Petrella JR, Liu AJ, Wang LA, Doraiswamy PM.   +3 more
europepmc   +3 more sources

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [PDF]

, 2010
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss.
Fuhrmann Martin, Kretzschmar Hans, Ochs, Simon M., Herms Jochen, Simon M Ochs, Burgold Steffen, Jochen Herms, Frank M LaFerla, Burgold, Steffen, Herms, Jochen, Hans Kretzschmar, Gerda Mitteregger, Fuhrmann, Martin, Kretzschmar, Hans, Ochs Simon M., Frank M. Laferla, LaFerla Frank M., Hoffmann, Nadine, LaFerla, Frank M., Bittner, Tobias, Bittner Tobias, Mitteregger, Gerda, Nadine Hoffmann, Simon M. Ochs, Martin Fuhrmann, Tobias Bittner, Hoffmann Nadine, Steffen Burgold, Mitteregger Gerda   +28 more
core   +2 more sources

Characterization of amyloid‐related imaging abnormality in the DIAN‐TU‐001 trial [PDF]

Alzheimer's & Dementia, 2021
AbstractBackgroundAmyloid‐related imaging abnormalities (ARIA), edema (E) or hemorrhagic (H) type, have been reported in trials of anti‐β‐amyloid passive immunotherapies in sporadic and dominantly inherited Alzheimer Disease (DIAD). However, beyond APOE‐ɛ4 the risk factors and clinical implications of ARIA are not well understood, especially in DIAD ...
Nelly Joseph‐Mathurin, Jorge J Llibre‐Guerra, Austin A. McCullough, Yan Li, Carsten Hofmann, Jakub Wojtowicz, Qing Wang, Guoqiao Wang, Brian A. Gordon, Charles D. Chen, William S. Brooks, Serge Gauthier, Karen C. Holdridge, Ging‐Yuek Robin Hsiung, Clifford R. Jack, Gregory Klein, Mario Masellis, Catherine J. Mummery, Gregory M. Preboske, Anna Santacruz, David Wallon, Chengjie Xiong, Roy Yaari, Eric McDade, Randall J. Bateman, Stephen P. Salloway, Tammie L.S. Benzinger, David B. Clifford   +27 more
openaire   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Diffusion imaging shows abnormalities after blunt head trauma when conventional magnetic resonance imaging is normal [PDF]

, 2001
The investigation and management of patients after head injury must include the accurate and complete identification of cerebral damage. Using diffusion tensor imaging, abnormalities of diffusion in patients with head injuries and unremarkable MRI have ...
F J Rugg-Gunn, DUNCAN, JS, Duncan, J.S., SYMMS, MR, RUGG-GUNN, FJ, Barker, Gareth; id_orcid, GREENWOOD, R, Barker, G.J., Greenwood, R., Symms, M.J., Rugg-Gunn, F.J.   +10 more
core   +1 more source

Vessels Sing Their ARIAs: The Role of Vascular Amyloid in the Age of Aducanumab

, 2022
We review the implications of the recently approved aducanumab amyloid-β immunotherapy for treating Alzheimer disease with comorbid cerebral amyloid angiopathy.
Sveikata, Lukas, Viswanathan, Anand, Charidimou, Andreas, Andreas Charidimou, Anand Viswanathan, Lukas Sveikata   +5 more
core   +1 more source