Results 11 to 20 of about 646,127 (297)
Interaction of Proteins Involved in Neuronal Proteinopathies
Life, 2023 Proteinopathy is characterized by the accumulation of aggregates of a specific protein in a target organ, tissue, or cell. The aggregation of the same protein can cause different pathologies as single protein can adopt various amyloidogenic, disease ...
Konstantin Y. Kulichikhin +4 more
doaj +1 more source
Applied Biochemistry and Biotechnology, 2012 The common view of amyloids and prion proteins is that they are associated with many currently incurable diseases and present a great danger to an organism. This danger comes from the fact that not only prion proteins, but also the infectious form(s) of amyloids, as it has been shown recently, are able to transmit the disease.
Pulawski W +3 more
openaire +2 more sources
Functional Mammalian Amyloids and Amyloid-Like Proteins
Life, 2020 Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD ...
Maria S. Rubel +6 more
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General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]
, 2014 Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Raleigh, David, Wang, Hui
core +4 more sources
eJHaem, 2022 The causal protein of amyloid light‐chain (AL) amyloidosis is a monoclonal immunoglobulin free light chain (mFLC), which must be quantified in the serum for patient diagnosis and monitoring.
Hajer Abroud +18 more
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Current Opinion in Neurology, 2012 As amyloid neuropathies have benefited from recent major progress, this review is timely and relevant.The main recent articles on amyloid neuropathy cover its description, methods for diagnosis and therapies. Varied clinical presentations are described in transthyretin (TTR)-familial amyloidosis with polyneuropathy (FAP) and light chain amyloid ...
David, Adams +2 more
openaire +4 more sources
Amyloid imaging in aging and dementia: testing the amyloid hypothesis in vivo. [PDF]
, 2009 Amyloid imaging represents a major advance in neuroscience, enabling the detection and quantification of pathologic protein aggregations in the brain. In this review we survey current amyloid imaging techniques, focusing on positron emission tomography ...
Jagust, WJ, Rabinovici, GD
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Cerebral Amyloid and Hypertension are Independently Associated with White Matter Lesions in Elderly. [PDF]
, 2015 In cognitively normal (CN) elderly individuals, white matter hyperintensities (WMH) are commonly viewed as a marker of cerebral small vessel disease (SVD).
Alzheimer’s Disease Neuroimaging Initiative +7 more
core +2 more sources
Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]
, 2015 Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris +7 more
core +1 more source
The relationship between amyloid structure and cytotoxicity [PDF]
, 2014 Self-assembly of proteins and peptides into amyloid structures has been the subject of intense and focused research due to their association with neurodegenerative, age-related human diseases and transmissible prion diseases in humans and mammals. Of the
Marchante, Ricardo +3 more
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