Results 31 to 40 of about 76,126 (160)
Brazilian Journal of Biology, 2021 Resveratrol, a natural polyphenol found in tempeh, has not been investigated especially in vitro as a neuroprotective agent against 2-methoxyethanol (2-ME)-induced beta-amyloid cytotoxicity. Beta amyloid peptides (Aβ) could initiate neurotoxic events and
Y. Irnidayanti +4 more
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Amyloid-.BETA. peptide metabolism and Alzheimer's disease
Folia Pharmacologica Japonica, 2003 The deposition of amyloid-beta peptide (Abeta) causes the long-term pathological cascade of Alzheimer's disease (AD). Neprilysin is a rate-limiting peptidase, which participates in Abeta degradation in brain. As demonstrated by reverse genetics, the disruption of neprilysin gene causes an elevation in endogenous Abeta levels in the mouse brain in a ...
IWATA, Nobuhisa, SAIDO, Takaomi C.
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International Journal of Electrochemical Science, 2019 Beta-amyloid (Aβ) peptides are the specific biomarkers of Alzheimer's disease (AD). Many clinical studies have suggested that abnormal levels of Aβ peptides in blood, cerebrospinal fluid and brain tissue are closely related to the progression of AD ...
Ming La +4 more
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Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
Life, 2023 Senile plaques consisting of amyloid-beta (Aβ) peptides are a major pathological hallmark of Alzheimer’s disease (AD). Aβ peptides are heterogeneous regarding the exact length of their amino- and carboxy-termini. Aβ1-40 and Aβ1-42 are often considered to
Angelika Sabine Bader +9 more
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Effects of Amyloid Beta Peptide on Neurovascular Cells
Central Asian Journal of Global Health, 2013 Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the neurons, and progressive deterioration of cognition and memory of affected individuals.
Sholpan Askarova +3 more
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Oligomers mediate the spatial transmission of Aβ peptide aggregation
Communications ChemistryAlzheimer’s disease (AD) is marked by the abnormal aggregation of amyloid-beta peptides within the central nervous system. The formation of amyloid fibrils from amyloid-beta peptides is a hallmark of AD Here, we demonstrate that the aggregation of ...
Quentin Peter +7 more
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Molecules, 2020 Alzheimer’s disease (AD) is the most common form of dementia, characterized by chronic neuron loss and cognitive problems. Aggregated amyloid beta (Aβ) peptides, a product of cleaved amyloid precursor protein (APP) by beta-secretase 1 (BACE-1), have been
Uthaiwan Suttisansanee +5 more
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Frontiers in Molecular Neuroscience, 2023 Recent studies promote new interest in the intersectionality between autism spectrum disorder (ASD) and Alzheimer’s Disease. We have reported high levels of Amyloid-β Precursor Protein (APP) and secreted APP-alpha (sAPPa) and low levels of amyloid-beta ...
Deborah K. Sokol +2 more
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Investigation of low amyloid level toxicity effects on the function of hippocampal neurons
Open Life Sciences, 2015 Alzheimer disease (AD) is responsible for the majority of elderly dementia cases. There are multiple mouse models of AD, however, none of them completely recapitulate human pathology.
Popugaeva Elena +4 more
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Abeta(1-42) induces abnormal alternative splicing of tau exons 2/3 in NGF-induced PC12 cells
Anais da Academia Brasileira de Ciências, 2014 Protein tau plays a pivotal role in the pathophysiology of Alzheimer's disease, where its hyperphos-phorylation promotes aggregation and microtubule destabilization.
TERESA LAGUNES +3 more
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