Results 161 to 170 of about 516,976 (376)
Mechanochemistry: Fundamental Principles and Applications
Advanced Science, EarlyView.In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong +4 more
wiley +1 more source
Statistical Mechanics and Kinetics of Amyloid Fibrillation
, 2016 Amyloid fibrillation is a protein self-assembly phenomenon that is intimately related to well-known human neurodegenerative diseases. During the past few decades, striking advances have been achieved in our understanding of the physical origin of this ...
Hong, Liu, Huang, Ya Jing, Lee, Chiu Fan
core +1 more source
Advanced Science, EarlyView.In situ Cell‐type‐specific proteome Analysis using antibody‐mediated Biotinylation (iCAB) is a method that directly targets and analyzes proteins in specific cell types within tissue. Applied to 5xFAD mice, iCAB identifies ≈8000 cell‐type‐specific proteins, revealing unique pathways in neurons, astrocytes, and microglia.
Taekyung Ryu +6 more
wiley +1 more source
The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth [PDF]
arXiv, 2019 Many proteins have the potential to aggregate into amyloid fibrils, which are associated with a wide range of human disorders including Alzheimer's and Parkinson's disease. In contrast to that of folded proteins, the thermodynamic stability of amyloid fibrils is not well understood: specifically the balance between entropic and enthalpic terms ...
arxiv
Study of cosolvent-induced α-chymotrypsin fibrillogenesis: Does protein surface hydrophobicity trigger early stages of aggregation reaction? [PDF]
The misfolding of specific proteins is often associated with their assembly into fibrillar aggregates, commonly termed amyloid fibrils. Despite the many efforts expended to characterize amyloid formation in vitro, there is no deep knowledge about the ...
A Ahmad +66 more
core +1 more source
Advanced Science, EarlyView.BF‐PVA porous film is prepared by doping BF into PVA to form hydrogel and then freeze‐drying and compression to improve the tensile resistance, bending resistance, swelling resistance, degradation time and electrical properties of PVA. Finally, the degradable triboelectric sensor made of BF‐PVA porous film and Mg film is used to realize the signal ...
Yichang Quan +11 more
wiley +1 more source
Deposition of amyloid in the gastrointestinal tract. [PDF]
, 1969 Tuvia Gilat, M Revach, E Sohar
openalex +1 more source
Advanced Science, EarlyView.By studying the maturation mechanisms of vasopressin (AVP), this manuscript identifies FAM134B‐mediated ER‐phagy as a critical pathway for degrading both aggregated proAVP and the key ERAD component, HRD1. HRD1 induction mitigates proAVP aggregation and support AVP neuron function in the absence of autophagy.
Xuya Pan +16 more
wiley +1 more source
AMYLOID. VI. A COMPARISON OF TWO MORPHOLOGIC COMPONENTS OF HUMAN AMYLOID DEPOSITS [PDF]
, 1968 G. G. Glenner +7 more
openalex +1 more source
Advanced Science, EarlyView.Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du +8 more
wiley +1 more source