Results 11 to 20 of about 514,761 (295)
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer’s disease
Nature, 2023 Mouse models show that myelin dysfunction and associated inflammation increase with age, which can promote amyloid-β deposition and therefore risk of developing Alzheimer’s disease. The incidence of Alzheimer’s disease (AD), the leading cause of dementia,
Constanze Depp +29 more
semanticscholar +1 more source
The Amyloid-β Pathway in Alzheimer’s Disease
Molecular Psychiatry, 2021 Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer’s disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics leading to synaptic failure,
H. Hampel +14 more
semanticscholar +1 more source
The amyloid hypothesis of Alzheimer's disease at 25 years
EMBO Molecular Medicine, 2016 Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of evidence from laboratories and clinics worldwide support the concept that an imbalance between production and clearance of Aβ42 and related Aβ peptides is a very early,
D. Selkoe, J. Hardy
semanticscholar +1 more source
Amyloid: Journal of Protein Folding Disorders, 2022 The Nomenclature Committee of the International Society of Amyloidosis met at the XVIII International Symposium on Amyloidosis in September and virtually in October 2022 with discussions resulting in this upgraded nomenclature recommendation.
J. Buxbaum +7 more
semanticscholar +1 more source
An Efficient Method for Isolation of Plasmid DNA for Transfection of Mammalian Cell Cultures
Methods and Protocols, 2020 In this article, we present several protocols that describe the steps from cloning and obtaining a large amount of pure plasmid DNA to generation of lentiviruses based on these constructs.
Daniel V. Kachkin +3 more
doaj +1 more source
Prevalence and determinants of iron deficiency in cardiac amyloidosis
ESC Heart Failure, 2022 Aims Iron deficiency (ID) is common in patient with chronic heart failure (HF) and has been widely studied. In contrast, data concerning ID in cardiac amyloidosis (CA) are limited.
Antoine Jobbé‐Duval +19 more
doaj +1 more source
Synthetic prions generated in vitro are similar to a newly identified subpopulation of PrPSc from sporadic Creutzfeldt-Jakob disease [PDF]
, 2005 In recent studies, the amyloid form of recombinant prion protein (PrP) encompassing residues 89–230 (rPrP 89-230) produced in vitro induced transmissible prion disease in mice.
Adler +66 more
core +2 more sources
Experimental Hematology & Oncology, 2018 Background The monoclonal antibody daratumumab, approved for treating myeloma, targets CD38, a protein on myeloma and also on CD34+ hematopoietic progenitor cells.
Xun Ma +13 more
doaj +1 more source
BMC Nephrology, 2022 Background Multiple myeloma (MM) is a malignant neoplasm associated with kidney involvement in nearly half of the patients. Cast nephropathy, monoclonal immunoglobulin deposition disease (MIDD), and light chain (AL) amyloidosis are the most common ...
Samantha Innocenti +9 more
doaj +1 more source
Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease
Brain : a journal of neurology, 2021 Although recent clinical trials targeting amyloid-β in Alzheimer’s disease have shown promising results, there is increasing evidence suggesting that understanding alternative disease pathways that interact with amyloid-β metabolism and amyloid pathology
J. Pereira +10 more
semanticscholar +1 more source