Results 11 to 20 of about 109,107 (305)

Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease [PDF]

Biochemistry Research International, 2011
Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (A𝛽-)peptides in the brain causing progressive neuronal death.
Mallory Gough, Catherine Parr-Sturgess, Edward Parkin   +2 more
doaj   +2 more sources

Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex

Neuropsychiatric Disease and Treatment, 2015
Zhiyou Cai,1 Yingjun Zhou,1 Zhou Liu,2,3 Zunyu Ke,1 Bin Zhao2,3 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 2Department of Neurology, The Affiliated Hospital of Guangdong Medical College, 3Institute ...
Cai Z, Zhou Y, Liu Z, Ke Z, Zhao B
doaj   +1 more source

Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]

PLoS ONE, 2016
Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal, Georges Belfort, David Isaacson   +2 more
doaj   +1 more source

Ammonium Sulfate and Ultrafine Particles Affect Early Onset of Alzheimer’s Disease

Chemical Engineering Transactions, 2021
Recent environmental studies have shown the impact of air quality on human health and in particular, toxicological effect of particulate matter (PM) and ultrafine particles (UFPs) on progression of neurodegenerative diseases.
Samal Kaumbekova, Mehdi Amouei Torkmahalleh, Dhawal Shah   +2 more
doaj   +1 more source

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients

Frontiers in Aging Neuroscience, 2020
Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel, Diana Trujillo-Rodriguez, Andres Villegas, Johannes Streffer, Marc Mercken, Francisco Lopera, Markus Glatzel, Diego Sepulveda-Falla   +7 more
doaj   +1 more source

Astrocytic Redox Remodeling by Amyloid Beta Peptide [PDF]

Antioxidants & Redox Signaling, 2011
Astrocytes are critical for neuronal redox homeostasis providing them with cysteine needed for glutathione synthesis. In this study, we demonstrate that the astrocytic redox response signature provoked by amyloid beta (Aβ) is distinct from that of a general oxidant (tertiary-butylhydroperoxide [t-BuOOH]).
Garg, Sanjay K., Vitvitsky, Victor M., Albin, Roger L., Banerjee, Ruma   +3 more
openaire   +3 more sources

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

, 2009
Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Nakano, Yuko, Willem, Michael, Kudo, Takashi, Minagawa, Kazuyuki, Jiang, Jingwei, Okochi, Masayasu, Takemoto, Hiroshi, Hosono, Motoko, Nishimura, Masaki, Takeda, Masatoshi, Itoh, Naohiro, Nishigaki, Atsuko, Hasegawa, Hiroshi, Sakaguchi, Gaku, Kato, Akira, Haass, Christian, Tanaka, Toshihisa, Yanagida, Kanta, Mori, Kohji, Nakayama, Taisuke, Kikuchi, Jyunko, Dohi, Keiji, Takinami, Yoshihiko, Katoh, Takaaki, Nishitomi, Kouhei, Morihara, Takashi, Tagami, Shinji, Fukumori, Akio   +27 more
core   +1 more source

Casuarictin: A new herbal drug molecule for Alzheimer's disease as inhibitor of presenilin stabilization factor like protein

Heliyon, 2020
Alzheimer's disease is a progressive neurodegenerative disorder. In this disease neurodegeneration occurs due to deposition of aggregated amyloid-beta plaques and neurofibrillary tangles (hyperphosphorylated tau proteins).
Rupali Kumari, Amit Chaudhary, Ashutosh Mani   +2 more
doaj   +1 more source

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

Molecules, 2019
Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain
Raluca Ştefănescu, Gabriela Dumitriṭa Stanciu, Andrei Luca, Ioana Cezara Caba, Bogdan Ionel Tamba, Cosmin Teodor Mihai   +5 more
doaj   +1 more source

Insight into the structure of amyloid fibrils from the analysis of globular proteins. [PDF]

PLoS Computational Biology, 2006
The conversion from soluble states into cross-beta fibrillar aggregates is a property shared by many different proteins and peptides and was hence conjectured to be a generic feature of polypeptide chains.
Antonio Trovato, Fabrizio Chiti, Amos Maritan, Flavio Seno   +3 more
doaj   +1 more source