Results 41 to 50 of about 10,843,123 (260)

A fluorescent amyloid sensor for quantitative super-resolution imaging of amyloid fibril assembly. [PDF]

, 2021
Many soluble proteins can self-assemble into macromolecular structures called amyloids, a subset of which are implicated in a range of neurodegenerative disorders.
Liam D., Adair, Amandeep, Kaur, Elizabeth J. , New, Margaret , Sunde, Sarah R., Ball   +4 more
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An MRI Rating Scale for Amyloid-Related Imaging Abnormalities with Edema or Effusion [PDF]

American Journal of Neuroradiology, 2013
Immune therapy against amyloid-β appears to be a promising target in Alzheimer disease. However, a dose-related risk for ARIA on FLAIR images thought to represent parenchymal vasogenic edema or sulcal effusion (termed "ARIA-E"), has been observed in clinical trials.
Barkhof, F., Daams, M., Scheltens, P., Brashear, H.R., Arrighi, H.M., Bechten, A.K., Morris, K., McGovern, M., Wattjes, M.P.   +8 more
openaire   +3 more sources

Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease [PDF]

, 2008
The deposition of the amyloid β-protein (Aβ) is one of the pathological hallmarks of Alzheimer's disease (AD). Aβ-deposits show the morphology of senile plaques and cerebral amyloid angiopathy (CAA). Senile plaques and vascular Aβ-deposits occur first in
Griffin, W. Sue T., Braak, Heiko, Thal, Dietmar Rudolf   +2 more
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Characterization of amyloid‐related imaging abnormality in the DIAN‐TU‐001 trial [PDF]

Alzheimer's & Dementia, 2021
AbstractBackgroundAmyloid‐related imaging abnormalities (ARIA), edema (E) or hemorrhagic (H) type, have been reported in trials of anti‐β‐amyloid passive immunotherapies in sporadic and dominantly inherited Alzheimer Disease (DIAD). However, beyond APOE‐ɛ4 the risk factors and clinical implications of ARIA are not well understood, especially in DIAD ...
Nelly Joseph‐Mathurin, Jorge J Llibre‐Guerra, Austin A. McCullough, Yan Li, Carsten Hofmann, Jakub Wojtowicz, Qing Wang, Guoqiao Wang, Brian A. Gordon, Charles D. Chen, William S. Brooks, Serge Gauthier, Karen C. Holdridge, Ging‐Yuek Robin Hsiung, Clifford R. Jack, Gregory Klein, Mario Masellis, Catherine J. Mummery, Gregory M. Preboske, Anna Santacruz, David Wallon, Chengjie Xiong, Roy Yaari, Eric McDade, Randall J. Bateman, Stephen P. Salloway, Tammie L.S. Benzinger, David B. Clifford   +27 more
openaire   +1 more source

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis [PDF]

, 2013
Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer’s disease (AD). AD is a complex disorder, characterised by several pathological features. The problem
Rafael Delgado Y Palacios, Christian Bigot, Van Der Linden, Anne-Marie, Bigot, Christian, Van der Linden, Annemie, Rafael Delgado y Palacios (498616), Verhoye, Marleen, Disha Shah, Annemie Van der Linden, Christian Bigot (498617), Dany V D'Souza, Shah, Disha, Disha Shah (498613), Annemie Van der Linden (2227165), Elisabeth Jonckers, D'Souza, Dany V., Greetje Vanhoutte, Jonckers, Elisabeth, Jelle Praet (498614), Delgado y Palacios, Rafael, Greetje Vanhoutte (498615), Marleen Verhoye, Praet, Jelle, Marleen Verhoye (95635), Vanhoutte, Greetje, Jelle Praet, Elisabeth Jonckers (353117), Dany V. D’Souza (498618)   +27 more
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Regulation of the metabolism of the Alzheimer's amyloid precursor protein by contactin 5 and BIN1 [PDF]

, 2012
Alzheimer’s disease (AD) is a progressive form of dementia, which currently has no cure. The metabolism of the amyloid precursor protein (APP) is an important determinant in the development of AD.
Glennon, Elizabeth Bernadette Claire
core   +6 more sources

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels [PDF]

, 2013
The objective of this study was to investigate the effects of modulating brain amyloid-b (Ab) levels at different stages of amyloid pathology on synaptic function, inflammatory cell changes and hippocampal neurogenesis, i.e.
Nordberg, A,, Carina M Thomé, Greig, NH, Greig, Nigel H, Thomé, Carina M, Anna M Lilja, Marutle, Amelia, Daniel Gonzalez, Gonzalez, D, Marutle, A,, Lilja, AM, Amelia Marutle, Röjdner, Jennie, Gonzalez, Daniel, Rojdner, J, Elisa Storelli, Storelli, E, Jennie Röjdner, Unger-Lithner, C, Nordberg, Agneta, Tamanna Mustafiz, Mustafiz, T,, Christina Unger-Lithner, Nigel H Greig, Thome, CM, Mustafiz, Tamanna, Lilja, Anna M, Unger-Lithner, Christina, Storelli, Elisa, Agneta Nordberg   +29 more
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Diffusion imaging shows abnormalities after blunt head trauma when conventional magnetic resonance imaging is normal [PDF]

, 2001
The investigation and management of patients after head injury must include the accurate and complete identification of cerebral damage. Using diffusion tensor imaging, abnormalities of diffusion in patients with head injuries and unremarkable MRI have ...
F J Rugg-Gunn, DUNCAN, JS, Duncan, J.S., SYMMS, MR, RUGG-GUNN, FJ, Barker, Gareth; id_orcid, GREENWOOD, R, Barker, G.J., Greenwood, R., Symms, M.J., Rugg-Gunn, F.J.   +10 more
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Insular volume abnormalities associated with different transition probabilities to psychosis [PDF]

, 2011
Background Although individuals vulnerable to psychosis show brain volumetric abnormalities, structural alterations underlying different probabilities for later transition are unknown.
McGuire, P., A. Riecher-Rössler, Simon, A., Simon, A, P. Fusar-Poli, Lenz, C., Fusar-Poli P., Riecher-Rössler, A., Bendfeldt, K, Stieglitz, R D, Riecher-Rössler, A, S. J. Borgwardt, McGuire, P, Borgwardt, S. J., J. Aston, Smieskova R., Bendfeldt K., Lenz C., Smieskova, R., Borgwardt, S J, Riecher-Rossler A., R. Smieskova, Riecher-Roessler, A., P. McGuire, Fusar-Poli, P, Simon A., A. Simon, Borgwardt S. J., K. Bendfeldt, Aston, J, Bendfeldt, K., Stieglitz, R. -D., Lenz, C, Stieglitz R. -D., Stieglitz, R.-D., R.-D. Stieglitz, Fusar-Poli, P., Aston J., McGuire P., Fusar-Poli, P.; id_orcid, Smieskova, R, C. Lenz, Aston, J.   +42 more
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Mitochondrial β-amyloid in Alzheimer's disease [PDF]

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Conway, SJ, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway   +20 more
core   +1 more source