Investigation of low amyloid level toxicity effects on the function of hippocampal neurons
Open Life Sciences, 2015 Alzheimer disease (AD) is responsible for the majority of elderly dementia cases. There are multiple mouse models of AD, however, none of them completely recapitulate human pathology.
Popugaeva Elena +4 more
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Biomolecular studies in Alzheimer’s Disease models: investigations in vitro and in vivo
, 2013 The Alzheimer’s disease (AD), the most prevalent form of age-related dementia, is a multifactorial and heterogeneous neurodegenerative disease. The molecular mechanisms underlying the pathogenesis of AD are yet largely unknown.
Lattanzio, Francesca <1982>
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Characterization of amyloid-ß and other proteins related to Alzheimer's disease, their role in neurodegeneration and biomarker discovery [PDF]
, 2006 Studies were performed to identify factors explaining the difference in the neurodegeneration seen in Alzheimer’s disease (AD) and in transgenic mice.
Güntert, Andreas
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Estudo bioquímico e comportamental em camundongos submetidos à infusão intracerebroventricular dos peptídeos beta-amilóide AB1-40 E AB25-35 e o papel neuroprotetor da atorvastatina [PDF]
, 2009 Dissertação (mestrado) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.The accumulation and aggregation of beta-amyloid peptide (Aâ) in brain of patients with Alzheimer's disease results
Piermartiri, Tetsade Camboim Bizerra
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Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH.
, 2002 BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen +5 more
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Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly [PDF]
, 2008 Self-assembly of misfolded proteins into ordered fibrillar aggregates known as amyloid results in numerous human diseases. Despite an increasing number of proteins and peptide fragments being recognised as amyloidogenic, how these amyloid aggregates ...
Xue, Wei-Feng +2 more
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Advanced Functional Materials, EarlyView.We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins +9 more
wiley +1 more source
Oxidative stress and the amyloid beta peptide in Alzheimer’s disease
Redox Biology, 2018 Oxidative stress is known to play an important role in the pathogenesis of a number of diseases. In particular, it is linked to the etiology of Alzheimer's disease (AD), an age-related neurodegenerative disease and the most common cause of dementia in the elderly.
Cheignon, Clémence +5 more
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Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells
Anais da Academia Brasileira de Ciências, 2014 Protein tau plays a pivotal role in the pathophysiology of Alzheimer's disease, where its hyperphos-phorylation promotes aggregation and microtubule destabilization.
TERESA LAGUNES +3 more
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The interaction of amyloid-β peptide with lipid membranes and glycosaminoglycans [PDF]
, 2012 The aim of the thesis is a better understanding of the thermodynamics and structural aspects of the interaction of Aβ(1-40) with lipid membranes and glycosaminoglycans (GAGs).
Müller, Christian Thomas Benedikt
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