Results 51 to 60 of about 76,126 (160)

The role of astrocytes in Alzheimer's disease, A systematic review

Journal of Current Oncology and Medical Sciences, 2023
Introduction: Alzheimer's disease (AD), the most common neurodegenerative disease in the world, appears in two forms, early and late. Pathologically, an amyloid beta peptide is the hallmark of this disease which is followed by synaptic dysfunction, brain
Seyyed Mohammad Taghi Razavi-Toosi, Parvin Babaei, Arefeh Salehi   +2 more
doaj  

Amyloid Beta Peptide Is Released during Thrombosis in the Skin [PDF]

International Journal of Molecular Sciences, 2018
While it is known that amyloid beta (Aβ) deposits are found in different tissues of both Alzheimer’s disease (AD) patients and healthy individuals, there remain questions about the physiological role of these deposits, the origin of the Aβ peptide, and the mechanisms of its localization to the tissues.
Lilia Y. Kucheryavykh, Yuriy V. Kucheryavykh, A. Valance Washington, Mikhail Y. Inyushin   +3 more
openaire   +2 more sources

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits

Nature Communications, 2019
The potential links between infections and neurodegenerative disorders are unclear. Here, Wu et al. present a mouse model of low-grade candidemia characterized by highly localized cerebritis, accumulation of amyloid precursor protein and beta peptides ...
Yifan Wu, Shuqi Du, Jennifer L. Johnson, Hui-Ying Tung, Cameron T. Landers, Yuwei Liu, Brittany G. Seman, Robert T. Wheeler, Mauro Costa-Mattioli, Farrah Kheradmand, Hui Zheng, David B. Corry   +11 more
doaj   +1 more source

A guide to selecting high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence [version 2; peer review: 2 approved, 1 approved with reservations]

F1000Research
The amyloid-beta precursor protein is a transmembrane protein expressed in many tissues and highly concentrated in the brain. The protein is of significant interest due to its involvement in the generation of amyloidogenic β-amyloid peptides, prone to ...
Carl Laflamme, Kathleen Southern, Donovan Worrall, Riham Ayoubi, Maryam Fotouhi   +4 more
doaj   +1 more source

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) metabolism is central to pathogenesis of Alzheimer’s disease (AD). Parenchymal amyloid deposits, a neuropathological hallmark of AD, are composed of amyloid-beta peptides (Abeta).
Valérie Vingtdeux, Malika Hamdane, Séverine Bégard, Anne Loyens, André Delacourte, Jean-Claude Beauvillain, Luc Buée, Philippe Marambaud, Nicolas Sergeant   +8 more
doaj   +1 more source

Effects of methylglyoxal on amyloid‐beta peptide

The FASEB Journal, 2008
Diabetics exhibit elevated levels of carbohydrates and their oxidized byproducts such as methylglyoxal (MGO). With the excess production and accumulation of the amyloid‐beta peptide (ABP) in AD, the linkage between diabetes and AD may involve ABP and MGO. We studied the effects of MGO‐induced ABP modification on conformational properties. Human isoform
Randal Cerf Michelson, Norbert W Seidler
openaire   +1 more source

Progress on the correlation between exosomal microRNAs and Alzheimer's disease [PDF]

Jichu yixue yu linchuang, 2020
Alzheimer's disease is the most common dementia in the aged population and is characterizd by hidden attack and progressive development. Some studies showed that exosomal microRNAs(miRNAs) regulates the shearing of amyloid precusor protein,deposition of ...
DIAO Hua-qiong, LI Xiao-li, LIN Liang-yin, LIU Hai-peng, CHEN Hong-jing, DING Hai-yue, WEI Dan
doaj  

Corrigendum to "Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency". [PDF]

Mol Genet Metab Rep, 2023
Rahhal S, Farmer C, Thurm A, Wassif CA, Cawley NX, Perreault J, Dang Do A, Bianconi S, Hannah-Shmouni F, Guthrie W, Cubit LS, Miller JS, Sutton VR, Koeberl D, Porter FD.   +14 more
europepmc   +1 more source

Microglial Phagocytosis Assay

Bio-Protocol, 2016
Phagocytosis is essential for microglial clearance of apoptotic cells, extracellular protein aggregates, and infectious bacteria in the central nervous system (CNS).
Hong Lian, Ethan Roy, Hui Zheng
doaj   +1 more source

Human cystatin C induces the disaggregation process of selected amyloid beta peptides: a structural and kinetic view. [PDF]

Sci Rep, 2023
Żyła A, Martel A, Jurczak P, Moliński A, Szymańska A, Kozak M.   +5 more
europepmc   +1 more source