Results 61 to 70 of about 516,976 (376)

Brain amyloid and the transition to dementia in Down syndrome

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Down syndrome (DS) is associated with elevated risk for Alzheimer's disease (AD) due to amyloid beta (Aβ) lifelong accumulation. We hypothesized that the spatial distribution of brain Aβ predicts future dementia conversion in individuals ...
David B. Keator, Eric Doran, Lisa Taylor, Michael J. Phelan, Christy Hom, Katherine Tseung, Theo G. M. vanErp, Steven G. Potkin, Adam M. Brickman, Diana H. Rosas, Michael A. Yassa, Wayne Silverman, Ira T. Lott   +12 more
doaj   +1 more source

Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity. [PDF]

, 2012
The amyloid protein aggregation associated with diseases such as Alzheimer's, Parkinson's and type II diabetes (among many others) features a bewildering variety of β-sheet-rich structures in transition from native proteins to ordered oligomers and ...
Cheng, Pin-Nan, Eisenberg, David, Liu, Cong, Nowick, James S, Zhao, Minglei   +4 more
core  

Neuroanatomical spread of amyloid β and tau in Alzheimer's disease: implications for primary prevention. [PDF]

, 2020
With recent advances in our understanding of the continuous pathophysiological changes that begin many years prior to symptom onset, it is now apparent that Alzheimer's disease cannot be adequately described by discrete clinical stages, but should also ...
Aisen, Paul S, Donohue, Michael C, Insel, Philip S, Mormino, Elizabeth C, Thompson, Wesley K   +4 more
core   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source

Analysis of the Amyloid-like Properties of COL2A1 Protein

Proceedings
Amyloids are proteins which exist in the form of insoluble aggregates and possess a characteristic cross-beta structure [...]
Aleksandra Brukkel, Andrew A. Zelinsky, Marina V. Ryabinina, Aleksandr A. Rubel   +3 more
doaj   +1 more source

Prediction of rapid amyloid and phosphorylated‐Tau accumulation in cognitively healthy individuals

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Objective To test the hypothesis that among cognitively healthy individuals, distinct groups exist in terms of amyloid and phosphorylated‐tau accumulation rates; that if rapid accumulator groups exist, their membership can be predicted by Alzheimer's ...
Ivan Koychev, Nemanja Vaci, Murat Bilgel, Yang An, Graciela Terrera Muniz, Dean F. Wong, John Gallacher, Abhay Mogekhar, Marilyn Albert, Susan M. Resnick   +9 more
doaj   +1 more source

Analyzing the Spatiotemporal Interaction and Propagation of ATN Biomarkers in Alzheimer's Disease using Longitudinal Neuroimaging Data [PDF]

arXiv, 2021
Three major biomarkers: beta-amyloid (A), pathologic tau (T), and neurodegeneration (N), are recognized as valid proxies for neuropathologic changes of Alzheimer's disease. While there are extensive studies on cerebrospinal fluids biomarkers (amyloid, tau), the spatial propagation pattern across brain is missing and their interactive mechanisms with ...
arxiv  

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers [PDF]

, 2019
Desmin-associated myofibrillar myopathy (MFM) has pathologic similarities to neurodegeneration-associated protein aggregate diseases. Desmin is an abundant muscle-specific intermediate filament, and disease mutations lead to its aggregation in cells ...
Arhzaouy, Khalid, Batchelor, Mark, Bieschke, Jan, Kedia, Niraja, Pittman, Sara K., Sun, Yuanzi, Weihl, Conrad C.   +6 more
core   +1 more source

Natural history and outcome in systemic AA amyloidosis [PDF]

, 2007
BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Gallimore, JR, Gilbertson, JA, Gillmore, JD, Goodman, HJB, Hawkins, PN, Lachmann, HJ, Sabin, CA   +6 more
core   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source