Results 161 to 170 of about 514,761 (295)
A Food and Drug Administration-approved Asthma Therapeutic Agent Impacts Amyloid β in the Brain in a Transgenic Model of Alzheimer Disease [PDF]
, 2014 Yukiko Hori +9 more
openalex +1 more source
Advanced Science, EarlyView.CRB‐2131, as a novel Nox inhibitor, suppresses brain oxidation, tauopathy, and neuro‐inflammation, thereby preventing death of mature neurons and promoting regeneration of immature neurons. Ultimately, this fosters a resilient brain and protects cognition.
Jihyeon Lee +13 more
wiley +1 more source
Plasmacytoma of the Sternum with Amyloid Deposition – A Cytological Diagnosis
Archives of Medicine and Health SciencesPlasmacytoma with amyloid deposition to be diagnosed on cytology is rare. In the absence of typical clinical presentation and radiological findings, the diagnosis of plasmacytoma may not be suspected.
Durre Aden +3 more
doaj +1 more source
The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
Nature Reviews Neuroscience, 2021 G. Frisoni +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression [PDF]
, 2008 Catherine R. Burton +31 more
openalex +1 more source
The expanding amyloid family: Structure, stability, function, and pathogenesis [PDF]
, 2021 M.R. Sawaya +4 more
openalex +1 more source
Integration of Genetic and Imaging Data for Alzheimer's Disease Diagnosis and Interpretation
Advanced Science, EarlyView.AlzCLIP is a novel contrastive learning framework that integrates single nucleotide polymorphism (SNP) profiles and MRI‐derived imaging features into a unified representation space to improve Alzheimer's disease (AD) diagnosis and interpretation. By achieving superior diagnostic accuracy and revealing key genetic and structural contributors to AD risk,
Yanfei Wang +7 more
wiley +1 more source
Structure of amyloid β25–35 in lipid environment and cholesterol-dependent membrane pore formation [PDF]
, 2019 Nabin Kandel +2 more
openalex +1 more source