Results 91 to 100 of about 1,185,249 (285)
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Intracellular pH regulates amyloid precursor protein intracellular domain accumulation
Neurobiology of Disease, 2007 The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux +8 more
doaj +1 more source
β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]
, 2004 β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y. +2 more
core
Characterization of amyloid-ß and other proteins related to Alzheimer's disease, their role in neurodegeneration and biomarker discovery [PDF]
, 2006 Studies were performed to identify factors explaining the difference in the neurodegeneration seen in Alzheimer’s disease (AD) and in transgenic mice.
Güntert, Andreas
core +1 more source
Advanced Science, EarlyView.This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song +5 more
wiley +1 more source
Effects of methylglyoxal on amyloid‐beta peptide
The FASEB Journal, 2008 Diabetics exhibit elevated levels of carbohydrates and their oxidized byproducts such as methylglyoxal (MGO). With the excess production and accumulation of the amyloid‐beta peptide (ABP) in AD, the linkage between diabetes and AD may involve ABP and MGO. We studied the effects of MGO‐induced ABP modification on conformational properties. Human isoform
Randal Cerf Michelson, Norbert W Seidler
openaire +1 more source
The interaction of amyloid-β peptide with lipid membranes and glycosaminoglycans [PDF]
, 2012 The aim of the thesis is a better understanding of the thermodynamics and structural aspects of the interaction of Aβ(1-40) with lipid membranes and glycosaminoglycans (GAGs).
Müller, Christian Thomas Benedikt
core +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Progress on the correlation between exosomal microRNAs and Alzheimer's disease [PDF]
Jichu yixue yu linchuang, 2020 Alzheimer's disease is the most common dementia in the aged population and is characterizd by hidden attack and progressive development. Some studies showed that exosomal microRNAs(miRNAs) regulates the shearing of amyloid precusor protein,deposition of ...
DIAO Hua-qiong, LI Xiao-li, LIN Liang-yin, LIU Hai-peng, CHEN Hong-jing, DING Hai-yue, WEI Dan
doaj
Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly [PDF]
, 2008 Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid results in numerous human diseases. Despite an increasing number of proteins and peptide fragments being recognised as amyloidogenic, how these amyloid aggregates ...
Xue, Wei-Feng +2 more
core +1 more source