Results 31 to 40 of about 109,107 (305)

Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]

, 2006
Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core   +1 more source

G82S RAGE polymorphism is associated with Alzheimer’s disease

Frontiers in Bioscience-Elite, 2020
Receptor for advanced glycation end products (RAGE) has been implicated in the pathophysiology of Alzheimer’s disease (AD) due to its ability to interact with amyloid beta and to elicit an inflammatory response. sRAGE, one of the splice variants of RAGE,
Rani Cathrine Chellappa, Palaniswamy Rani   +1 more
doaj   +1 more source

Autoxidation Enhances Anti-Amyloid Potential of Flavone Derivatives

Antioxidants, 2021
The increasing prevalence of amyloid-related disorders, such as Alzheimer’s or Parkinson’s disease, raises the need for effective anti-amyloid drugs. It has been shown on numerous occasions that flavones, a group of naturally occurring anti-oxidants, can
Andrius Sakalauskas, Mantas Ziaunys, Ruta Snieckute, Vytautas Smirnovas   +3 more
doaj   +1 more source

Fibril fragmentation in amyloid assembly and cytotoxicity: When size matters [PDF]

, 2010
Amyloid assemblies are associated with several debilitating human disorders. Understanding the intra- and extracellular assembly of normally soluble proteins and peptides into amyloid aggregates and how they disrupt normal cellular functions is therefore
Xue, Wei-Feng, Hellewell, Andrew L., Hewitt, Eric W., Radford, Sheena E.   +3 more
core   +1 more source

Advances in the pathogenesis of Alzheimer’s disease: a re-evaluation of amyloid cascade hypothesis

Translational Neurodegeneration, 2012
Alzheimer’s disease (AD) is a common neurodegenerative disease characterized clinically by progressive deterioration of memory, and pathologically by histopathological changes including extracellular deposits of amyloid-beta (A-beta) peptides forming ...
Dong Suzhen, Duan Yale, Hu Yinghe, Zhao Zheng   +3 more
doaj   +1 more source

Curcumin Inhibits the Primary Nucleation of Amyloid-Beta Peptide: A Molecular Dynamics Study

Biomolecules, 2020
The amyloid plaques are a key hallmark of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Amyloidogenesis is a complex long-lasting multiphase process starting with the formation of nuclei of amyloid peptides: a process ...
Irini Doytchinova, Mariyana Atanasova, Evdokiya Salamanova, Stefan Ivanov, Ivan Dimitrov   +4 more
doaj   +1 more source

Intracellular accumulation of amyloid-beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease

Frontiers in Aging Neuroscience, 2010
Despite of long-standing evidence that beta-amyloid (Aβ) peptides have detrimental effects on synaptic function, the relationship between Aβ, synaptic and neuron loss is largely unclear.
Thomas A Bayer
doaj   +1 more source

Potential neuroprotective of trans-resveratrol a promising agent tempeh and soybean seed coats-derived against beta-amyloid neurotoxicity on primary culture of nerve cells induced by 2-methoxyethanol

Brazilian Journal of Biology, 2021
Resveratrol, a natural polyphenol found in tempeh, has not been investigated especially in vitro as a neuroprotective agent against 2-methoxyethanol (2-ME)-induced beta-amyloid cytotoxicity. Beta amyloid peptides (Aβ) could initiate neurotoxic events and
Y. Irnidayanti, D. R. Sutiono, N. Ibrahim, P. H. Wisnuwardhani, A. Santoso   +4 more
doaj   +1 more source

Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives [PDF]

Scientific Reports, 2017
AbstractThe self-assembly of two derivatives of KLVFF, a fragment Aβ(16–20) of the amyloid beta (Aβ) peptide, is investigated and recovery of viability of neuroblastoma cells exposed to Aβ (1–42) is observed at sub-stoichiometric peptide concentrations.
Castelletto, V., Ryumin, P., Cramer, R., Hamley, I. W., Taylor, M., Allsop, D., Reza, M., Ruokolainen, J., Arnold, T., Hermida-Merino, D., Garcia, C. I., Leal, M. C., Castaño, E.   +13 more
openaire   +8 more sources

Adsorption of Amyloid Beta Peptide by Metal–Organic Frameworks [PDF]

ACS Omega, 2020
Metal-organic frameworks (MOFs) are capable of adsorbing a wide range of molecules. In addition to the more commonly investigated small molecules, researchers have demonstrated that MOFs adsorb much larger molecules, such as proteins and peptides. We have investigated whether MOFs are capable of adsorbing amyloid beta peptide.
Zachary L. Mensinger, Brenna L. Cook, Elsie L. Wilson   +2 more
openaire   +3 more sources