Results 31 to 40 of about 10,843,123 (260)

Safety, tolerability, immunogenicity, and efficacy of UB-311 in participants with mild Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 2a studyResearch in context

EBioMedicine, 2023
Summary: Background: Anti-amyloid vaccines may offer a convenient, affordable, and accessible means of preventing and treating Alzheimer's disease. UB-311 is an anti–amyloid-β active immunotherapeutic vaccine shown to be well-tolerated and to have a ...
Hui Jing Yu, Samuel P. Dickson, Pei-Ning Wang, Ming-Jang Chiu, Chin-Chang Huang, Chiung-Chih Chang, Hope Liu, Suzanne B. Hendrix, Jean-Cosme Dodart, Ajay Verma, Chang Yi Wang, Jeffrey Cummings   +11 more
doaj   +1 more source

Aducanumab-Related Amyloid-Related Imaging Abnormalities

Clinical Nuclear Medicine, 2022
Abstract When the FDA granted accelerated approval of Biogen's Alzheimer disease drug, aducanumab (marketed as Aduhelm), it deviated from its mission of guaranteeing drug safety and efficacy because the approval was based exclusively on a perceived dose-dependent reduction in brain amyloid deposits and not upon a proven clinical effect.
Høilund-Carlsen, Poul F., Werner, Thomas J., Alavi, Abass, Revheim, Mona Elisabeth   +3 more
openaire   +3 more sources

MR Imaging Features of Amyloid-Related Imaging Abnormalities [PDF]

American Journal of Neuroradiology, 2013
AD is one of the few leading causes of death without a disease-modifying drug; however, hopeful agents are in various phases of development. MR imaging abnormalities, collectively referred to as amyloid-related imaging abnormalities, have been reported for several agents that target cerebral Aβ burden.
J, Barakos, R, Sperling, S, Salloway, C, Jack, A, Gass, J B, Fiebach, D, Tampieri, D, Melançon, Y, Miaux, G, Rippon, R, Black, Y, Lu, H R, Brashear, H M, Arrighi, K A, Morris, M, Grundman   +15 more
openaire   +2 more sources

Subcortical signal alteration of corticospinal tracts. A radiologic manifestation of ARIA: A case report

Radiology Case Reports, 2023
Patients with Alzheimer's disease who have been given monoclonal antibodies targeting amyloid-β (Aβ) (eg, gantenerumab, donanemab, lecanemab, and aducanumab) for scientific purposes may have a spectrum of imaging findings known as amyloid-related imaging
Houman Sotoudeh, MD, Mohammadreza Alizadeh, MD, Ramin Shahidi, MD, Parnian Shobeiri, MD, MPH, Natelson love, MD, Aparna Singhal, MD   +5 more
doaj   +1 more source

Cerebral Amyloid Angiopathy: Emerging Concepts [PDF]

Journal of Stroke, 2015
Cerebral amyloid angiopathy (CAA) involves cerebrovascular amyloid deposition and is classified into several types according to the amyloid protein involved.
Masahito Yamada
doaj   +1 more source

Amyloid and tau PET in cerebral amyloid angiopathy-related inflammation two case reports and literature review

Frontiers in Neurology, 2023
BackgroundCerebral amyloid angiopathy-related inflammation (CAA-ri) is a clinical syndrome characterized by MRI findings of amyloid-related imaging abnormalities-edema (ARIA-E) suggestive of autoimmune and inflammatory reaction and hemorrhagic evidence ...
Jhih-Yong Yang, Yung-Tsai Chu, Hsin-Hsi Tsai, Hsin-Hsi Tsai, Jiann-Shing Jeng   +4 more
doaj   +1 more source

Case report and risk factor analysis of amyloid-related imaging abnormalities induced by lecanemab in Alzheimer's disease [PDF]

Zhenduanxue lilun yu shijian
Amyloid-related imaging abnormalities (ARIA) represent a significant safety concern that requires attention during the treatment of Alzheimer's disease (AD) with lecanemab, and their occurrence is associated with multiple factors.
XU Chenhaoyi, LIU Jingwen, FANG Min
doaj   +1 more source

Multiple events lead to dendritic spine loss in triple transgenic Alzheimer's disease mice [PDF]

, 2010
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) peptide, hyperphosphorylated tau protein, neuronal death, and synaptic loss.
Fuhrmann Martin, Kretzschmar Hans, Ochs, Simon M., Herms Jochen, Simon M Ochs, Burgold Steffen, Jochen Herms, Frank M LaFerla, Burgold, Steffen, Herms, Jochen, Hans Kretzschmar, Gerda Mitteregger, Fuhrmann, Martin, Kretzschmar, Hans, Ochs Simon M., Frank M. Laferla, LaFerla Frank M., Hoffmann, Nadine, LaFerla, Frank M., Bittner, Tobias, Bittner Tobias, Mitteregger, Gerda, Nadine Hoffmann, Simon M. Ochs, Martin Fuhrmann, Tobias Bittner, Hoffmann Nadine, Steffen Burgold, Mitteregger Gerda   +28 more
core   +2 more sources

Spontaneous amyloid-related imaging abnormalities in a cognitively normal adult [PDF]

Neurology, 2014
An 81-year-old cognitively normal man ( APOE e3/e3) without risk factors had amyloid-related imaging abnormalities with sulcal effusions and edema (ARIA-E), siderosis, and microhemorrhages (ARIA-H) on MRI (figure 1).1 He was identified from 1,006 participants followed with 3,385 MRIs in 2010–2013 in Alzheimer's Disease Neuroimaging Initiative (ADNI) 2 ...
Mekala R, Raman, Heather J, Wiste, Matthew L, Senjem, Chadwick P, Ward, Clifford R, Jack, Kejal, Kantarci   +5 more
openaire   +2 more sources

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source