Results 71 to 80 of about 76,126 (160)

Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

Neuropsychiatric Disease and Treatment, 2015
Zhiyou Cai,1 Yingjun Zhou,1 Zhou Liu,2,3 Zunyu Ke,1 Bin Zhao2,3 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 2Department of Neurology, The Affiliated Hospital of Guangdong Medical College, 3Institute ...
Cai Z, Zhou Y, Liu Z, Ke Z, Zhao B
doaj  

Insights into proton transfer dynamics in histidine tautomers of amyloid-β (1-40)

Communications Chemistry
Histidine tautomerization within amyloid beta (Aβ) peptides is crucial in understanding the molecular mechanisms underlying Alzheimer’s disease and its potential therapeutic strategies.
Yingqi Tang, Yoshifumi Nishimura, Nannan Li, Hai Li, Abbas Salimi, Kensuke Ishida, Aditya Wibawa Sakti, Hiromi Nakai, Rakesh Parida, Jin Yong Lee   +9 more
doaj   +1 more source

Pilot Study: Lymphatic Brain Decongestion: A New Surgical Technique in Alzheimer Disease

Plastic and Reconstructive Surgery, Global Open
Background:. Alzheimer disease (AD) is characterized by progressive cognitive function decline and neurodegeneration. Accumulation of amyloid-beta peptides forms plaques leading to brain inflammation and neuronal death. Glymphatic and meningeal lymphatic
Anastasios Topalis, MD, Chrysanthi Bekiari, PhD, Efterpi Demiri, MD, PhD, Dimitrios Dionyssiou, MD, PhD   +3 more
doaj   +1 more source

Amyloid Beta Peptides and Th1 Cytokines Modulate Human Brain Vascular Smooth Muscle Tonic Contractile Capacity In Vitro: Relevance to Alzheimer's Disease? [PDF]

Pathophysiology, 2021
Yun JW, Washington C, McCormick J, Stevenson E, Alexander JS.   +4 more
europepmc   +1 more source

Amyloid-Beta Peptides and Activated Astroglia Impairs Proliferation of Nerve Growth Factor Releasing Cells In Vitro: Implication for Encapsulated Cell Biodelivery-Mediated AD Therapy. [PDF]

Cells, 2021
Mitra S, Turchetto S, Van Os W, Wahlberg LU, Linderoth B, Behbahani H, Eriksdotter M.   +6 more
europepmc   +1 more source

Knock-Down of HDAC2 in Human Induced Pluripotent Stem Cell Derived Neurons Improves Neuronal Mitochondrial Dynamics, Neuronal Maturation and Reduces Amyloid Beta Peptides. [PDF]

Int J Mol Sci, 2021
Frankowski H, Yeboah F, Berry BJ, Kinoshita C, Lee M, Evitts K, Davis J, Kinoshita Y, Morrison RS, Young JE.   +9 more
europepmc   +1 more source

Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer's disease. [PDF]

Brain Commun
Llorente-Saguer I, Gabriele R, Bradshaw TY, Leckey CA, Belder CRS, Chávez-Gutiérrez L, de Silva R, Fox NC, Wray S, Oxtoby NP, Arber C.   +10 more
europepmc   +1 more source

Microglia Do Not Take Up Soluble Amyloid-beta Peptides, But Partially Degrade Them by Secreting Insulin-degrading Enzyme. [PDF]

Neuroscience, 2020
Fu H, Liu B, Li L, Lemere CA.
europepmc   +1 more source

Analytical and Clinical Performance of Amyloid-Beta Peptides Measurements in CSF of ADNIGO/2 Participants by an LC-MS/MS Reference Method. [PDF]

Clin Chem, 2020
Korecka M, Figurski MJ, Landau SM, Brylska M, Alexander J, Blennow K, Zetterberg H, Jagust WJ, Trojanowski JQ, Shaw LM, Alzheimer’s Disease Neuroimaging Initiative.   +10 more
europepmc   +1 more source

Amyloid beta peptides inhibit glucose transport at the blood-brain barrier by disrupting the insulin-AKT pathway. [PDF]

J Cereb Blood Flow Metab
Wang L, Curran GL, Zhong R, Xue Z, Veerareddy V, Thieschafer J, Min PH, Li L, Lowe VJ, Kandimalla KK.   +9 more
europepmc   +1 more source